Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomers

2010 ◽  
Vol 20 (1) ◽  
pp. 56-59 ◽  
Author(s):  
Jingjing Yao ◽  
Qingye Zhang ◽  
Jun Min ◽  
Jin He ◽  
Ziniu Yu
Keyword(s):  
Escherichia Coli ◽  
Chinese Medicine ◽  
Enoyl Acp Reductase ◽  
Potential Inhibitors

Screening of Some Essential Oil Constituents as Potential Inhibitors of the ATP Synthase of Escherichia coli

2018 ◽  
Vol 84 (1) ◽  
pp. 138-146 ◽  
Author(s):  
Daniella Issa ◽  
Amal Najjar ◽  
Hélène Greige-Gerges ◽  
Hala Nehme
Keyword(s):  
Escherichia Coli ◽  
Essential Oil ◽  
Atp Synthase ◽  
Potential Inhibitors

The search of potential inhibitors of the AcrAB–TolC system of multidrug-resistant Escherichia coli: an in silico approach

2019 ◽  
Vol 103 (15) ◽  
pp. 6309-6318 ◽  
Author(s):  
Heba Abdel-Halim ◽  
Ala’a Al Dajani ◽  
Abeer Abdelhalim ◽  
Suzanne Abdelmalek
Keyword(s):  
Escherichia Coli ◽  
In Silico ◽  
Multidrug Resistant ◽  
Potential Inhibitors

The food-grade antimicrobial xanthorrhizol targets the enoyl-ACP reductase (FabI) in Escherichia coli

2020 ◽  
Vol 30 (24) ◽  
pp. 127651
Author(s):  
Yogiara ◽  
Elena A. Mordukhova ◽  
Dooil Kim ◽  
Won-Gon Kim ◽  
Jae-Kwan Hwang ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Food Grade ◽  
Enoyl Acp Reductase

Crystallization and Preliminary X-ray Diffraction Studies of the Enoyl-ACP Reductase from Escherichia coli

1994 ◽  
Vol 243 (1) ◽  
pp. 126-127 ◽  
Author(s):  
Ulrike G. Wagner ◽  
Helmut Bergler ◽  
Sandra Fuchsbichler ◽  
Friederike Turnowsky ◽  
Gregor Högenauer ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
X Ray Diffraction ◽  
X Ray ◽  
Enoyl Acp Reductase

Multi-drug resistant uropathogenic Escherichia coli and its treatment by Chinese medicine

2016 ◽  
Vol 23 (10) ◽  
pp. 763-769 ◽  
Author(s):  
Shi-wei Liu ◽  
Xiao-yang Xu ◽  
Jie Xu ◽  
Jiu-yun Yuan ◽  
Wei-kang Wu ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Chinese Medicine ◽  
Uropathogenic Escherichia Coli ◽  
Drug Resistant

Virtual screening of antibacterial compounds by similarity search of Enoyl-ACP reductase (FabI) inhibitors

2020 ◽  
Vol 12 (1) ◽  
pp. 51-68 ◽  
Author(s):  
Leonardo Rander Asse Junior ◽  
Thales Kronenberger ◽  
Mateus Sá Magalhães Serafim ◽  
Yamara Viana Sousa ◽  
Isabella Drumond Franco ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Virtual Screening ◽  
Therapeutic Potential ◽  
Structural Similarity ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Enoyl Acp Reductase ◽  
Potential Inhibitors ◽  
New Compounds ◽  
Development Methods

Aim: Antibiotic resistance is an alarming issue, as multidrug-resistant bacteria are growing worldwide, hence the decrease of therapeutic potential of available antibiotic arsenal. Among these bacteria, Staphylococcus aureus was pointed by the WHO in the pathogens list to be prioritized in drug development. Methods: We report the use of chemical similarity models for the virtual screening of new antibacterial with structural similarity to known inhibitors of FabI. The potential inhibitors were experimentally evaluated for antibacterial activity and membrane disrupting capabilities. Results & conclusion: These models led to the finding of four new compounds with antibacterial activity, one of which having antimicrobial activity already reported in the literature.

Docking, CoMFA, and CoMSIA analyses of phenoxy triazole derivatives as enoyl-ACP reductase inhibitors for Escherichia coli

2014 ◽  
Vol 23 (11) ◽  
pp. 4932-4955 ◽  
Author(s):  
Shrinivas D. Joshi ◽  
Devendra Kumar ◽  
Uttam A. More ◽  
Tejraj M. Aminabhavi
Keyword(s):  
Escherichia Coli ◽  
Triazole Derivatives ◽  
Reductase Inhibitors ◽  
Enoyl Acp Reductase

A study of the structure-activity relationship for diazaborine inhibition of Escherichia coli enoyl-ACP reductase

2001 ◽  
Vol 309 (1) ◽  
pp. 171-180 ◽  
Author(s):  
Colin W Levy ◽  
Clair Baldock ◽  
Alistair J Wallace ◽  
Sveta Sedelnikova ◽  
Russell C Viner ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Enoyl Acp Reductase
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