CVN058, a 5-HT3 Receptor Antagonist, Shows Acute, Dose Dependent Improvement of Mismatch Negativity in a Double-Blind, Placebo-Controlled, Single Dose Cross-Over Study in Schizophrenia and Schizoaffective Disorder

Pejman Sehatpour; Heloise De Baun; Daniel Javitt; David Margolin; Nicola Brice; Mark Carlton; Lee Dawson; Roland Burli; Marlene Carlson; Joshua Kantrowitz

doi:10.1016/j.biopsych.2021.02.086

CVN058, a 5-HT3 Receptor Antagonist, Shows Acute, Dose Dependent Improvement of Mismatch Negativity in a Double-Blind, Placebo-Controlled, Single Dose Cross-Over Study in Schizophrenia and Schizoaffective Disorder

Biological Psychiatry ◽

10.1016/j.biopsych.2021.02.086 ◽

2021 ◽

Vol 89 (9) ◽

pp. S27

Author(s):

Pejman Sehatpour ◽

Heloise De Baun ◽

Daniel Javitt ◽

David Margolin ◽

Nicola Brice ◽

...

Keyword(s):

Single Dose ◽

Receptor Antagonist ◽

Schizoaffective Disorder ◽

Mismatch Negativity ◽

Double Blind ◽

Double Blind Placebo ◽

Acute Dose ◽

Dose Dependent

Download Full-text

Mismatch negativity as an index of target engagement for excitation/inhibition-based treatment development: a double-blind, placebo-controlled, randomized, single-dose cross-over study of the serotonin type-3 receptor antagonist CVN058

Neuropsychopharmacology ◽

10.1038/s41386-021-01170-8 ◽

2021 ◽

Author(s):

Pejman Sehatpour ◽

Daniel C. Javitt ◽

Heloise M. De Baun ◽

Marlene Carlson ◽

Anna Beloborodova ◽

...

Keyword(s):

Single Dose ◽

Receptor Antagonist ◽

Mismatch Negativity ◽

Target Engagement ◽

Double Blind ◽

Treatment Development ◽

Double Blind Placebo ◽

Type 3

Download Full-text

Dose-dependent enhancement of motor activation and motor skills by a single dose of paroxetine, a serotonin reuptake inhibitor. A double-blind, placebo-controlled fMRI study in healthy subjects

NeuroImage ◽

10.1016/s1053-8119(01)92533-9 ◽

2001 ◽

Vol 13 (6) ◽

pp. 1218

Author(s):

Isabelle Loubinoux ◽

Jeremie Pariente ◽

Christophe Carel ◽

Claude Manelfe ◽

Olivier Rascol ◽

...

Keyword(s):

Single Dose ◽

Motor Skills ◽

Reuptake Inhibitor ◽

Serotonin Reuptake ◽

Healthy Subjects ◽

Double Blind ◽

Double Blind Placebo ◽

Motor Activation ◽

Fmri Study ◽

Dose Dependent

Download Full-text

Faculty Opinions recommendation of Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.738855507.793582808 ◽

2021 ◽

Author(s):

Linda Parker

Keyword(s):

Healthy Subjects ◽

Lysergic Acid ◽

Lysergic Acid Diethylamide ◽

Controlled Study ◽

Double Blind ◽

Double Blind Placebo ◽

Acute Dose ◽

Dose Dependent

Download Full-text

Faculty Opinions recommendation of Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2).

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13198963.14726480 ◽

2011 ◽

Author(s):

Luciana Mascia ◽

Ilaria Mastromauro

Keyword(s):

Subarachnoid Haemorrhage ◽

Receptor Antagonist ◽

Endothelin Receptor Antagonist ◽

Aneurysmal Subarachnoid Haemorrhage ◽

Endothelin Receptor ◽

Surgical Clipping ◽

Phase 3 ◽

Double Blind ◽

Double Blind Placebo

Download Full-text

Faculty Opinions recommendation of Dose-dependent effects of omega-3-polyunsaturated fatty acids on systolic left ventricular function, endothelial function, and markers of inflammation in chronic heart failure of nonischemic origin: a double-blind, placebo-controlled, 3-arm study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717297963.792752819 ◽

2012 ◽

Author(s):

David Taylor ◽

Ethan Anderson

Keyword(s):

Heart Failure ◽

Fatty Acids ◽

Chronic Heart Failure ◽

Left Ventricular ◽

Omega 3 ◽

Double Blind ◽

Double Blind Placebo ◽

Systolic Left Ventricular Function ◽

Markers Of Inflammation ◽

Dose Dependent

Download Full-text

Faculty Opinions recommendation of P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725255169.793503497 ◽

2015 ◽

Author(s):

Brendan J Canning

Keyword(s):

Receptor Antagonist ◽

Chronic Cough ◽

Phase 2 ◽

P2x3 Receptor ◽

Double Blind ◽

Double Blind Placebo ◽

Phase 2 Study

Download Full-text

Efficacy of leukotriene receptor antagonist in chronic urticaria. A double-blind, placebo-controlled comparison of treatment with montelukast and cetirizine in patients with chronic urticaria with intolerance to food additive and/or acetylsalicylic acid

Clinical & Experimental Allergy ◽

10.1046/j.1365-2222.2001.01189.x ◽

2001 ◽

Vol 31 (10) ◽

pp. 1607-1614 ◽

Cited By ~ 109

Author(s):

M. L. Pacor ◽

G. Di Lorenzo ◽

R. Corrocher

Keyword(s):

Acetylsalicylic Acid ◽

Receptor Antagonist ◽

Chronic Urticaria ◽

Food Additive ◽

Leukotriene Receptor Antagonist ◽

Double Blind ◽

Double Blind Placebo ◽

Leukotriene Receptor

Download Full-text

Correction to: A single dose of purple grape juice improves physical performance and antioxidant activity in runners: a randomized, crossover, double-blind, placebo study

European Journal of Nutrition ◽

10.1007/s00394-020-02453-4 ◽

2020 ◽

Author(s):

Lydiane de Lima Tavares Toscano ◽

Alexandre Sérgio Silva ◽

Ana Carla Lima de França ◽

Bruno Rafael Virgínio de Sousa ◽

Eder Jackson Bezerra de Almeida Filho ◽

...

Keyword(s):

Antioxidant Activity ◽

Single Dose ◽

Physical Performance ◽

Grape Juice ◽

Double Blind ◽

Double Blind Placebo

The article A single dose of purple grape juice improves physical performance and antioxidant activity in runners.

Download Full-text

A single dose zoledronic acid enhances pin fixation in high tibial osteotomy using the hemicallotasis technique. A double-blind placebo controlled randomized study in 46 patients

Bone ◽

10.1016/j.bone.2009.10.040 ◽

2010 ◽

Vol 46 (3) ◽

pp. 649-654 ◽

Cited By ~ 11

Author(s):

Anna Kajsa Harding ◽

Sören Toksvig-Larsen ◽

Magnus Tägil ◽

Annette W-Dahl

Keyword(s):

Single Dose ◽

Zoledronic Acid ◽

High Tibial Osteotomy ◽

Randomized Study ◽

Tibial Osteotomy ◽

Double Blind ◽

Double Blind Placebo ◽

Pin Fixation

Download Full-text

High-dose sublingual immunotherapy with single-dose aqueous grass pollen extract in children is effective and safe: A double-blind, placebo-controlled study

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2012.06.047 ◽

2012 ◽

Vol 130 (4) ◽

pp. 886-893.e5 ◽

Cited By ~ 53

Author(s):

Ulrich Wahn ◽

Ludger Klimek ◽

Anna Ploszczuk ◽

Thomas Adelt ◽

Bernhard Sandner ◽

...

Keyword(s):

Single Dose ◽

Grass Pollen ◽

Sublingual Immunotherapy ◽

Controlled Study ◽

High Dose ◽

Pollen Extract ◽

Double Blind ◽

Double Blind Placebo

Download Full-text