Red blood cell shape transitions and dynamics in time-dependent capillary flows

2021 ◽  
Author(s):  
Steffen M. Recktenwald ◽  
Katharina Graessel ◽  
Felix M. Maurer ◽  
Thomas John ◽  
Stephan Gekle ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Shape ◽  
Time Dependent ◽  
Capillary Flows ◽  
Shape Transitions

Red Blood Cell Shape

2020 ◽  
pp. 401-421
Author(s):  
Brian S. Bull ◽  
Douglas Brailsford
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Shape

scholarly journals Time-Dependent Indirect Antioxidative Effects of Oat Beta-Glucans on Peripheral Blood Parameters in the Animal Model of Colon Inflammation

Antioxidants ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 375 ◽  
Author(s):  
Łukasz Kopiasz ◽  
Katarzyna Dziendzikowska ◽  
Małgorzata Gajewska ◽  
Jacek Wilczak ◽  
Joanna Harasym ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Peripheral Blood ◽  
Molar Mass ◽  
Time Dependent ◽  
Mean Corpuscular Hemoglobin ◽  
Beta Glucan ◽  
High Molar Mass ◽  
Colon Inflammation ◽  
Beta Glucans

Background: Oat beta-glucans are polysaccharides, belonging to soluble fiber fraction, that show a wide spectrum of biological activity. The aim of this study was to evaluate the time-dependent antioxidative effect of chemically pure oat beta-glucan fractions, characterized by different molar mass, which were fed to animals with early stage of 2,4,6-trinitrobenzene sulfonic acid (TNBS) - induced colitis. Methods: The study was conducted on 150 adult male Sprague Dawley rats assigned to two groups—healthy control (H) and colitis (C) with colon inflammation induced by per rectum administration of TNBS. The animals from both groups were divided into 3 nutritional subgroups, receiving for 3, 7 or 21 days AIN-93M feed without beta-glucan (βG−) or with 1% (w/w) low molar mass oat beta-glucan (βGl+) or 1% (w/w) high molar mass oat beta-glucan (βGh+). After 3, 7 and 21 days, the animals were euthanized, peripheral blood was collected from the heart for further analysis. Results: The results of analyses performed on blood samples showed small changes in lymphocytes count and red blood cell parameters such as the number of red blood cell, mean corpuscular hemoglobin concentration and mean corpuscular volume (RBC, MCHC, MCV respectively) as well as normalization of antioxidant potential accompanying moderate inflammatory state of colon mucosa and submucosa. Conclusion: Oat beta-glucans exert an indirect antioxidant effect in animals with TNBS-induced colitis, with greater effectiveness in removing systemic effects of colon inflammation found for low molar mass oat beta-glucan.

scholarly journals Shape matters: the effect of red blood cell shape on perfusion of an artificial microvascular network

Transfusion ◽  
2015 ◽  
Vol 56 (4) ◽  
pp. 844-851 ◽  
Author(s):  
Nathaniel Z. Piety ◽  
Walter H. Reinhart ◽  
Patrick H. Pourreau ◽  
Rajaa Abidi ◽  
Sergey S. Shevkoplyas
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Shape ◽  
Microvascular Network

AN EFFICIENT IDENTIFICATION OF RED BLOOD CELL EQUILIBRIUM SHAPE USING NEURAL NETWORKS

2021 ◽  
Vol 9 (2) ◽  
pp. 39-56
Author(s):  
Houda Fahim ◽  
◽  
Olivier Sawadogo ◽  
Nour Alaa ◽  
Mohammed Guedda ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Shape ◽  
Applied Mathematics ◽  
Equilibrium Shape ◽  
Shape Identification ◽  
Curvature Energy ◽  
Neural Network Algorithm ◽  
New Formulation ◽  
Additional Constraints

This work of applied mathematics with interfaces in bio-physics focuses on the shape identification and numerical modelisation of a single red blood cell shape. The purpose of this work is to provide a quantitative method for interpreting experimental observations of the red blood cell shape under microscopy. In this paper we give a new formulation based on classical theory of geometric shape minimization which assumes that the curvature energy with additional constraints controls the shape of the red blood cell. To minimize this energy under volume and area constraints, we propose a new hybrid algorithm which combines Particle Swarm Optimization (PSO), Gravitational Search (GSA) and Neural Network Algorithm (NNA). The results obtained using this new algorithm agree well with the experimental results given by Evans et al. (8) especially for sphered and biconcave shapes.

scholarly journals Red blood cell (RBC) aggregation and its influence on non-Newtonian nature of blood in microvasculature

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Chitra Murali ◽  
Perumal Nithiarasu
Keyword(s):  
Blood Flow ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Aggregation ◽  
Time Dependent ◽  
Shear Rates ◽  
Red Blood Cell Aggregation ◽  
Significant Difference ◽  
Rbc Aggregation ◽  
Rouleaux Formation

AbstractA robust computational model is proposed to investigate the non-Newtonian nature of blood flow due to rouleaux formation in microvasculature. The model consists of appropriate forces responsible for red blood cell (RBC) aggregation in the microvasculature, tracking of RBCs, and coupling between plasma flow and RBCs. The RBC aggregation results have been compared against the available data. The importance of different hydrodynamic forces on red blood cell aggregation has been delineated by comparing the time dependent path of the RBCs. The rheological changes to the blood flow have been investigated under different shear rates and hematocrit values and quantified with and without RBC aggregation. The results obtained in terms of wall shear stress (WSS) and blood viscosity indicate a significant difference between Newtonian and powerlaw fluid assumptions.

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