Chronic, systemic treatment with a metabotropic glutamate receptor 5 antagonist in 6-hydroxydopamine partially lesioned rats reverses abnormal firing of dopaminergic neurons

Brain Research ◽

10.1016/j.brainres.2009.06.040 ◽

2009 ◽

Vol 1286 ◽

pp. 192-200 ◽

Author(s):

Li Chen ◽

Qiao Jun Zhang ◽

Jian Liu ◽

Shuang Wang ◽

Umar Ali ◽

...

Keyword(s):

Glutamate Receptor ◽

Dopaminergic Neurons ◽

Metabotropic Glutamate Receptor ◽

Systemic Treatment ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

6 Hydroxydopamine

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Blockade of metabotropic glutamate receptor 5 attenuates axonal degeneration in 6-hydroxydopamine-induced model of Parkinson's disease

Molecular and Cellular Neuroscience ◽

10.1016/j.mcn.2020.103572 ◽

2021 ◽

Vol 110 ◽

pp. 103572

Author(s):

Jian-Nan Zhang ◽

Yan-Lin Huang ◽

Hui-Min Yang ◽

Yuan Wang ◽

Li Gu ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Glutamate Receptor ◽

Axonal Degeneration ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

6 Hydroxydopamine

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Chronic, systemic treatment with a metabotropic glutamate receptor 5 antagonist produces anxiolytic-like effects and reverses abnormal firing activity of projection neurons in the basolateral nucleus of the amygdala in rats with bilateral 6-OHDA lesions

Brain Research Bulletin ◽

10.1016/j.brainresbull.2011.01.005 ◽

2011 ◽

Vol 84 (3) ◽

pp. 215-223 ◽

Author(s):

Li Chen ◽

Jian Liu ◽

Umar Ali ◽

Zhen Hua Gui ◽

Chen Hou ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Systemic Treatment ◽

Projection Neurons ◽

Firing Activity ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Basolateral Nucleus

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Changes in the Gene Expression of GABAA Receptor α1 and α2 Subunits and Metabotropic Glutamate Receptor 5 in the Basal Ganglia of the Rats with Unilateral 6-Hydroxydopamine Lesion and Embryonic Mesencephalic Grafts

Experimental Neurology ◽

10.1006/exnr.2000.7590 ◽

2001 ◽

Vol 168 (2) ◽

pp. 231-241 ◽

Author(s):

Tzong-Shiue Yu ◽

Shwun-De Wang ◽

Jiang-Chuan Liu ◽

Hsiang-Shu Yin

Keyword(s):

Gene Expression ◽

Basal Ganglia ◽

Gabaa Receptor ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

6 Hydroxydopamine

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Cystic fibrosis transmembrane conductance regulator-associated ligand protects dopaminergic neurons by differentially regulating metabotropic glutamate receptor 5 in the progression of neurotoxin 6-hydroxydopamine-induced Parkinson's disease model

NeuroToxicology ◽

10.1016/j.neuro.2021.02.003 ◽

2021 ◽

Vol 84 ◽

pp. 14-29

Author(s):

Yuan Wang ◽

Li Gu ◽

Hui Min Yang ◽

Hong Zhang

Keyword(s):

Cystic Fibrosis ◽

Dopaminergic Neurons ◽

Metabotropic Glutamate Receptor ◽

Disease Model ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

6 Hydroxydopamine ◽

Cystic Fibrosis Transmembrane

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The Effects of MPEP, a Selective Metabotropic Glutamate Receptor 5 Antagonist, on Conditioned Taste Aversion in Rats

PsycEXTRA Dataset ◽

10.1037/e413812005-369 ◽

2002 ◽

Author(s):

Todd R. Schachtman ◽

Carla Bills ◽

Rodica Ghinescu ◽

Kevin Murch ◽

Agnes Simonyi

Keyword(s):

Taste Aversion ◽

Glutamate Receptor ◽

Conditioned Taste Aversion ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Faculty Opinions recommendation of Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718499023.793498248 ◽

2014 ◽

Author(s):

Roland Seifert

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Transmembrane Domain ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

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Faculty Opinions recommendation of Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.732704940.793543297 ◽

2018 ◽

Author(s):

Dario Doller

Keyword(s):

G Protein ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

G Protein Coupled Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

X Ray ◽

Metabotropic Glutamate ◽

G Protein Coupled

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Downregulation of metabotropic glutamate receptor 5 alleviates central sensitization by activating autophagy via inhibiting mTOR pathway in a rat model of chronic migraine

Neuroscience Letters ◽

10.1016/j.neulet.2020.135552 ◽

2021 ◽

Vol 743 ◽

pp. 135552

Author(s):

Yingying Niu ◽

Xiaoxu Zeng ◽

Guangcheng Qin ◽

Dunke Zhang ◽

Jiying Zhou ◽

...

Keyword(s):

Chronic Migraine ◽

Glutamate Receptor ◽

Rat Model ◽

Central Sensitization ◽

Metabotropic Glutamate Receptor ◽

Mtor Pathway ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory

Neuroscience ◽

10.1016/j.neuroscience.2006.06.043 ◽

2006 ◽

Vol 142 (3) ◽

pp. 691-702 ◽

Author(s):

D. Balschun ◽

W. Zuschratter ◽

W. Wetzel

Keyword(s):

Spatial Memory ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Opposite regulation of metabotropic glutamate receptor 3 and metabotropic glutamate receptor 5 by inflammatory stimuli in cultured microglia and astrocytes

Neuroscience ◽

10.1016/j.neuroscience.2011.12.044 ◽

2012 ◽

Vol 205 ◽

pp. 29-38 ◽

Author(s):

J.V. Berger ◽

A.O. Dumont ◽

M.C. Focant ◽

M. Vergouts ◽

A. Sternotte ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Metabotropic Glutamate Receptor 3 ◽

Inflammatory Stimuli

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