AuNPs/CNOs/SWCNTs/chitosan-nanocomposite modified electrochemical sensor for the label-free detection of carcinoembryonic antigen

2018 ◽  
Vol 107 ◽  
pp. 211-217 ◽  
Author(s):  
Mohammad Rizwan ◽  
Syazwani Elma ◽  
Syazana Abdullah Lim ◽  
Minhaz Uddin Ahmed
Keyword(s):  
Electrochemical Sensor ◽  
Carcinoembryonic Antigen ◽  
Label Free ◽  
Label Free Detection

Disposable paper-based electrochemical sensor using thiol-terminated poly(2-methacryloyloxyethyl phosphorylcholine) for the label-free detection of C-reactive protein

2019 ◽  
Vol 186 (7) ◽  
Author(s):  
Chanika Pinyorospathum ◽  
Sudkate Chaiyo ◽  
Pornpen Sae-ung ◽  
Voravee P. Hoven ◽  
Panittha Damsongsang ◽  
...  
Keyword(s):  
Electrochemical Sensor ◽  
Label Free ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Label Free Detection

scholarly journals New Ultrasensitive Sandwich-Type Immunoassay of Dendritic Tri-Fan Blade-like PdAuCu Nanoparticles/Amine-Functionalized Graphene Oxide for Label-Free Detection of Carcinoembryonic Antigen

Micromachines ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1256
Author(s):  
Pingping Xu ◽  
Wenpo Feng ◽  
Mei Wang ◽  
Ling Zhang ◽  
Gaofeng Liang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Carcinoembryonic Antigen ◽  
Au Nanoparticle ◽  
Functionalized Graphene ◽  
Label Free ◽  
Functionalized Graphene Oxide ◽  
Amine Functionalized ◽  
Label Free Detection ◽  
Sandwich Type ◽  
Fan Blade

The early detection of tumor markers has an effective role in the treatment of cancer. Here, a new sandwich-type electrochemical immunosensor for early label-free detection of the cancer biomarker carcinoembryonic antigen (CEA) was developed. Dendritic tri-fan blade-like PdAuCu nanoparticles (PdAuCu NPs)/amine functionalized graphene oxide (NH2-GO) were the label of secondary antibodies (Ab2), and Au nanoparticle-decorated polydopamines (Au/PDA) were immobilized on a screen-printed carbon electrode (SPCE) as the substrate materials. Dendritic tri-fan blade-like PdAuCu NPs/NH2-GO was synthesized according to a simple hydrothermal procedure and used to immobilize antibodies (Ab2) with large surfaces areas, increased catalytic properties and good adsorption to amplify the current signals. Subsequently, Ab2/PdAuCu NPs/NH2-GO catalyzed the reduction of H2O2 in the sandwich-type immunoreactions. Under optimal conditions, the immunosensor exhibited a satisfactory response to CEA with a limit detection of 0.07 pg mL−1 and a linear detection range from 0.1 pg mL−1 to 200 ng mL−1. The proposed immunosensor could be suitable enough for a real sample analysis of CEA, and has clinical value in the early diagnosis of cancer.

scholarly journals Label-free Electrochemical Impedance Spectroscopy Aptasensor for Ultrasensitive Detection of Lung Cancer Biomarker Carcinoembryonic Antigen

2021 ◽  
Vol 9 ◽  
Author(s):  
Yawei Wang ◽  
Lei Chen ◽  
Tiantian Xuan ◽  
Jian Wang ◽  
Xiuwen Wang
Keyword(s):  
Carcinoembryonic Antigen ◽  
Self Assembly ◽  
Electrochemical Impedance ◽  
Reference Electrode ◽  
Electrode System ◽  
Impedance Change ◽  
Label Free ◽  
Working Electrode ◽  
Label Free Detection ◽  
Assembly Technique

In this work, an integrated electrode system consisting of a graphene working electrode, a carbon counter electrode and an Ag/AgCl reference electrode was fabricated on an FR-4 glass fiber plate by a polyethylene self-adhesive mask stencil method combined with a manual screen printing technique. The integrated graphene electrode was used as the base electrode, and AuNPs were deposited on the working electrode surface by cyclic voltammetry. Then, the carcinoembryonic antigen aptamer was immobilized using the sulfhydryl self-assembly technique. The sensor uses [Fe(CN)6]3−/4− as a redox probe for label free detection of carcinoembryonic antigen based on the impedance change caused by the difference in electron transfer rate before and after the binding of carcinoembryonic antigen aptamer and the target carcinoembryonic antigen. The results showed a good linear relationship when the CEA concentration is in the range of 0.2–15.0 ng/ml. The detection limit was calculated to be 0.085 ng/ml (S/N = 3).

scholarly journals Reagentless and sensitive determination of carcinoembryonic antigen based on a stable Prussian blue modified electrode

RSC Advances ◽  
2020 ◽  
Vol 10 (63) ◽  
pp. 38316-38322
Author(s):  
Jing Lin ◽  
Kunyin Li ◽  
Meifang Wang ◽  
Xiaohong Chen ◽  
Jiyang Liu ◽  
...  
Keyword(s):  
Electrochemical Sensor ◽  
Carcinoembryonic Antigen ◽  
Prussian Blue ◽  
Modified Electrode ◽  
Sensitive Detection ◽  
Label Free ◽  
Sensitive Determination

A label-free electrochemical sensor is easily fabricated based on stable and surface-confined Prussian blue for reagentless and sensitive detection of carcinoembryonic antigen.

A label-free electrochemical sensor for ultrasensitive microRNA-21 analysis based on poly(l-cysteine)/MoS2 sensing interface

The Analyst ◽  
2021 ◽  
Author(s):  
Yao Yao ◽  
Hemeng Pan ◽  
Yi Luo ◽  
Dan Zhu ◽  
Jie Chao ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Electrochemical Sensor ◽  
Molybdenum Disulfide ◽  
Label Free ◽  
Label Free Detection

Label-free detection of nucleic acids attracts scientists’ interests due to its simple, fast and efficient. Herein, l-cysteine was electropolymerized on molybdenum disulfide (MoS2) surface to form a stable and electroactive...

Rapid, sensitive and label-free detection of pathogenic bacteria using a bacteria-imprinted conducting polymer film-based electrochemical sensor

Talanta ◽  
2021 ◽  
Vol 226 ◽  
pp. 122135
Author(s):  
Ruinan Wang ◽  
Lingling Wang ◽  
Juan Yan ◽  
Donglei Luan ◽  
Tao sun ◽  
...  
Keyword(s):  
Electrochemical Sensor ◽  
Polymer Film ◽  
Conducting Polymer ◽  
Pathogenic Bacteria ◽  
Label Free ◽  
Label Free Detection
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