Anti-inflammatory activity of bavachinin against various forms of inflammatory disorders including asthmatic inflammation: Importance of natural medicine in the current scientific research

Inflammation in peripheral tissues should benefit from a novel focus on descending neuroimmunomodulatory anti-inflammatory influences stemming from CNS receptors for the peptide α-MSH. Because activation of glial and peripheral cell receptors modulates inflammatory activity, α-MSH peptides may aid treatment of a variety of CNS and peripheral inflammatory disorders. Activation of melanocortin receptors should thus promote control of inflammatory diseases.

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Use of clays using ursolic acid with anti-inflammatory activity

MRS Proceedings ◽

10.1557/opl.2011.469 ◽

2011 ◽

Vol 1301 ◽

Author(s):

M.L. Domínguez-Patiño ◽

M. Chávez-Castillo ◽

A. Rodríguez-Martínez

Keyword(s):

Ursolic Acid ◽

Cellular Systems ◽

The Body ◽

Inflammatory Activity ◽

Human Beings ◽

New Materials ◽

Natural Medicine ◽

Anti Inflammatory ◽

Pharmacologically Active

ABSTRACTToday the company seeks alternative natural medicine that are compatible with the body, which does not produce side effects and hang time are easily accessible and cost of those who currently have. The concern of researchers and specialists in the development of new materials is to seek, to experiment and create products that can be useful and compatible with human beings so as to obtain a curative effect without a side effect originates.The development of pharmacologically active materials has increased in recent years. People lack access to most drugs and is therefore a need for more rapid and less expensive than current, which can be applied to cellular systems in vitro, in order to evaluate the biocompatibility of new materials. The current study seeks to experiment in a new line of research that helps health care and have a better quality of life.The excipients in the drug are auxiliary substances that help the active ingredient is the one with the therapeutic action, can be formulated in an effective and pleasant for the patient. It is one or more substances that are incorporated into the product to facilitate its preparation, maintenance or administration. We therefore tested clay known as bentonite to serve as a vehicle for transport of an active substance (ursolic acid) [1] and some scientific studies have shown that it possesses anti-inflammatory, antibacterial, antifungal and highly cytotoxic capacity. Both materials were mixed to generate a new biomaterial that has anti-inflammatory activity. Evaluation of this model was under the inhibition of edema produced by 13-acetate-12-ortho-tetradecanoylphorbol (TPA) in mouse ear.

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Lipophilic stinging nettle extracts possess potent anti-inflammatory activity, are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders

Phytomedicine ◽

10.1016/j.phymed.2012.09.016 ◽

2013 ◽

Vol 20 (2) ◽

pp. 143-147 ◽

Cited By ~ 20

Author(s):

Tyler A. Johnson ◽

Johann Sohn ◽

Wayne D. Inman ◽

Leonard F. Bjeldanes ◽

Keith Rayburn

Keyword(s):

Inflammatory Activity ◽

Stinging Nettle ◽

Inflammatory Disorders ◽

Anti Inflammatory

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Chemical, Cytotoxic, and Anti-Inflammatory Assessment of Honey Bee Venom from Apis mellifera intermissa

Antibiotics ◽

10.3390/antibiotics10121514 ◽

2021 ◽

Vol 10 (12) ◽

pp. 1514

Author(s):

Iouraouine El Mehdi ◽

Soraia I. Falcão ◽

Mustapha Harandou ◽

Saïd Boujraf ◽

Ricardo C. Calhelha ◽

...

Keyword(s):

Apis Mellifera ◽

Honey Bee ◽

Bee Venom ◽

Inflammatory Activity ◽

Breast Adenocarcinoma ◽

Compositional Variation ◽

Cell Lung Carcinoma ◽

Natural Medicine ◽

Apis Mellifera Intermissa ◽

Anti Inflammatory

The venom from Apis mellifera intermissa, the main honey bee prevailing in Morocco, has been scarcely studied, despite its known potential for pharmacological applications. In the present work, we investigated the composition, the anti-inflammatory activity, and the venom’s cytotoxic properties from fifteen honey bee venom (HBV) samples collected in three regions: northeast, central, and southern Morocco. The chemical assessment of honey bee venom was performed using LC-DAD/ESI/MSn, NIR spectroscopy and AAS spectroscopy. The antiproliferative effect was evaluated using human tumor cell lines, including breast adenocarcinoma, non-small cell lung carcinoma, cervical carcinoma, hepatocellular carcinoma, and malignant melanoma. Likewise, we assessed the anti-inflammatory activity using the murine macrophage cell line. The study provides information on the honey bee venom subspecies’ main components, such as melittin, apamin, and phospholipase A2, with compositional variation depending on the region of collection. Contents of toxic elements such as cadmium, chromium, and plumb were detected at a concentration below 5 ppm, which can be regarded as safe for pharmaceutical use. The data presented contribute to the first study in HBV from Apis mellifera intermissa and highlight the remarkable antiproliferative and anti-inflammatory effects of HBV, suggesting it to be a candidate natural medicine to explore.

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