T161. Long-Term Potentiation-Like Visual Evoked Potential Plasticity in a Large Sample of Healthy Volunteers: Effect Sizes and Response Rates

2018 ◽  
Vol 83 (9) ◽  
pp. S190-S191
Author(s):  
Mathias Valstad ◽  
Torgeir Moberget ◽  
Lars T. Westlye ◽  
Daniël T.H. Roelfs ◽  
Knut Skaug ◽  
...  
2010 ◽  
Vol 117 (2-3) ◽  
pp. 244-245
Author(s):  
Idil Cavus ◽  
Robert Guglielmino ◽  
Judith Ford ◽  
Brian Roach ◽  
John Krystal ◽  
...  

Cephalalgia ◽  
2016 ◽  
Vol 37 (5) ◽  
pp. 418-422 ◽  
Author(s):  
Anna Ambrosini ◽  
Gianluca Coppola ◽  
Ennio Iezzi ◽  
Francesco Pierelli ◽  
Jean Schoenen

Background Many studies have shown that migraine patients have an interictal habituation deficit of visual evoked potentials (VEPs). Some discordant results were attributed to non-blinded analyses and a lack of repeatability. Aims In this study, we compared blinded and non-blinded analyses of the same recordings and assessed test–retest repeatability. Methods VEP recordings of 25 healthy volunteers (HVs) and 78 episodic migraine patients (EMs; 52 interictal, 26 ictal) were analysed by two investigators, one of whom was blinded to diagnosis and headache phase. Twelve HVs and nine EMs had two recordings for test repeatability. Results In both blinded and non-blinded analyses, VEP habituation was normal in HVs and EMs during an attack, but deficient in EMs interictally. Intra-individual habituation percentages were highly correlated in two recordings separated by ≥7 days. Conclusions The studies showing a VEP habituation deficit in migraineurs between attacks are unlikely to be biased by non-blinding analysis or poor repeatability.


NeuroImage ◽  
2020 ◽  
Vol 223 ◽  
pp. 117302
Author(s):  
Mathias Valstad ◽  
Torgeir Moberget ◽  
Daniël Roelfs ◽  
Nora B. Slapø ◽  
Clara M.F. Timpe ◽  
...  

2005 ◽  
Vol 21 (7) ◽  
pp. 2045-2050 ◽  
Author(s):  
Timothy J. Teyler ◽  
Jeff P. Hamm ◽  
Wesley C. Clapp ◽  
Blake W. Johnson ◽  
Michael C. Corballis ◽  
...  

2020 ◽  
Author(s):  
Rachael L. Sumner ◽  
Meg J. Spriggs ◽  
Alexander D. Shaw

AbstractNeuroplasticity is essential to learning and memory in the brain; it has therefore also been implicated in numerous neurological and psychiatric disorders, making measuring the state of neuroplasticity of foremost importance to clinical neuroscience. Long-term potentiation (LTP) is a key mechanism of neuroplasticity and has been studied extensively, and invasively in non-human animals. Translation to human application largely relies on the validation of non-invasive measures of LTP. The current study provides validation for the use of a thalamocortical computational model of visual cortex for investigating and replicating interlaminar connectivity changes using non-invasive EEG recording of humans, and a commonly used visual sensory LTP paradigm. The model demonstrated remarkable accuracy recapitulating post-tetanus changes including increased excitatory connectivity from thalamus to layer IV and from layer IV to II/III. The findings also further validate visual sensory induced LTP and evoked potential modulation for measuring of the state of LTP in cortex.


Author(s):  
Gencai Shen ◽  
Kunpeng Gao ◽  
Nan Zhao ◽  
Zhiran Yi ◽  
Chunpeng Jiang ◽  
...  

Abstract Objective: A novel flexible hydrogel electrode with a strong moisturizing ability was prepared for long-term electroencephalography (EEG) monitoring. Approach: The hydrogel was synthesized by polymerizing the N-acryloyl glycinamide (NAGA) monomer. And a proper amount of glycerin was added to the hydrogel to increase the moisture retention ability of the electrodes. The hydrogel shows high mechanical properties, and the liquid in the hydrogel produces a hydrating effect on the skin stratum corneum, which could decrease the contact impedance between skin and electrode. In addition, the installation of hydrogel electrode is very convenient, and the skin of the subject does not need to be abraded. Main results: SEM images show that there are a large number of micropores in the hydrogel, which provide storage space for water molecules. The average potential drift of the hydrogel electrode is relatively low (1.974 ± 0.560 µV min-1). The average contact impedance of hydrogel electrode in forehead region and hair region are 6.43 ± 0.84 kΩ·cm2 and 13.15 ± 3.72 kΩ·cm2, respectively. The result of open/closed paradigm, steady-state visual evoked potentials (SSVEP), and P300 visual evoked potential show that hydrogel electrode has excellent performance. Compared with the hydrogel without glycerol, the moisture retention ability of hydrogel with glycerol was greatly improved. Significance. Compared with standard Ag/AgCl wet electrode, hydrogel electrode is more convenient to install and has strong moisture retention ability, which makes it have great potential in daily life for long-term EEG recording.


2017 ◽  
Vol 6 (0) ◽  
pp. 59-67 ◽  
Author(s):  
Mariko Kuwabara ◽  
Hiroyuki Tashiro ◽  
Yasuo Terasawa ◽  
Koji Osawa ◽  
Takashi Tokuda ◽  
...  

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