Dysfunction of Preattentive Visual Information Processing Among Patients with Major Depressive Disorder

The adverse effects of depression on patients’ life have been reported but information about its effects on the sequential organization of the information processing stages remains poorly understood as previous studies focused only on distinct stages. This study adds to existing knowledge by examining the effect of major depressive disorder (MDD) on the sequential organization of information processing, executive and community functioning. Fifty-seven participants with 19 participants each for first episode depression (FMDD), recurrent episodes depression (RMDD), and healthy controls (HCs) participated in this study. They completed assessments on executive and community functioning measures, and choice reaction time task (CRTT) for the event-related potential (ERP) data. Findings revealed no significant between-group difference in executive functioning but participants with depression (FMDD and RMDD) were found to be more depressed, with FMDD participants having worse community functioning skills compared with HCs. There was no significant between-group main effect on behavioral data. ERP data showed significantly less positive-going P3b among RMDD participants compared with HCs. FMDD participants used a different information processing strategy at P1, while HCs and RMDD participants used a different processing strategy at N2b compared with the other group(s), respectively. The results suggest the use of multifaceted assessment to get a holistic view of the health status of people with MDD in order to inform clinicians on the appropriate interventional strategies needed for the patient.

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Cognitive and Neural Aspects of Information Processing in Major Depressive Disorder: An Integrative Perspective

Frontiers in Psychology ◽

10.3389/fpsyg.2012.00489 ◽

2012 ◽

Vol 3 ◽

Cited By ~ 59

Author(s):

Lara C. Foland-Ross ◽

Ian H. Gotlib

Keyword(s):

Major Depressive Disorder ◽

Information Processing ◽

Depressive Disorder ◽

Major Depressive

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Impairment in processing visual information at the pre-attentive stage in patients with a major depressive disorder: A visual mismatch negativity study

Neuroscience Letters ◽

10.1016/j.neulet.2011.01.006 ◽

2011 ◽

Vol 491 (1) ◽

pp. 53-57 ◽

Cited By ~ 24

Author(s):

Xiaohui Qiu ◽

Xiuxian Yang ◽

Zhengxue Qiao ◽

Lin Wang ◽

Nan Ning ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Mismatch Negativity ◽

Visual Information ◽

Major Depressive ◽

Visual Mismatch Negativity

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Real-Time Functional Magnetic Resonance Imaging Amygdala Neurofeedback Changes Positive Information Processing in Major Depressive Disorder

Biological Psychiatry ◽

10.1016/j.biopsych.2017.03.013 ◽

2017 ◽

Vol 82 (8) ◽

pp. 578-586 ◽

Cited By ~ 32

Author(s):

Kymberly D. Young ◽

Masaya Misaki ◽

Catherine J. Harmer ◽

Teresa Victor ◽

Vadim Zotev ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Major Depressive Disorder ◽

Information Processing ◽

Magnetic Resonance ◽

Functional Magnetic Resonance Imaging ◽

Depressive Disorder ◽

Functional Magnetic Resonance ◽

Resonance Imaging ◽

Positive Information ◽

Major Depressive

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Association between increased serum interleukin-6 levels and sustained attention deficits in patients with major depressive disorder

Psychological Medicine ◽

10.1017/s0033291718000090 ◽

2018 ◽

Vol 48 (15) ◽

pp. 2508-2514 ◽

Cited By ~ 8

Author(s):

Gang Ye ◽

Guang Zhong Yin ◽

Zhen Tang ◽

Jia Lin Fu ◽

Jie Chen ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Sustained Attention ◽

Interleukin 6 ◽

Visual Information ◽

Serum Levels ◽

Multivariate Regression Analysis ◽

Healthy Controls ◽

Major Depressive ◽

Control Study

AbstractBackgroundThe pathophysiology of cognitive impairment in patients with the major depressive disorder (MDD) may involve neuroinflammation mediated by cytokines.ObjectiveThe aim of this study was to examine the serum interleukin-6 (IL-6) levels, sustained attention, and their association in patients with MDD.MethodsThirty patients with MDD and 30 healthy controls were enrolled in this case-control study. Sustained attention was measured using the Rapid Visual Information Processing (RVP) task in the Cambridge Neuropsychological Tests Automated Battery. The serum IL-6 levels of all subjects were assessed by sandwich enzyme-linked immunosorbent assays.ResultsThere were significant differences in the log10RVP total hits, log10RVP total misses, and log10RVP mean latency between patients with MDD and healthy controls (F= 6.04,p= 0.017;F= 19.77,p< 0.0001;F= 14.42,p< 0.0001, respectively). The serum levels of Log10IL-6 were significantly higher in patients with MDD than in healthy controls (F= 192.27,p< 0.0001). The log10IL-6 levels were also positively correlated with the log10RVP mean latency in patients with MDD (r= 0.45,p= 0.013). A further stepwise multivariate regression analysis indicated that the log10IL-6 levels were significantly associated with the log10RVP mean latency in patients with MDD (β= 0.31,t= 2.41,p= 0.025).ConclusionsOur data suggested that increased IL-6 levels were associated with the psychopathology of MDD, and that abnormal IL-6 levels were implicated in the impairment of sustained attention in patients with MDD.

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