Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis

2017 ◽  
Vol 89 ◽  
pp. 1252-1261 ◽  
Author(s):  
Jian-Feng Xue ◽  
Zhong-Min Shi ◽  
Jian Zou ◽  
Xiao-Lin Li
Keyword(s):  
Inflammatory Response ◽  
Signaling Pathway ◽  
Articular Chondrocytes ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway

Atorvastatin ameliorates LPS‐induced inflammatory response by autophagy via AKT/mTOR signaling pathway

2017 ◽  
Vol 119 (2) ◽  
pp. 1604-1615 ◽  
Author(s):  
Fei Han ◽  
Qing‐Qing Xiao ◽  
Shi Peng ◽  
Xin‐Yu Che ◽  
Li‐Sheng Jiang ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Signaling Pathway ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway

scholarly journals The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

Immunity ◽  
2008 ◽  
Vol 29 (4) ◽  
pp. 565-577 ◽  
Author(s):  
Thomas Weichhart ◽  
Giuseppina Costantino ◽  
Marko Poglitsch ◽  
Margit Rosner ◽  
Maximilian Zeyda ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Signaling Pathway ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway

UPF1 Impacts on mTOR Signaling Pathway and Autophagy in Endometrioid Endometrial Carcinoma

2020 ◽  
Author(s):  
Minfen Zhang ◽  
Hui Chen ◽  
Ping Qin ◽  
Tonghui Cai ◽  
Lingjun Li ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway

Targeting mammalian target of rapamycin: prospects for the treatment of inflammatory bowel diseases

2020 ◽  
Vol 27 ◽  
Author(s):  
Naser-Aldin Lashgari ◽  
Nazanin Momeni Roudsari ◽  
Saeideh Momtaz ◽  
Negar Ghanaatian ◽  
Parichehr Kohansal ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Mammalian Target Of Rapamycin ◽  
Mtor Pathway ◽  
Mtor Signaling ◽  
Target Of Rapamycin ◽  
In Vivo Studies ◽  
Cochrane Library ◽  
Mtor Signaling Pathway ◽  
Inflammatory Bowel

: Inflammatory bowel disease (IBD) is a general term for a group of chronic and progressive disorders. Several cellular and biomolecular pathways are implicated in the pathogenesis of IBD, yet the etiology is unclear. Activation of the mammalian target of rapamycin (mTOR) pathway in the intestinal epithelial cells was also shown to induce inflammation. This review focuses on the inhibition of the mTOR signaling pathway and its potential application in treating IBD. We also provide an overview on plant-derived compounds that are beneficial for the IBD management through modulation of the mTOR pathway. Data were extracted from clinical, in vitro and in vivo studies published in English between 1995 and May 2019, which were collected from PubMed, Google Scholar, Scopus and Cochrane library databases. Results of various studies implied that inhibition of the mTOR signaling pathway downregulates the inflammatory processes and cytokines involved in IBD. In this context, a number of natural products might reverse the pathological features of the disease. Furthermore, mTOR provides a novel drug target for IBD. Comprehensive clinical studies are required to confirm the efficacy of mTOR inhibitors in treating IBD.

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