The problem of studying the prеvalencе of allergic diseases of the eye and the search for new approaches and effective means to correct this condition does not lose its relevance. The presented data on the state of profound biochemical studies of the tear film in allergic conditions justify the expediency of the use of eye drops of a new generation. As a result of experimental studies on the effect on the lipid layer ectoine was discovered the mechanism of its therapeutic action. This paper presents compelling evidence that new eye drops based on natural molecules ectoine which are able to restore and maintain the functional state of the lipid layer of the tear film in the pharmacotherapy of аllergic diseases of anterior surface of the eye. The analyzes of multiple experimental data revealed the clear evidence of mechanisms of action on the eye and the first clinical experience with a new pharmacological agent testifies to its strong anti-inflammatory and regenerative effect due to the stabilization of the lipid layer of the tear film and the protection of the front surface of the eye tissue from the hyperosmolarity. It was confirmed by the subjective and objective reducing eye irritation and dryness in reducing itching and burning from the conjunctiva, to improve the moisture level of the surface of the eye, to reduce discomfort of the eyes. The drug can be used in children older than 2 years and adults, when wearing contact lenses, ophthalmic surgery and after an eye injury. Based on this, it can be conclude that the appearance in the arsenal of new-generation antiallergic eye drops (EYE-t) with sufficient efficacy and safety profile can be regarded as a promising alternative approach to the treatment of allergic and inflammatory eye diseases.
The Properties and Role of O-Acyl-ω-hydroxy Fatty Acids and Type I-St and Type II Diesters in the Tear Film Lipid Layer Revealed by a Combined Chemistry and Biophysics Approach
