Effect of proton pump inhibitors on bone mineral density: A systematic review and meta-analysis of observational studies

Background: Previous studies have suggested that osteoporosis and coronary heart disease have shared common risk factors. Some studies also suggested that low bone mineral density (BMD) also increased risk of peripheral vascular disease (PVD) or stroke. However, few longitudinal studies did not find significant association between these two conditions. We performed a systematic review and meta-analysis to explore association between low BMD and risk of PVD or stroke from prospective studies. Methods: We comprehensively searched the databases of PubMed/MEDLINE, EMBASE, and Cochrane Databases from their dates of inception to December 2015. The inclusion criteria were published prospective observational studies of PVD, stroke, BMD, osteoporosis, or fractures. Two authors independently assessed the quality of the articles and extracted the data. The primary outcome of interest was risk of new PVD or stroke events comparing between low BMD and normal BMD groups. Results: From 36 full-text articles, five observational studies involving 3,287 participants were included in the meta-analysis based on the random-effects model. There was increased risk of new peripheral vascular disease or stroke events in groups with low BMD compared with normal BMD controls with pooled hazard risk (HR) of 3.10 (95% CI: 1.32-7.23). In the subgroup analysis of fracture as a risk factor, there was no significant difference in risk of PVD or stroke in group with pooled HR of 1.17 (95% CI: 0.78-1.75). Conclusions: Low BMD is associated with increased risk of PVD and stroke from the meta-analysis of prospective observational studies. Clinicians should be aware of the close association between these two conditions. Early identification of PVD in patients with low BMD should be performed.

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Adherence to Mediterranean diet in relation to bone mineral density and risk of fracture: a systematic review and meta-analysis of observational studies

European Journal of Nutrition ◽

10.1007/s00394-017-1490-3 ◽

2017 ◽

Vol 57 (6) ◽

pp. 2147-2160 ◽

Cited By ~ 19

Author(s):

Hanieh Malmir ◽

Parvane Saneei ◽

Bagher Larijani ◽

Ahmad Esmaillzadeh

Keyword(s):

Bone Mineral Density ◽

Systematic Review ◽

Mediterranean Diet ◽

Bone Mineral ◽

Observational Studies ◽

Meta Analysis ◽

Mineral Density ◽

Risk Of Fracture

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Bone Mineral Density, Osteoporosis, and Fracture Risk in Adult Patients with Psoriasis or Psoriatic Arthritis: A Systematic Review and Meta-Analysis of Observational Studies

Journal of Clinical Medicine ◽

10.3390/jcm9113712 ◽

2020 ◽

Vol 9 (11) ◽

pp. 3712

Author(s):

Tai-Li Chen ◽

Jing-Wun Lu ◽

Yu-Wen Huang ◽

Jen-Hung Wang ◽

Kuei-Ying Su

Keyword(s):

Bone Mineral Density ◽

Systematic Review ◽

Psoriatic Arthritis ◽

Bone Mineral ◽

Observational Studies ◽

Meta Analysis ◽

Mineral Density ◽

Psoriatic Disease ◽

Increased Risk ◽

Significant Difference

Introduction: Awareness of psoriasis-related comorbidities has been established in the current guidelines; however, evidence regarding the association of bone density or bone fragility with psoriatic disease remains inconclusive. Methods: We conducted a systematic review and meta-analysis to assess bone mineral density and the risk of osteoporosis and fractures in patients with psoriatic disease, including those with cutaneous psoriasis and psoriatic arthritis. We searched electronic databases for published observational studies. A meta-analysis was performed using the random-effect model. Pooled estimates and their confidence intervals (CIs) were calculated. Small-study effects were examined using the Doi plot and Luis Furuya–Kanamori index. Results: The analysis of the standardized mean difference in the absolute value of bone mineral density at different measuring sites (lumbar spine, femoral neck, and total hip) revealed no significant difference between patients with psoriatic disease and non-psoriatic controls. The pooled results of the adjusted odds ratios (ORs) demonstrated no increased risk of osteoporosis in patients with psoriatic disease. Notably, patients with psoriatic disease had a higher OR of developing bone fractures (adjusted OR: 1.09; 95% CI: 1.06 to 1.12; I2: 0%). Conclusion: Patients with psoriatic disease may be more likely to develop fractures compared with non-psoriatic controls. This higher risk for fracture may not necessarily be associated with lower bone mineral density nor a higher risk for osteoporosis.

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Effects of Recreational Small-Sided Soccer Games on Bone Mineral Density in Untrained Adults: A Systematic Review and Meta-Analysis

Healthcare ◽

10.3390/healthcare9040457 ◽

2021 ◽

Vol 9 (4) ◽

pp. 457

Author(s):

Filipe Manuel Clemente ◽

Rodrigo Ramirez-Campillo ◽

Hugo Sarmento ◽

Daniel Castillo ◽

Javier Raya-González ◽

...

Keyword(s):

Bone Mineral Density ◽

Systematic Review ◽

Active Control ◽

Bone Mineral ◽

Meta Analysis ◽

Adult Population ◽

Noncommunicable Disease ◽

Lower Limbs ◽

Mineral Density ◽

Control Groups

This systematic review with meta-analysis was conducted to assess the effects of small-sided games (SSG)-based training programs on bone mineral density (BMD) in untrained adults. The data sources utilized were Cochrane, Embase, Medline (PubMed), Scopus, SPORTDiscus, and Web of Science. The study eligibility criteria were: (i) untrained adults (>18 years old) of any sex, with or without a noncommunicable disease; (ii) SSG-based programs with a minimum duration of four weeks and no restrictions regarding frequency (number of sessions per week); (iii) passive or active control groups; (iv) pre-post values of BMD; (v) only randomized controlled trials; and (vi) only original and full-text studies written in English. The database search initially yielded 374 titles. From those, nine articles were eligible for the systematic review and meta-analysis. The age of included population varied from a minimum of 20 and a maximum of 71 years old. Non-significant differences between SSG and passive and active control groups on total BMD (ES = 0.14; p = 0.405 and ES = 0.28; p = 0.05, respectively). Meanwhile, significant differences in favor of SSGs vs. passive and control groups were detected, evidencing an improvement of BMD in lower limbs of the adult population for both sexes (ES = 0.26; p = 0.05 and ES = 0.28; p = 0.156, respectively). As conclusions, SSGs can be used as a non-pharmacological alternative to increase the BMD in the lower limbs despite having no significant impact on total body BMD. Careful generalization should be done of the level of heterogeneity.

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