T137. Determining Patterns of Activity and Functional Connectivity in Emotion Processing and Regulation Neural Circuitry in Offspring at Risk for Bipolar Disorder

AbstractBackgroundPrevious functional magnetic resonance imaging studies in bipolar disorder (BD) have evidenced changes in functional connectivity (FC) in brain areas associated with emotion processing, but how these changes vary with mood state and specific clinical symptoms is not fully understood.MethodsWe investigated resting-state FC between a priori regions of interest (ROIs) from the default-mode network and key structures for emotion processing and regulation in 27 BD patients and 27 matched healthy controls. We further compared connectivity patterns in subgroups of 15 euthymic and 12 non-euthymic patients and tested for correlations of the connectivity strength with measures of mood, anxiety, and rumination tendency. No correction for multiple comparisons was applied given the small population sample and pre-defined target ROIs.ResultsOverall, regardless of mood state, BD patients exhibited increased FC of the left amygdala with left sgACC and PCC, relative to controls. In addition, non-euthymic BD patients showed distinctive decrease in FC between right amygdala and sgACC, whereas euthymic patients showed lower FC between PCC and sgACC. Euthymic patients also displayed increased FC between sgACC and right VLPFC. The sgACC–PCC and sgACC–left amygdala connections were modulated by rumination tendency in non-euthymic patients, whereas the sgACC-VLPFC connection was modulated by both the current mood and tendency to ruminate.ConclusionsOur results suggest that sgACC-amygdala coupling is critically affected during mood episodes, and that FC of sgACC play a pivotal role in mood normalization through its interactions with the VLPFC and PCC. However, these preliminary findings require replication with larger samples of patients.

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60. Predicting Future Affective Lability From Neural Circuitry Function and Gray Matter in Youth at Risk for Bipolar Disorder

Biological Psychiatry ◽

10.1016/j.biopsych.2018.02.077 ◽

2018 ◽

Vol 83 (9) ◽

pp. S24-S25

Author(s):

Michele Bertocci ◽

Lindsay Hanford ◽

Amelia Versace ◽

Kelly Monk ◽

Lisa Bonar ◽

...

Keyword(s):

At Risk ◽

Bipolar Disorder ◽

Gray Matter ◽

Neural Circuitry ◽

Youth At Risk ◽

Affective Lability

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Functional connectivity during masked and unmasked face emotion processing in bipolar disorder

Psychiatry Research Neuroimaging ◽

10.1016/j.pscychresns.2016.10.006 ◽

2016 ◽

Vol 258 ◽

pp. 1-9 ◽

Cited By ~ 2

Author(s):

Wan-Ling Tseng ◽

Laura A. Thomas ◽

Elizabeth Harkins ◽

Joel Stoddard ◽

Carlos A. Zarate ◽

...

Keyword(s):

Bipolar Disorder ◽

Functional Connectivity ◽

Emotion Processing

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Differential patterns of activity and functional connectivity in emotion processing neural circuitry to angry and happy faces in adolescents with and without suicide attempt

Psychological Medicine ◽

10.1017/s0033291712002966 ◽

2013 ◽

Vol 43 (10) ◽

pp. 2129-2142 ◽

Cited By ~ 78

Author(s):

L. A. Pan ◽

S. Hassel ◽

A. M. Segreti ◽

S. A. Nau ◽

D. A. Brent ◽

...

Keyword(s):

Functional Connectivity ◽

Suicide Attempt ◽

Attentional Control ◽

Emotion Processing ◽

Neural Circuitry ◽

Anterior Cingulate ◽

Sensory Cortex ◽

Lower Activity ◽

Primary Sensory Cortex ◽

History Of

BackgroundNeural substrates of emotion dysregulation in adolescent suicide attempters remain unexamined.MethodWe used functional magnetic resonance imaging to measure neural activity to neutral, mild or intense (i.e. 0%, 50% or 100% intensity) emotion face morphs in two separate emotion-processing runs (angry and happy) in three adolescent groups: (1) history of suicide attempt and depression (ATT, n = 14); (2) history of depression alone (NAT, n = 15); and (3) healthy controls (HC, n = 15). Post-hoc analyses were conducted on interactions from 3 group × 3 condition (intensities) whole-brain analyses (p < 0.05, corrected) for each emotion run.ResultsTo 50% intensity angry faces, ATT showed significantly greater activity than NAT in anterior cingulate gyral–dorsolateral prefrontal cortical attentional control circuitry, primary sensory and temporal cortices; and significantly greater activity than HC in the primary sensory cortex, while NAT had significantly lower activity than HC in the anterior cingulate gyrus and ventromedial prefrontal cortex. To neutral faces during the angry emotion-processing run, ATT had significantly lower activity than NAT in the fusiform gyrus. ATT also showed significantly lower activity than HC to 100% intensity happy faces in the primary sensory cortex, and to neutral faces in the happy run in the anterior cingulate and left medial frontal gyri (all p < 0.006,corrected). Psychophysiological interaction analyses revealed significantly reduced anterior cingulate gyral–insula functional connectivity to 50% intensity angry faces in ATT v. NAT or HC.ConclusionsElevated activity in attention control circuitry, and reduced anterior cingulate gyral–insula functional connectivity, to 50% intensity angry faces in ATT than other groups suggest that ATT may show inefficient recruitment of attentional control neural circuitry when regulating attention to mild intensity angry faces, which may represent a potential biological marker for suicide risk.

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Baseline and follow-up activity and functional connectivity in reward neural circuitries in offspring at risk for bipolar disorder

Neuropsychopharmacology ◽

10.1038/s41386-019-0339-2 ◽

2019 ◽

Vol 44 (9) ◽

pp. 1570-1578 ◽

Cited By ~ 4

Author(s):

Heather E. Acuff ◽

Amelia Versace ◽

Michele A. Bertocci ◽

Cecile D. Ladouceur ◽

Lindsay C. Hanford ◽

...

Keyword(s):

At Risk ◽

Bipolar Disorder ◽

Functional Connectivity

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Dissociable patterns of medial prefrontal and amygdala activity to face identity versus emotion in bipolar disorder

Psychological Medicine ◽

10.1017/s0033291711002935 ◽

2012 ◽

Vol 42 (9) ◽

pp. 1913-1924 ◽

Cited By ~ 20

Author(s):

M. T. Keener ◽

J. C. Fournier ◽

B. C. Mullin ◽

D. Kronhaus ◽

S. B. Perlman ◽

...

Keyword(s):

Bipolar Disorder ◽

Face Processing ◽

Emotion Processing ◽

Social Function ◽

Neural Circuitry ◽

Happy Face ◽

Face Identity ◽

Facial Identity ◽

Amygdala Activity ◽

Identity Processing

BackgroundIndividuals with bipolar disorder demonstrate abnormal social function. Neuroimaging studies in bipolar disorder have shown functional abnormalities in neural circuitry supporting face emotion processing, but have not examined face identity processing, a key component of social function. We aimed to elucidate functional abnormalities in neural circuitry supporting face emotion and face identity processing in bipolar disorder.MethodTwenty-seven individuals with bipolar disorder I currently euthymic and 27 healthy controls participated in an implicit face processing, block-design paradigm. Participants labeled color flashes that were superimposed on dynamically changing background faces comprising morphs either from neutral to prototypical emotion (happy, sad, angry and fearful) or from one identity to another identity depicting a neutral face. Whole-brain and amygdala region-of-interest (ROI) activities were compared between groups.ResultsThere was no significant between-group difference looking across both emerging face emotion and identity. During processing of all emerging emotions, euthymic individuals with bipolar disorder showed significantly greater amygdala activity. During facial identity and also happy face processing, euthymic individuals with bipolar disorder showed significantly greater amygdala and medial prefrontal cortical activity compared with controls.ConclusionsThis is the first study to examine neural circuitry supporting face identity and face emotion processing in bipolar disorder. Our findings of abnormally elevated activity in amygdala and medial prefrontal cortex (mPFC) during face identity and happy face emotion processing suggest functional abnormalities in key regions previously implicated in social processing. This may be of future importance toward examining the abnormal self-related processing, grandiosity and social dysfunction seen in bipolar disorder.

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Association of Neuroimaging Measures of Emotion Processing and Regulation Neural Circuitries With Symptoms of Bipolar Disorder in Offspring at Risk for Bipolar Disorder

JAMA Psychiatry ◽

10.1001/jamapsychiatry.2018.2318 ◽

2018 ◽

Vol 75 (12) ◽

pp. 1241 ◽

Cited By ~ 6

Author(s):

Heather E. Acuff ◽

Amelia Versace ◽

Michele A. Bertocci ◽

Cecile D. Ladouceur ◽

Lindsay C. Hanford ◽

...

Keyword(s):

At Risk ◽

Bipolar Disorder ◽

Emotion Processing

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26.3 LONGITUDINAL RELATIONSHIPS AMONG EMOTIONAL REGULATION NEURAL CIRCUITRY FUNCTION AND SYMPTOM SEVERITY IN AT-RISK YOUTH WITH BIPOLAR DISORDER

Journal of the American Academy of Child & Adolescent Psychiatry ◽

10.1016/j.jaac.2016.07.269 ◽

2016 ◽

Vol 55 (10) ◽

pp. S298-S299

Author(s):

Mary L. Phillips ◽

Michele A. Bertocci ◽

Genna Bebko ◽

Amanda Dwojak ◽

Satish Iyengar ◽

...

Keyword(s):

At Risk ◽

Bipolar Disorder ◽

Symptom Severity ◽

Emotional Regulation ◽

Neural Circuitry ◽

At Risk Youth ◽

Longitudinal Relationships

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Aberrant intrinsic functional connectivity within and between corticostriatal and temporal–parietal networks in adults and youth with bipolar disorder

Psychological Medicine ◽

10.1017/s0033291716000143 ◽

2016 ◽

Vol 46 (7) ◽

pp. 1509-1522 ◽

Cited By ~ 33

Author(s):

J. Stoddard ◽

S. J. Gotts ◽

M. A. Brotman ◽

S. Lever ◽

D. Hsu ◽

...

Keyword(s):

Bipolar Disorder ◽

Functional Connectivity ◽

Visual Processing ◽

Age Groups ◽

Neural Circuitry ◽

Brain Regions ◽

Functional Magnetic Resonance ◽

Intrinsic Functional Connectivity ◽

Late Stages ◽

The Brain

BackgroundMajor questions remain regarding the dysfunctional neural circuitry underlying the pathophysiology of bipolar disorder (BD) in both youths and adults. In both age groups, studies implicate abnormal intrinsic functional connectivity among prefrontal, limbic and striatal areas.MethodWe collected resting-state functional magnetic resonance imaging (fMRI) data from youths and adults (ages 10–50 years) with BD (n = 39) and healthy volunteers (HV; n = 78). We identified brain regions with aberrant intrinsic functional connectivity in BD by first comparing voxel-wise mean global connectivity and then conducting correlation analyses. We used k-means clustering and multidimensional scaling to organize all detected regions into networks.ResultsAcross the brain, we detected areas of dysconnectivity in both youths and adults with BD relative to HV. There were no significant age-group × diagnosis interactions. When organized by interregional connectivity, the areas of dysconnectivity in patients with BD comprised two networks: one of temporal and parietal areas involved in late stages of visual processing, and one of corticostriatal areas involved in attention, cognitive control and response generation.ConclusionsThese data suggest that two networks show abnormal intrinsic functional connectivity in BD. Regions in these networks have been implicated previously in BD. We observed similar dysconnectivity in youths and adults with BD. These findings provide guidance for refining models of network-based dysfunction in BD.

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