scholarly journals Cell Volume in Brain Pathologies: Anions-Controlled Neural and Glial Swelling in Spreading Depolarization and Increased Neuronal Susceptibility to Ischemic Injury due to Large Extracellular Space

2016 ◽  
Vol 110 (3) ◽  
pp. 632a
Author(s):  
Niklas Hubel
Keyword(s):  
Cell Volume ◽  
Extracellular Space ◽  
Ischemic Injury ◽  
Spreading Depolarization

Potassium homeostasis

2015 ◽  
Author(s):  
Alain Doucet ◽  
Gilles Crambert
Keyword(s):  
Electrical Properties ◽  
Cell Volume ◽  
Extracellular Space ◽  
Resting Potential ◽  
Excitable Cells ◽  
Intracellular Compartment ◽  
Potassium Homeostasis ◽  
Membrane Resting Potential ◽  
Intracellular Osmolarity ◽  
Internal Balance

The equilibrium between the concentration of K+ in the extracellular space (low) and the intracellular compartment (high) is crucial for maintaining the electrical properties of excitable and non-excitable cells, because it determines the membrane resting potential. The high intracellular concentration of K+ (120–140 mmol/L) also contributes to the intracellular osmolarity, a determinant of cell volume. It is therefore crucial to finely tune both extracellular and intracellular K+ concentrations. There is a coordinated regulation between processes/mechanisms that store/release K+ from internal stores (internal balance) and those that retain/excrete K+ (external balance).

scholarly journals Effect of reperfusion late in the phase of reversible ischemic injury. Changes in cell volume, electrolytes, metabolites, and ultrastructure.

1985 ◽  
Vol 56 (2) ◽  
pp. 262-278 ◽  
Author(s):  
R B Jennings ◽  
J Schaper ◽  
M L Hill ◽  
C Steenbergen ◽  
K A Reimer
Keyword(s):  
Cell Volume ◽  
Ischemic Injury

A simple method for volumetric measurements in isolated cardiac muscle

1979 ◽  
Vol 236 (3) ◽  
pp. H519-H524
Author(s):  
S. R. Houser ◽  
A. R. Freeman
Keyword(s):  
Cardiac Muscle ◽  
Cell Volume ◽  
Extracellular Space ◽  
Voltage Drop ◽  
Electrical Current ◽  
Experimental Chamber ◽  
Papillary Muscles ◽  
Simple Method ◽  
Disease States ◽  
Direct Electrical Current

A new method for the study of extracellular space and cell volume of cardiac muscle is described. Canine cardiac Purkinje strands and cat papillary muscles were placed within a fluid-filled aperture connecting two sides of an experimental chamber. Direct electrical current was passed through the hole, and changes in the voltage drop across it were correlated with Purkinje strand extracellular space and cell volume. The results of experiments on 21 Purkinje strands and 4 papillary muscles yielded an extracellular space of 51 +/- 2.1% (SEM) and 23.3 +/- 2.1%, respectively. When strands were superfused with hyper- (600 mosM) and hyposmotic (150 mosM) solutions, the preparations were found to attain new steady-state volumes that were 75 +/- 3.1% and 121 +/- 9% of control, respectively. This method can be used for volumetric studies in numerous cardiac muscle preparations and should be applicable to the study of volume abnormalities associated with certain disease states.

Scanning electron microscopic study of collagen fibrillogenesis and extracellular compartmentalization in the chick embryo tendon

1986 ◽  
Vol 44 ◽  
pp. 208-209
Author(s):  
Grace C.H. Yang
Keyword(s):  
Chick Embryo ◽  
Extracellular Space ◽  
Fibroblast Cell ◽  
Collagen Fibrils ◽  
Electron Microscopic ◽  
Voltage Electron ◽  
Scanning Electron Microscopic Study ◽  
Microscopic Studies ◽  
And Function

The size and organization of collagen fibrils in the extracellular matrix is an important determinant of tissue structure and function. The synthesis and deposition of collagen involves multiple steps which begin within the cell and continue in the extracellular space. High-voltage electron microscopic studies of the chick embryo cornea and tendon suggested that the extracellular space is compartmentalized by the fibroblasts for the regulation of collagen fibril, bundle, and tissue specific macroaggregate formation. The purpose of this study is to gather direct evidence regarding the association of the fibroblast cell surface with newly formed collagen fibrils, and to define the role of the fibroblast in the control and the precise positioning of collagen fibrils, bundles, and macroaggregates during chick tendon development.

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