Synthesis and biological evaluation of cytotoxic activity of novel anthracene l-rhamnopyranosides

2010 ◽  
Vol 18 (14) ◽  
pp. 5183-5193 ◽  
Author(s):  
Gaopeng Song ◽  
Hongchun Liu ◽  
Wei Zhang ◽  
Meiyu Geng ◽  
Yingxia Li
Keyword(s):  
Cytotoxic Activity ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of acylated oligorhamnoside derivatives structurally related to mezzettiaside-6 with cytotoxic activity

2016 ◽  
Vol 14 (28) ◽  
pp. 6691-6702 ◽  
Author(s):  
Gaopeng Song ◽  
Sumei Li ◽  
Zhiwei Lei ◽  
Yibin Li ◽  
Junhua Li ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Natural Product ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Two partially acylated oligorhamnoside derivatives 1 and 2 structurally related to the natural product mezzettiaside-6 were synthesized via a ‘2 + 1 + 1’ convergent strategy.

Synthesis and Biological Evaluation of a New Chalconate Co (II/III) Complex with Cytotoxic Activity

2021 ◽  
pp. 131567
Author(s):  
Manos C. Vlasiou ◽  
Kyriacos Ioannou ◽  
Constantina Eleftheriou ◽  
Kyriaki S. Pafiti ◽  
Lefteris C. Zacharia ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Synthesis and Biological Evaluation of Novel Chloroethylaminoanthraquinones with Potent Cytotoxic Activity against Cisplatin-Resistant Tumor Cells

2004 ◽  
Vol 47 (7) ◽  
pp. 1856-1859 ◽  
Author(s):  
Klaus Pors ◽  
Zennia Paniwnyk ◽  
Ketan C. Ruparelia ◽  
Paul H. Teesdale-Spittle ◽  
John A. Hartley ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Tumor Cells ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of new 1,5-diazaanthraquinones with cytotoxic activity

2004 ◽  
Vol 12 (24) ◽  
pp. 6505-6515 ◽  
Author(s):  
Sonia Manzanaro ◽  
María Jesús Vicent ◽  
María Jesús Martín ◽  
Nélida Salvador-Tormo ◽  
José María Pérez ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and Biological Evaluation of Oseltamivir Analogues from Shikimic Acid

2014 ◽  
Vol 9 (7) ◽  
pp. 1934578X1400900
Author(s):  
Van Hung Nguyen ◽  
Van Cuong Pham ◽  
Thi Thao Do ◽  
Huong Doan Thi Mai ◽  
Nguyen Thanh Le ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Influenza A ◽  
Shikimic Acid ◽  
Human Cancer ◽  
Biological Evaluation ◽  
Inhibition Activity ◽  
Azide Group ◽  
Human Cancer Cell Lines ◽  
Synthesis And Biological Evaluation

New oseltamivir analogues were designed and synthesized, starting from shikimic acid. Biological evaluation against three human cancer cell lines (KB, MCF7 and Lu-1) showed that many of them exhibited cytotoxic activity. Azides 5 are more active than the corresponding amines 6. Thus, the reduction of the azide group into amine led to the loss of cytotoxicity. The compounds with a cyclohexanemethyloxy group at C-3 were more active than the other investigated compounds belonging to the same series. This cyclohexanemethyloxy group seems to be critical for the cytotoxic activity of this class of compounds. The synthetic oseltamivir analogues 6a-e had no inhibition activity, even at the concentration of 50 μM when they were evaluated for their in vitro influenza A neuraminidase inhibitory activity by an enzymatic assay.

Synthesis and biological evaluation of piperazine group-linked bivalent β-carbolines as potential antitumor agents

MedChemComm ◽  
2015 ◽  
Vol 6 (12) ◽  
pp. 2170-2174 ◽  
Author(s):  
Rongqin Sun ◽  
Rui Liu ◽  
Chi Zhou ◽  
Zhenghua Ren ◽  
Liang Guo ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Antitumor Agents ◽  
Biological Evaluation ◽  
Cytotoxic Activities ◽  
Synthesis And Biological Evaluation ◽  
Potential Antitumor

A series of bivalent β-carbolines with a piperazine group spacer between 3-methylene units were synthesized and their cytotoxic activities in vitro were evaluated. Compounds 7e and 7g exhibited potent cytotoxic activity.

scholarly journals Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives

2013 ◽  
Vol 63 (2) ◽  
pp. 175-191 ◽  
Author(s):  
Ivan Kos ◽  
Milena Jadrijević-Mladar ◽  
Ivan Butula ◽  
Mladen Biruš ◽  
Gordana Maravić-Vlahoviček ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Antibacterial Activities ◽  
Biological Evaluation ◽  
Acute Monocytic Leukemia ◽  
Monocytic Leukemia ◽  
No Donors ◽  
E Coli ◽  
Activity Evaluation ◽  
Isocyanuric Acid ◽  
Synthesis And Biological Evaluation

5 Synthesis and biological evaluation of a series (N = 16) of cyclic and acyclic hydroxyurea derivatives, including benzotriazole-, isocyanuric acid- and biuret-containing compounds, are disclosed. 1-N-(benzyloxycarbamoyl)benzotriazole was used as a benzyloxyisocyanate donor, a useful intermediate in the preparation of substituted hydroxyurea. Antibacterial activities of synthesized hydroxyurea derivatives were tested on three E. coli strains, i.e., a strain susceptible to antibiotics, a strain resistant to macrolide antibiotics and a strain resistant to aminoglycoside antibiotics. Six compounds (three acyclic and three cyclic hydroxyureas) showed growth inhibition of the tested E. coli strains, with different specificity toward each strain. Results of the cytotoxic activity evaluation revealed that twelve out of sixteen test compounds were cytotoxic to human acute monocytic leukemia THP-1 and/or human acute T cell leukemia Jurkat cell line. 1-(N-hydroxycarbamoyl) benzotriazole () increased the metabolic activity of both cell lines. Two compounds, 1-(N-hydroxycarbamoyl) benzotriazole (5) and N,N’,N’’-trihydroxybiuret (15), were identified as potential NO donors.

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