Cessation of ambulation results in a dramatic loss of trabecular bone density in boys with Duchenne muscular dystrophy (DMD)

Bone ◽  
2021 ◽  
pp. 116248
Author(s):  
N.J. Crabtree ◽  
H. Roper ◽  
N.J. Shaw
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Bone Density ◽  
Trabecular Bone ◽  
Trabecular Bone Density

Cessation of ambulation results in a dramatic loss of trabecular bone density in boys with Duchenne muscular dystrophy

2013 ◽  
Author(s):  
Crabtree Nicola ◽  
Bebbington Natalie ◽  
Roper Helen ◽  
McMurchie Heather ◽  
Shaw Nicholas
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Bone Density ◽  
Trabecular Bone ◽  
Trabecular Bone Density

Bone health in boys with Duchenne muscular dystrophy (DMD): the dichotomy between bone density and fracture

2017 ◽  
Author(s):  
Nicola Crabtree ◽  
Wolfgang Hogler ◽  
Helen Roper ◽  
Nicholas Shaw
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Bone Density ◽  
Bone Health

The effect of deer antler from East Kalimantan to increase trabecular bone density and calcium levels in serum on osteoporotic mice

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Retno Widyowati ◽  
Suciati Suciati ◽  
Dewi Melani Haryadi ◽  
Hsin-I Chang ◽  
IPG Ngurah Suryawan ◽  
...  
Keyword(s):  
Bone Density ◽  
Trabecular Bone ◽  
Aqueous Extract ◽  
Dependent Manner ◽  
Aqueous Extracts ◽  
Trabecular Bone Density ◽  
Male Mice ◽  
Deer Antler ◽  
East Kalimantan ◽  
Dose Dependent

Abstract Objectives Glucocorticoid-induced osteoporosis (dexamethasone) is a primary cause of secondary osteoporosis by the decreasing formation and increasing resorption activities. Previously, the in vitro study showed that 70% ethanol and aqueous extract of deer antler have increased alkaline phosphatase in osteoblast cell that known as marker of bone formation. The mind of this study is to analyze the effect of deer antlers in increasing the bone trabecular density of osteoporosis-induced male mice. Methods This study used a post-test control group design. A total of 54 healthy male mice were randomly divided to nine groups, i.e., healthy control, osteoporotic, positive control, 70% ethanol (4, 8, and 12 mg/kg BW), and aqueous extracts (4, 8, and 12 mg/kg BW) of deer antler groups. All of the interventions were given 1 mL of test sample for 4 weeks orally. The bone densities were determined using histomorphometry by Image J and Adobe Photoshop. The statistical data were performed using SPSS 23 and statistical significance was set at p<0.05. Results The results showed that alendronate group, 70% ethanol, and aqueous extract groups increased bone density and calcium levels in serum (p<0.05) compared to osteoporotic group in dose dependent manner. It indicated that 70% ethanol and aqueous extract of deer antler stimulating bone turnover and aqueous extract showed the highest. Conclusions Dexamethasone induction for 4 weeks caused osteoporotic mice and the administration of 70% ethanol and aqueous extracts of deer antler from East Kalimantan increased trabecular bone density and calcium levels in dose dependent manner.

scholarly journals POS1092 SUBCHONDRAL BONE NORMALIZATION AFTER KNEE JOINT DISTRACTION TREATMENT AS MEASURED WITH CT

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 825.2-826
Author(s):  
M. Jansen ◽  
A. Ooms ◽  
T. D. Turmezei ◽  
J. W. Mackay ◽  
S. Mastbergen ◽  
...  
Keyword(s):  
Bone Density ◽  
Trabecular Bone ◽  
Cortical Bone ◽  
Subchondral Bone ◽  
Trabecular Bone Density ◽  
Bone Thickness ◽  
Cortical Bone Thickness ◽  
Bone Changes ◽  
One Year ◽  
Shape Changes

Background:In addition to cartilage degeneration, knee osteoarthritis (OA) causes bone changes, including cortical bone thickening, subchondral bone density decrease, and bone shape changes as a result of widening and flattening condyles and osteophyte formation. Knee joint distraction (KJD) is a joint-preserving treatment for younger (<65 years) knee OA patients that has been shown to reverse OA cartilage degradation. On radiographs, KJD showed a decrease in subchondral bone density and an increase in osteophyte formation. However, these bone changes have never been evaluated with a 3D imaging technique.Objectives:To evaluate cortical bone thickness, subchondral trabecular bone density, and bone shape on CT scans before and one year after KJD treatment.Methods:19 KJD patients were included in an extended imaging protocol, undergoing a CT scan before and one year after treatment. Stradview v6.0 was used for semi-automatic tibia and femur segmentation from axial thin-slice (0.45mm) CT scans. Cortical bone thickness (mm) and trabecular bone density (Hounsfield units, HU) were measured with an automated algorithm. Osteophytes were excluded. Afterwards, wxRegSurf v18 was used for surface registration. Registration data was used for bone shape measurements. MATLAB R2020a and the SurfStat MATLAB package were used for data analysis and visualization. Two-tailed F-tests were used to calculate changes over time. Two separate linear regression models were used to show the influence of baseline Kellgren-Lawrence grade and sex on the changes over time. Statistical significance was calculated with statistical parametric mapping; a p-value <0.05 was considered statistically significant. Bone shape changes were explored visually using vertex by vertex displacements between baseline and follow-up. Patients were separated into two groups based on whether their most affected compartment (MAC) was medial or lateral. Only patients with axial CT scans at both time points available for analysis were included for evaluation.Results:3 Patients did not have complete CTs and in 1 patient the imaged femur was too short, leaving 16 patients for tibial analyses and 15 patients for femoral analyses. The MAC was predominantly the medial side (medial MAC n=14; lateral n=2). Before treatment, the MAC cortical bone was compared to the rest of the joint (Figure 1). One year after treatment, MAC cortical thickness decreased, although this decrease of up to approximately 0.25 mm was not statistically significant. The trabecular bone density was also higher before treatment in the MAC, and a decrease was seen throughout the entire joint, although statistically significant only for small areas on mostly the MAC where this decrease was up to approximately 80 HU (Figure 1). Female patients and patients with a higher Kellgren-Lawrence grade showed a somewhat larger decrease in cortical bone thickness. Trabecular density decreased less for patients with a higher Kellgren-Lawrence grade, and female patients showed a higher density decrease interiorly while male patients showed a higher decrease exteriorly. None of this was statistically significant. The central areas of both compartments showed an outward shape change, while the outer ring showed inward changes.Conclusion:MAC cortical bone thickness shows a partial decrease after KJD. Trabecular bone density decreased on both sides of the joint, likely as a direct result of the bicompartmental unloading. For both subchondral bone parameters, MAC values became more similar to the LAC, indicating (partial) subchondral bone normalization in the most affected parts of the joint. The bone shape changes may indicate a reversal of typical OA changes, although the inward difference that was seen on the outer edges may be a result of osteophyte-related changes that might have affected the bone segmentation. In conclusion, KJD treatment shows subchondral bone normalization in the first year after treatment, and longer follow-up might show whether these changes are a temporary result of joint unloading or indicate more prolonged bone changes.Disclosure of Interests:None declared.

Determinants of peak trabecular bone density in women: The role of androgens, estrogen, and exercise

2009 ◽  
Vol 3 (6) ◽  
pp. 673-680 ◽  
Author(s):  
James R. Buchanan ◽  
Cathleen Myers ◽  
Tom Lloyd ◽  
Paula Leuenberger ◽  
Laurence M. Demers
Keyword(s):  
Bone Density ◽  
Trabecular Bone ◽  
Trabecular Bone Density

scholarly journals Role of disc area and trabecular bone density on lumbar spinal column fracture risk curves under vertical impact

2018 ◽  
Vol 72 ◽  
pp. 90-98 ◽  
Author(s):  
Narayan Yoganandan ◽  
Jason Moore ◽  
Frank A. Pintar ◽  
Anjishnu Banerjee ◽  
Nicholas DeVogel ◽  
...  
Keyword(s):  
Bone Density ◽  
Fracture Risk ◽  
Trabecular Bone ◽  
Spinal Column ◽  
Trabecular Bone Density ◽  
Disc Area ◽  
Lumbar Spinal ◽  
Risk Curves ◽  
Vertical Impact

scholarly journals Mechanisms inducing low bone density in duchenne muscular dystrophy in mice and humans

2011 ◽  
Vol 26 (8) ◽  
pp. 1891-1903 ◽  
Author(s):  
Anna Rufo ◽  
Andrea Del Fattore ◽  
Mattia Capulli ◽  
Francesco Carvello ◽  
Loredana De Pasquale ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Bone Density ◽  
Low Bone Density

Distribution of Trabecular Bone Density in the Maxilla and Mandible

2019 ◽  
Vol 28 (4) ◽  
pp. 340-348 ◽  
Author(s):  
Danilo Alessio Di Stefano ◽  
Paolo Arosio ◽  
Stefano Pagnutti ◽  
Raffaele Vinci ◽  
Enrico Felice Gherlone
Keyword(s):  
Bone Density ◽  
Trabecular Bone ◽  
Trabecular Bone Density ◽  
Maxilla And Mandible

Exercise patterns and trabecular bone density in college women

1990 ◽  
Vol 5 (3) ◽  
pp. 245-250 ◽  
Author(s):  
Anne M. Davee ◽  
Clifford J. Rosen ◽  
Robert A. Adler
Keyword(s):  
Bone Density ◽  
Trabecular Bone ◽  
College Women ◽  
Trabecular Bone Density
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