scholarly journals Curvature and Specific Lipid-Protein Interactions Modulate Activity of Rhodopsin

2009 ◽  
Vol 96 (3) ◽  
pp. 378a
Author(s):  
Olivier Soubias ◽  
Shui-Lin Niu ◽  
Drake C. Mitchell ◽  
Klaus Gawrisch
Keyword(s):  
Protein Interactions ◽  
Lipid Protein Interactions ◽  
Specific Lipid

Lipid–Protein Interactions in Plasma Membrane Organization and Function

2022 ◽  
Vol 51 (1) ◽  
Author(s):  
Taras Sych ◽  
Kandice R. Levental ◽  
Erdinc Sezgin
Keyword(s):  
Plasma Membrane ◽  
Protein Interactions ◽  
Collective Behavior ◽  
Protein Function ◽  
Lipid Binding ◽  
Publication Date ◽  
Membrane Organization ◽  
Lipid Protein Interactions ◽  
And Function ◽  
Specific Lipid

Lipid–protein interactions in cells are involved in various biological processes, including metabolism, trafficking, signaling, host–pathogen interactions, and transmembrane transport. At the plasma membrane, lipid–protein interactions play major roles in membrane organization and function. Several membrane proteins have motifs for specific lipid binding, which modulate protein conformation and consequent function. In addition to such specific lipid–protein interactions, protein function can be regulated by the dynamic, collective behavior of lipids in membranes. Emerging analytical, biochemical, and computational technologies allow us to study the influence of specific lipid–protein interactions, as well as the collective behavior of membranes on protein function. In this article, we review the recent literature on lipid–protein interactions with a specific focus on the current state-of-the-art technologies that enable novel insights into these interactions. Expected final online publication date for the Annual Review of Biophysics, Volume 51 is May 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals Signal Transduction in the Visual Cascade Involves Specific Lipid-Protein Interactions

2003 ◽  
Vol 278 (25) ◽  
pp. 22853-22860 ◽  
Author(s):  
Elke Hessel ◽  
Martin Heck ◽  
Peter Müller ◽  
Andreas Herrmann ◽  
Klaus Peter Hofmann
Keyword(s):  
Signal Transduction ◽  
Protein Interactions ◽  
Lipid Protein Interactions ◽  
Specific Lipid

scholarly journals Lipid Microdomains in Cell Nucleus

2008 ◽  
Vol 19 (12) ◽  
pp. 5289-5295 ◽  
Author(s):  
Giacomo Cascianelli ◽  
Maristella Villani ◽  
Marcello Tosti ◽  
Francesca Marini ◽  
Elisa Bartoccini ◽  
...  
Keyword(s):  
Protein Interactions ◽  
Lipid Composition ◽  
Protein Complexes ◽  
Membrane Microdomains ◽  
Cellular Functions ◽  
Transcription Process ◽  
Lipid Protein Interactions ◽  
First Time ◽  
Specific Lipid

It is known that nuclear lipids play a role in proliferation, differentiation, and apoptotic process. Cellular nuclei contain high levels of phosphatidylcholine and sphingomyelin, which are partially linked with cholesterol and proteins to form lipid–protein complexes. These lipids are also associated with transcription factors and newly synthesized RNA but, up to date, their organization is still unknown. The aim of the present work was to study if these specific lipid–protein interactions could be nuclear membrane microdomains and to evaluate their possible role. The results obtained demonstrate for the first time the existence of nuclear microdomains characterized by a specific lipid composition similar to that of intranuclear lipid–protein complexes previously described. Nuclear microdomain lipid composition changes during cell proliferation when the content of newly synthesized RNA increases. Because previous data show a correlation between nuclear lipids and transcription process, the role of nuclear microdomains in cellular functions is discussed.

scholarly journals Molecular interactions of the M and E integral membrane proteins of SARS-CoV-2

2021 ◽  
Author(s):  
Viviana Monje-Galvan ◽  
Gregory A Voth
Keyword(s):  
Membrane Proteins ◽  
Molecular Interactions ◽  
Protein Interactions ◽  
Integral Membrane Proteins ◽  
Cellular Processes ◽  
Lipid Protein Interactions ◽  
Specific Lipid

Specific lipid-protein interactions are key for cellular processes, and even more so for the replication of pathogens. The COVID-19 pandemic has drastically changed our lives and cause the death of...

scholarly journals Lipids as cofactors in protein folding: Stereo-specific lipid-protein interactions are required to form HAMLET (human α-lactalbumin made lethal to tumor cells)

2003 ◽  
Vol 12 (12) ◽  
pp. 2805-2814 ◽  
Author(s):  
Malin Svensson ◽  
Ann-Kristin Mossberg ◽  
Jenny Pettersson ◽  
Sara Linse ◽  
Catharina Svanborg
Keyword(s):  
Protein Folding ◽  
Tumor Cells ◽  
Protein Interactions ◽  
Lipid Protein Interactions ◽  
Specific Lipid

scholarly journals Lipid fingerprints are similar between SLC6 transporters in the neuronal membrane

2021 ◽  
Author(s):  
Katie A. Wilson ◽  
Lily Wang ◽  
Yie Chang Lin ◽  
Megan L. O’Mara
Keyword(s):  
Protein Interactions ◽  
Neuronal Membrane ◽  
List Type ◽  
Membrane Composition ◽  
Biophysical Properties ◽  
Complex Membrane ◽  
Lipid Environment ◽  
Lipid Protein Interactions ◽  
Dynamics Simulations ◽  
Specific Lipid

ABSTRACTWe use molecular dynamics simulations to characterise the local lipid annulus, or “fingerprint”, of three SLC6 transporters (dDAT, hSERT, and GlyT2) embedded into a complex neuronal membrane. New membrane analysis tools were created to improve leaflet detection and leaflet-dependent properties. Overall, lipid fingerprints are comprised of similar lipids when grouped by headgroup or tail saturation. The enrichment and depletion of specific lipids, including sites of cholesterol contacts, varies between transporters. The subtle differences in lipid fingerprints results in varying membrane biophysical properties near the transporter. Through comparisons to previous literature, we highlight that the lipid-fingerprint in complex membranes is highly dependent on membrane composition. Furthermore, through embedding these transporters in a simplified model membrane, we show that the simplified membrane is not able to capture the biophysical properties of the complex membrane. Our results further characterise how the presence and identity of membrane proteins affects the complex interplay of lipid-protein interactions, including the local lipid environment and membrane biophysical properties.HIGHLIGHTSLipid fingerprints are comprised of similar lipid classesSites of specific lipid contacts, including CHOL, varies between transportersChanges in lipid annulus result in variable local membrane biophysical propertiesMembrane composition, including that of complex membranes, affects lipid annulusGRAPHICAL ABSTRACT

scholarly journals General and specific lipid–protein interactions in Na,K-ATPase

2015 ◽  
Vol 1848 (9) ◽  
pp. 1729-1743 ◽  
Author(s):  
F. Cornelius ◽  
M. Habeck ◽  
R. Kanai ◽  
C. Toyoshima ◽  
S.J.D. Karlish
Keyword(s):  
Protein Interactions ◽  
Lipid Protein Interactions ◽  
Specific Lipid
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