Antiproliferative activity of thiazole and oxazole derivatives: A systematic review of in vitro and in vivo studies

This systematic review evaluated the transplantation of cells derived from adipose tissue for applications in dentistry. SCOPUS, PUBMED and LILACS databases were searched for in vitro studies and pre-clinical animal model studies using the keywords “ADIPOSE”, “CELLS”, and “PERIODONTAL”, with the Boolean operator “AND”. A total of 160 titles and abstracts were identified, and 29 publications met the inclusion criteria, 14 in vitro and 15 in vivo studies. In vitro studies demonstrated that adipose- derived cells stimulate neovascularization, have osteogenic and odontogenic potential; besides adhesion, proliferation and differentiation on probable cell carriers. Preclinical studies described improvement of bone and periodontal healing with the association of adipose-derived cells and the carrier materials tested: Platelet Rich Plasma, Fibrin, Collagen and Synthetic polymer. There is evidence from the current in vitro and in vivo data indicating that adipose-derived cells may contribute to bone and periodontal regeneration. The small quantity of studies and the large variation on study designs, from animal models, cell sources and defect morphology, did not favor a meta-analysis. Additional studies need to be conducted to investigate the regeneration variability and the mechanisms of cell participation in the processes. An overview of animal models, cell sources, and scaffolds, as well as new perspectives are provided for future bone and periodontal regeneration study designs.

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Medicinal Plants with Anti-Trichomonas vaginalis Activity in Iran: A Systematic Review

Iranian Journal of Parasitology ◽

10.18502/ijpa.v14i1.712 ◽

2019 ◽

Cited By ~ 2

Author(s):

Hajar ZIAEI HEZARJARIBI ◽

Najmeh NADEALI ◽

Mahdi FAKHAR ◽

Masoud SOOSARAEI

Keyword(s):

Systematic Review ◽

Medicinal Plants ◽

Trichomonas Vaginalis ◽

Scientific Information ◽

Medicinal Herbs ◽

In Vivo Studies ◽

Eligibility Criteria ◽

Sexually Transmitted

Background: Trichomoniasis, due to Trichomonas vaginalis, is one of the most common sexually transmitted parasitic diseases in the world such as Iran. This systematic review aimed to explore the studies evaluating the medicinal herbs with anti- T. vaginalis activity which used in Iran. Methods: Articles published in 4 Persian and 4 English databases were obtained between 2000 and 2015 including Google Scholar, PubMed, Science Direct, Scopus, Magiran, Barakatkns (formerly IranMedex), Elm net, and SID (Scientific Information Database). Studies out of Iran, studies on animal models and articles on other parasite species than T. vaginalis were excluded from this review. Results: Twenty-one articles including in vitro experiments, met our eligibility criteria. Thoroughly, 26 types of plants were examined against T. vaginalis. Medicinal herbs such as Artemisia, Zataria multiflora, and Lavandula angustifolia are remarkably effective on T. vaginalis. As such, use of other parts of these plants in different concentrations and timelines is recommended for future in vivo studies. Conclusion: The present systematic review provides comprehensive and useful information about Iranian medicinal plants with anti-T. vaginalis activity, which would be examined in the future experimental and clinical trials and herbal combination therapy.

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Viscum album (L) extracts in cancer treatment: a systematic review of in vitro and in vivo studies

International Journal of High Dilution Research - ISSN 1982-6206 ◽

10.51910/ijhdr.v14i2.787 ◽

2021 ◽

Vol 14 (2) ◽

pp. 52-52

Author(s):

Aloisio Cunha de Carvalho ◽

Leoni Villano Bonamin

Keyword(s):

Systematic Review ◽

Experimental Studies ◽

Pharmaceutical Preparations ◽

Viscum Album ◽

In Vitro Models ◽

In Vivo Studies ◽

Pubmed Database ◽

Anti Cancer

Background: Several reviews about phytotherapy and homeopathy have been published in the last years, including Viscum album (VA.L). VA is a parasite plant whose extract has anti-cancer proprieties and is used alone or in combination with conventional chemotherapy. Methods: We performed a systematic review about the in vivo and in vitro models described in the literature, including veterinary clinical trials. The literature was consulted from Pubmed database. Results: There are several kinds of pharmaceutical preparations about VA and their active principles used in experimental studies, lectin being frequently studied (alone or as an extract compound). More than 50% of available literature about VA is related to the lectin effects. On the other hand, the effects of viscotoxins are less studied. Among the in vivo experimental studies about VA and its compounds, the B16 murine melanoma is the most used model, followed by Ehrlich, Walker and Dalton tumors. The results point to the apoptotic effects, metastasis control and tumor regression. Some veterinary clinical studies about the use of VA in the treatment of sarcoid, fibrosarcoma and neuroblastoma are quoted in literature too, with interesting results. Considering the in vitro models, our review revealed that NALM6 leukemia cells, B16 melanoma and NC1-H460 lung carcinoma were the most studied tumor models, apoptosis signals being the most important findings. Only one study verified immunoglobulin and interleukin production. All consulted papers were related to phytotherapy preparations only. Conclusions: Although the literature about the anti-cancer activity of VA extract and its lectins is enough, there is a marked lack of information about viscotoxin activities and about the effects of homeopathic preparations of this plant on animal tumors and on in vitro cultivated tumor cells.

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Hemoglobin E in Northeast India: A review on its origin, distribution, migration and health implication

Anthropological Review ◽

10.1515/anre-2016-0019 ◽

2016 ◽

Vol 79 (3) ◽

pp. 241-263 ◽

Cited By ~ 1

Author(s):

Mithun Sikdar

Keyword(s):

Systematic Review ◽

Northeast India ◽

Point Of View ◽

In Vivo Studies ◽

Mt Dna ◽

Hemoglobin E ◽

Health Implication ◽

Probable Origin

AbstractA systematic review of the studies on hemoglobin E in Northeast India has been carried out to understand the magnitude of research undertaken on this aspect during the last seven decades. Owing to the high prevalence of hemoglobin E in this part of India different authors have studied this hemoglobin from different perspectives and found conflicting results. However a systematic review of such studies is lacking from a holistic point of view. Most of the epidemiological, in vitro as well as in vivo studies show signatures of selection with this hemoglobin locus. However, how this polymorphism is maintained at different rates at different geographical region is still a matter of contention. This review will fill the gap from all perspectives starting from the frequency distribution of hemoglobin E and its spread in different parts of Northeast India, its relationship with malaria hypothesis, the population migration, population affinity and most importantly the health implication arising out of it. A probable origin of hemoglobin E among an Austroasiatic population of Northeast India has been postulated with the help of advance molecular anthropological knowledge like the deep rooted markers of mt DNA and Y-chromosome haplotypes.

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The pharmacology and clinical efficacy of matricaria recutita L.: a systematic review of in vitro, in vivo studies and clinical trials

Food Reviews International ◽

10.1080/87559129.2020.1834577 ◽

2020 ◽

pp. 1-35

Author(s):

Marta Sánchez ◽

Elena González-Burgos ◽

M. Pilar Gómez-Serranillos

Keyword(s):

Systematic Review ◽

Clinical Trials ◽

Clinical Efficacy ◽

In Vivo Studies ◽

Matricaria Recutita

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Anticancer prospects of earthworm extracts: A systematic review of In vitro and In vivo studies

Pharmacognosy Reviews ◽

10.4103/phrev.phrev_45_17 ◽

2018 ◽

Vol 12 (23) ◽

pp. 46 ◽

Cited By ~ 3

Author(s):

Dominic Augustine ◽

RoopaS Rao ◽

Jayaraman Anbu ◽

KN Chidambara Murthy

Keyword(s):

Systematic Review ◽

In Vivo Studies

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Biological properties of terpinolene evidenced by in silico, in vitro and in vivo studies: A systematic review

Phytomedicine ◽

10.1016/j.phymed.2021.153768 ◽

2021 ◽

Vol 93 ◽

pp. 153768

Author(s):

Isis Oliveira Menezes ◽

Jackelyne Roberta Scherf ◽

Anita Oliveira Brito Pereira Bezerra Martins ◽

Andreza Guedes Barbosa Ramos ◽

Jullyana de Souza Siqueira Quintans ◽

...

Keyword(s):

Systematic Review ◽

In Silico ◽

Biological Properties ◽

In Vivo Studies

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Anticarcinogenic and Antioxidant Action of an Edible Aquatic Flora Jussiaea repens L. Using In Vitro Bioassays and In Vivo Zebrafish Model

Molecules ◽

10.3390/molecules26082291 ◽

2021 ◽

Vol 26 (8) ◽

pp. 2291

Author(s):

Chongtham Rajiv ◽

Subhra Saikat Roy ◽

K. Tamreihao ◽

Pintubala Kshetri ◽

Thangjam Surchandra Singh ◽

...

Keyword(s):

Oxidative Stress ◽

Antiproliferative Activity ◽

Developmental Process ◽

In Vivo Studies ◽

Zebrafish Embryos ◽

Zebrafish Model ◽

Antioxidant Power ◽

Skov3 Cells

Oxidative stress is the major cause of many health conditions, and regular consumption of antioxidants helped to encounter and prevent such oxidative stress-related diseases. Due to safety concerns over long-term uses of synthetic antioxidants, natural antioxidants are more preferred. The purpose of this study is to investigate the antioxidant and anticancer activities of Jussiaea repens L., a wild edible flora found in Manipur, India. The antioxidant activity was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), Ferric reducing antioxidant power (FRAP) assay and DNA-nicking assay. The anticancer activity was tested using five cancer lines viz., SKOV3 cells (ovarian), HeLa (cervical), MDA-MB-231 (breast), PANC-1 (pancreatic), and PC3 (prostate). The toxicity, developmental effect, antiproliferative activity was further tested using zebrafish embryos. The methanolic plant extract had higher polyphenol content than flavonoids. The in vitro study demonstrated a promising antioxidant capacity and DNA protection ability of this plant. The extract also showed cytotoxic activity against SKOV3, HeLa, MDA-MB-23, and PANC-1 cancer cell lines. The in vivo studies on zebrafish embryos demonstrated the extract’s ability to suppress the developmental process and elicited more cytotoxicity to cancer cells than developing zebrafish embryos. Moreover, the in vivo studies on zebrafish embryos also indicated the antiproliferative activity of J. repens L. extract.

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Systematic Review of Diagnostic Sensors for Intra-Abdominal Pressure Monitoring

Sensors ◽

10.3390/s21144824 ◽

2021 ◽

Vol 21 (14) ◽

pp. 4824

Author(s):

Chien-Hung Liao ◽

Chi-Tung Cheng ◽

Chih-Chi Chen ◽

Yu-Hsin Wang ◽

Hsin-Tzu Chiu ◽

...

Keyword(s):

Systematic Review ◽

Abdominal Cavity ◽

Pressure Sensors ◽

In Vivo Studies ◽

Abdominal Pressure ◽

Wireless Sensing ◽

Sensing Systems ◽

Recent Developments

Intra-abdominal pressure (IAP) is defined as the steady-state pressure within the abdominal cavity. Elevated IAP has been implicated in many medical complications. This article reviews the current state-of-the-art in innovative sensors for the measurement of IAP. A systematic review was conducted on studies on the development and application of IAP sensors. Publications from 2010 to 2021 were identified by performing structured searches in databases, review articles, and major textbooks. Sixteen studies were eligible for the final systematic review. Of the 16 articles that describe the measurement of IAP, there were 5 in vitro studies (31.3%), 7 in vivo studies (43.7%), and 4 human trials (25.0%). In addition, with the advancement of wireless communication technology, an increasing number of wireless sensing systems have been developed. Among the studies in this review, five presented wireless sensing systems (31.3%) to monitor IAP. In this systematic review, we present recent developments in different types of intra-abdominal pressure sensors and discuss their inherent advantages due to their small size, remote monitoring, and multiplexing.

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The Revival of Aztreonam in Combination with Avibactam against Metallo-β-Lactamase-Producing Gram-Negatives: A Systematic Review of In Vitro Studies and Clinical Cases

Antibiotics ◽

10.3390/antibiotics10081012 ◽

2021 ◽

Vol 10 (8) ◽

pp. 1012

Author(s):

Carola Mauri ◽

Alberto Enrico Maraolo ◽

Stefano Di Bella ◽

Francesco Luzzaro ◽

Luigi Principe

Keyword(s):

Systematic Review ◽

Bloodstream Infections ◽

Mortality Rates ◽

In Vivo Studies ◽

High Antimicrobial Activity ◽

Lactam Antibiotic ◽

Vitro Data ◽

In Vitro Data

Infections caused by metallo-β-lactamase (MBL)-producing Enterobacterales and Pseudomonas are increasingly reported worldwide and are usually associated with high mortality rates (>30%). Neither standard therapy nor consensus for the management of these infections exist. Aztreonam, an old β-lactam antibiotic, is not hydrolyzed by MBLs. However, since many MBL-producing strains co-produce enzymes that could hydrolyze aztreonam (e.g., AmpC, ESBL), a robust β-lactamase inhibitor such as avibactam could be given as a partner drug. We performed a systematic review including 35 in vitro and 18 in vivo studies on the combination aztreonam + avibactam for infections sustained by MBL-producing Gram-negatives. In vitro data on 2209 Gram-negatives were available, showing the high antimicrobial activity of aztreonam (MIC ≤ 4 mg/L when combined with avibactam) in 80% of MBL-producing Enterobacterales, 85% of Stenotrophomonas and 6% of MBL-producing Pseudomonas. Clinical data were available for 94 patients: 83% of them had bloodstream infections. Clinical resolution within 30 days was reported in 80% of infected patients. Analyzing only patients with bloodstream infections (64 patients), death occurred in 19% of patients treated with aztreonam + ceftazidime/avibactam. The combination aztreonam + avibactam appears to be a promising option against MBL-producing bacteria (especially Enterobacterales, much less for Pseudomonas) while waiting for new antimicrobials.

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