816. Striatal Dopamine D2/D3 Receptor Availability Predicts Episodic Verbal Memory and Executive Function in Medication-Free Major Depressive Disorder Patients

2017 ◽  
Vol 81 (10) ◽  
pp. S331
Author(s):  
Joseph Kim ◽  
Sara Weisenbach ◽  
Erich Avery ◽  
Joseph Heffernan ◽  
Marta Pecina ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Executive Function ◽  
Depressive Disorder ◽  
Verbal Memory ◽  
Striatal Dopamine ◽  
D3 Receptor ◽  
Major Depressive ◽  
Dopamine D2

Striatal dopamine D2 receptors in medication-naive patients with major depressive disorder as assessed with [11C]raclopride PET

2008 ◽  
Vol 197 (4) ◽  
pp. 581-590 ◽  
Author(s):  
Jussi Hirvonen ◽  
Hasse Karlsson ◽  
Jaana Kajander ◽  
Juha Markkula ◽  
Helena Rasi-Hakala ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
D2 Receptors ◽  
Dopamine D2 Receptors ◽  
Striatal Dopamine ◽  
Major Depressive ◽  
Dopamine D2

scholarly journals Impact of Repetitive Transcranial Magnetic Stimulation (rTMS) on Theory of Mind and Executive Function in Major Depressive Disorder and Its Correlation with Brain-Derived Neurotrophic Factor (BDNF): A Randomized, Double-Blind, Sham-Controlled Trial

2021 ◽  
Vol 11 (6) ◽  
pp. 765
Author(s):  
Jie Tong ◽  
Jie Zhang ◽  
Ying Jin ◽  
Weiqing Liu ◽  
Hao Wang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Executive Function ◽  
Transcranial Magnetic Stimulation ◽  
Theory Of Mind ◽  
Depressive Disorder ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Major Depressive ◽  
Double Blind ◽  
Perseverative Errors

Background: Studies have implicated hypofrontality in the pathogenesis of impaired theory of mind (ToM) and executive function (EF) in major depressive disorder (MDD). These symptoms are usually resistant to treatment. Repetitive transcranial magnetic stimulation (rTMS) has been shown to reverse hypofrontality. Moreover, BDNF is an effective biomarker of antidepressant effects, but there have been very few studies on the correlation between BDNF and rTMS. We aimed to evaluate the efficacy of 20 sessions of a 10 Hz unilateral rTMS intervention over the left dorsolateral prefrontal cortex (DLPFC) in improving ToM and EF in patients with MDD and its correlation with BDNF. Methods: A total of 120 MDD patients were enrolled in this randomized, sham-controlled, double-blind trial. Each participant received 20 sessions of rTMS at 10 Hz frequency through the active or the sham coil over 4 weeks. ToM was assessed with the facial emotion identification test (FEIT) and hinting task (HT). EF was assessed with the Wisconsin card sorting test (WCST). BDNF assessments were carried out at baseline and 2-, 4-, 12-, and 24-week follow-ups. Results: The improvement in the ToM (FEIT, HT) in the active rTMS group was significantly different from that in the sham rTMS group (F = 18.09, p < 0.001; F = 5.02, p = 0.026). There were significant differences in the WCST (categories completed, response errors, response perseverative errors, non-response perseverative errors) after logarithmic transformation at different time points in the active rTMS group (F = 14.71, p < 0.001; F = 5.99, p = 0.046; F = 8.90, p = 0.031; F = 2.31, p = 0.048). However, there was no significant difference in log transformed BDNF concentration between the two groups (t = 0.07 to t = 1.29, p > 0.05). BDNF was negatively correlated with WCST categories completed at the 24th week (r = −0.258, p = 0.046). Conclusions: The results show that rTMS may improve the ToM and EF of patients with MDD and there was no significant correlation with serum BDNF concentration. RTMS can not only be used for treatment of patients with MDD but also has a positive effect on ToM and EF.

scholarly journals Assessment of Striatal Dopamine Transporter Binding in Individuals With Major Depressive Disorder

2019 ◽  
Vol 76 (8) ◽  
pp. 854 ◽  
Author(s):  
Diego A. Pizzagalli ◽  
Sabina Berretta ◽  
Dustin Wooten ◽  
Franziska Goer ◽  
Kanoelani T. Pilobello ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Dopamine Transporter ◽  
Striatal Dopamine ◽  
Major Depressive

A five-times repeated verbal memory test revealed difference between bipolar disorder and major depressive disorder

2010 ◽  
Vol 68 ◽  
pp. e318
Author(s):  
Jun Iwatani ◽  
Masahiro Yamamoto ◽  
Satoshi Ukai ◽  
Tomikimi Tsuji ◽  
Sayuri Kubo ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Verbal Memory ◽  
Memory Test ◽  
Major Depressive

scholarly journals Does Duloxetine Improve Cognitive Function Independently of Its Antidepressant Effect in Patients with Major Depressive Disorder and Subjective Reports of Cognitive Dysfunction?

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Tracy L. Greer ◽  
Prabha Sunderajan ◽  
Bruce D. Grannemann ◽  
Benji T. Kurian ◽  
Madhukar H. Trivedi
Keyword(s):  
Decision Making ◽  
Major Depressive Disorder ◽  
Executive Function ◽  
Depressive Disorder ◽  
Learning And Memory ◽  
Cognitive Deficits ◽  
Verbal Learning ◽  
Small Sample ◽  
Major Depressive ◽  
Response Control

Introduction. Cognitive deficits are commonly reported by patients with major depressive disorder (MDD). Duloxetine, a dual serotonin/noradrenaline reuptake inhibitor, may improve cognitive deficits in MDD. It is unclear if cognitive improvements occur independently of antidepressant effects with standard antidepressant medications.Methods. Thirty participants with MDD who endorsed cognitive deficits at screening received 12-week duloxetine treatment. Twenty-one participants completed treatment and baseline and posttreatment cognitive testing. The Cambridge Neuropsychological Test Automated Battery was used to assess the following cognitive domains: attention, visual memory, executive function/set shifting and working memory, executive function/spatial planning, decision making and response control, and verbal learning and memory.Results. Completers showed significant cognitive improvements across several domains on tasks assessing psychomotor function and mental processing speed, with additional improvements in visual and verbal learning and memory, and affective decision making and response control. Overall significance tests for executive function tasks were also significant, although individual tasks were not, perhaps due to the small sample size. Most notably, cognitive improvements were observed independently of symptom reduction on all domains except verbal learning and memory.Conclusions. Patients reporting baseline cognitive deficits achieved cognitive improvements with duloxetine treatment, most of which were independent of symptomatic improvement. This trial is registered withNCT00933439.

scholarly journals Striatal Dopamine D2/D3 Receptor Availability Is Associated with Executive Function in Healthy Controls but Not Methamphetamine Users

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0143510 ◽  
Author(s):  
Michael E. Ballard ◽  
Andy C. Dean ◽  
Mark A. Mandelkern ◽  
Edythe D. London
Keyword(s):  
Executive Function ◽  
Striatal Dopamine ◽  
Healthy Controls ◽  
D3 Receptor ◽  
Dopamine D2

scholarly journals Cognitive impairment in euthymic major depressive disorder: a meta-analysis

2012 ◽  
Vol 43 (10) ◽  
pp. 2017-2026 ◽  
Author(s):  
E. Bora ◽  
B. J. Harrison ◽  
M. Yücel ◽  
C. Pantelis
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Cognitive Deficits ◽  
Verbal Memory ◽  
Age Of Onset ◽  
Late Onset ◽  
Meta Analysis ◽  
Healthy Controls ◽  
Major Depressive ◽  
Speed Of Information Processing

BackgroundThere is evidence to suggest that cognitive deficits might persist beyond the acute stages of illness in major depressive disorder (MDD). However, the findings are somewhat inconsistent across the individual studies conducted to date. Our aim was to conduct a systematic review and meta-analysis of existing studies that have examined cognition in euthymic MDD patients.MethodFollowing a systematic search across several publication databases, meta-analyses were conducted for 27 empirical studies that compared euthymic adult MDD patients (895 participants) and healthy controls (997 participants) across a range of cognitive domains. The influence of demographic variables and confounding factors, including age of onset and recurrent episodes, was examined.ResultsCompared with healthy controls, euthymic MDD patients were characterized by significantly poorer cognitive functions. However, the magnitude of observed deficits, with the exception of inhibitory control, were generally modest when late-onset cases were excuded. Late-onset cases demonstrated significantly more pronounced deficits in verbal memory, speed of information processing and some executive functions.ConclusionsCognitive deficits, especially poor response inhibition, are likely to be persistent features, at least of some forms, of adult-onset MDD. More studies are necessary to examine cognitive dysfunction in remitted psychotic, melancholic and bipolar spectrum MDD. Cognitive deficits overall appear to be more common among patients with late-onset depression, supporting the theories suggesting that possible vascular and neurodegenerative factors play a role in a substantial number of these patients.

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