Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis

2021 ◽  
pp. 116292
Author(s):  
Ryota Kitakami ◽  
Kishin Inui ◽  
Yusuke Nakagawa ◽  
Yurika Sawai ◽  
Wakana Katayama ◽  
...  
Keyword(s):  
Xanthone Derivatives ◽  
Inhibitory Activities

scholarly journals QSAR STUDY OF XANTHONE DERIVATIVES AS ANTI PLASMODIAL AGENTS

2010 ◽  
Vol 10 (3) ◽  
pp. 357-362 ◽  
Author(s):  
Amanatie Amanatie ◽  
Jumina Jumina ◽  
Mustofa Mustofa ◽  
M. Hanafi ◽  
Ria Armunanto
Keyword(s):  
Predictive Power ◽  
Qsar Model ◽  
Linear Regression Method ◽  
Deep Insight ◽  
Qsar Study ◽  
Xanthone Derivatives ◽  
Qsar Models ◽  
Inhibitory Activities ◽  
Semi Empirical ◽  
Insight Into

Xanthones and their derivatives have been reported to exhibit inhibitory activities towards Plasmodium falciparum. To provide deep insight into the correlation between inhibitory activities and structures of xanthones, linear regression method was employed to establish QSAR models for 16 xanthone derivatives that have diverse structures. The accuracy and predictive power of the proposed QSAR model were verified by semi empirical PM3 method, optimation, and validation. The result showed that the best model is model 3 i.e. Log 1/IC50 = Σ (-1.446)qO(7)+ (-8.775)q.C(12) + (-10.592)qC(13) + 1,979; Y = PRESS = 1.124192.

scholarly journals Synthesis and Nitric Oxide Inhibitory Activities of New Xanthone Derivatives

2018 ◽  
Vol 9 ◽  
Author(s):  
Zi Han Loh ◽  
Siau Hui Mah ◽  
Soek Sin Teh ◽  
Gwendoline Cheng Lian Ee
Keyword(s):  
Nitric Oxide ◽  
Xanthone Derivatives ◽  
Inhibitory Activities

Synthesis, inhibitory activities, and QSAR study of xanthone derivatives as α-glucosidase inhibitors

2008 ◽  
Vol 16 (15) ◽  
pp. 7185-7192 ◽  
Author(s):  
Yan Liu ◽  
Zhuofeng Ke ◽  
Jianfang Cui ◽  
Wen-Hua Chen ◽  
Lin Ma ◽  
...  
Keyword(s):  
Qsar Study ◽  
Xanthone Derivatives ◽  
Glucosidase Inhibitors ◽  
Inhibitory Activities
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