Epidermal growth factor receptor (EGFR) gene copy number in colorectal adenoma-carcinoma progression

2012 ◽  
Vol 205 (12) ◽  
pp. 630-635 ◽  
Author(s):  
Marcella Flora ◽  
Simonetta Piana ◽  
Cristina Bassano ◽  
Alessandra Bisagni ◽  
Loredana De Marco ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Colorectal Adenoma ◽  
Copy Number ◽  
Gene Copy Number ◽  
Growth Factor Receptor ◽  
Gene Copy ◽  
Egfr Gene ◽  
Epidermal Growth

scholarly journals Epidermal growth factor receptor in breast carcinoma: association between gene copy number and mutations

2011 ◽  
Vol 6 (1) ◽  
pp. 118 ◽  
Author(s):  
Ning Lv ◽  
Xiaoming Xie ◽  
Qidong Ge ◽  
Suxia Lin ◽  
Xi Wang ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Breast Carcinoma ◽  
Epidermal Growth Factor ◽  
Copy Number ◽  
Gene Copy Number ◽  
Growth Factor Receptor ◽  
Gene Copy ◽  
Epidermal Growth

Relationship between epidermal growth factor receptor gene copy number and protein expression in oral cavity squamous cell carcinoma

Oral Oncology ◽  
2012 ◽  
Vol 48 (1) ◽  
pp. 67-72 ◽  
Author(s):  
Shiang-Fu Huang ◽  
Sou-De Cheng ◽  
Huei-Tzu Chien ◽  
Chun-Ta Liao ◽  
I-How Chen ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Copy Number ◽  
Receptor Gene ◽  
Gene Copy Number ◽  
Growth Factor Receptor ◽  
Gene Copy ◽  
Epidermal Growth

Prognostic value of epidermal growth factor receptor gene amplification in surgically resected non-adenocarcinoma lung cancer patients.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e18553-e18553
Author(s):  
Yaewon Yang ◽  
Hyun Chang ◽  
Jong-Seok Lee ◽  
YuJung Kim ◽  
Sang-hoon Jheon ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Overall Survival ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Copy Number ◽  
Gene Copy Number ◽  
Growth Factor Receptor ◽  
Gene Copy ◽  
Egfr Gene ◽  
Epidermal Growth

e18553 Background: The purpose of this study is to investigate the prognostic role of genomoic gain and expression for epidermal growth factor receptor (EGFR) gene in surgically resected non-adenocarcinoma of non-small-cell lung cancer (NA-NSCLC). Methods: This retrospective study included 115 NA-NSCLC consecutive patients with available tumor tissue and survival data, median follow up period of 6.4 years. EGFR gene copy number and protein expression was evaluated using by fluorescent in situ hybridization (FISH) and immunohistochemistry (IHC) in tissue microarray sections, respectively. Results: Among 115 patients, 99 patients (86.1 %) were with squamous cell carcinoma histology. EGFR gene amplification and high polysomy (EGFR FISH+) were observed in 57 (49.6%) and 45 (39.1%) patients, respectively. Patients with EGFR FISH+ had significantly shorter overall survival [median, 41 months vs. not reached (>70 months), P = 0.011]. Multivariable model confirmed that patients with EGFR FISH+ had a significantly greater risk of death than those with EGFR FISH-negative after adjusting pathologic staging, presence of pleural invasion, venous invasion and adjuvant chemotherapy (hazard ratio = 2.11, 95% confidence interval 1.23-3.61, P = 0.006). EGFR IHC expression did not associate with overall survival in same group. Conclusions: EGFR increased gene copy number is an independent negative prognostic factor in surgically resected NA-NSCLC.

Epidermal growth factor receptor expression and gene copy number in sinonasal intestinal type adenocarcinoma

Oral Oncology ◽  
2009 ◽  
Vol 45 (9) ◽  
pp. 835-838 ◽  
Author(s):  
Alessandro Franchi ◽  
Cristina Fondi ◽  
Milena Paglierani ◽  
Monica Pepi ◽  
Oreste Gallo ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Copy Number ◽  
Gene Copy Number ◽  
Growth Factor Receptor ◽  
Receptor Expression ◽  
Gene Copy ◽  
Epidermal Growth ◽  
Intestinal Type Adenocarcinoma

Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study

2005 ◽  
Vol 6 (5) ◽  
pp. 279-286 ◽  
Author(s):  
Mauro Moroni ◽  
Silvio Veronese ◽  
Silvia Benvenuti ◽  
Giovanna Marrapese ◽  
Andrea Sartore-Bianchi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Cohort Study ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Copy Number ◽  
Gene Copy Number ◽  
Growth Factor Receptor ◽  
Gene Copy ◽  
Epidermal Growth

Epidermal growth factor receptor in glioblastomas: correlation between gene copy number and protein expression

2010 ◽  
Vol 41 (6) ◽  
pp. 815-823 ◽  
Author(s):  
Béma Coulibaly ◽  
Isabelle Nanni ◽  
Benoit Quilichini ◽  
Jean Gaudart ◽  
Philippe Metellus ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Protein Expression ◽  
Copy Number ◽  
Gene Copy Number ◽  
Growth Factor Receptor ◽  
Gene Copy ◽  
Epidermal Growth

scholarly journals Changes in Epidermal Growth Factor Receptor Gene Copy Number during Oral Carcinogenesis

2016 ◽  
Vol 25 (6) ◽  
pp. 927-935 ◽  
Author(s):  
Timothy Bates ◽  
Matthew Kennedy ◽  
Ameena Diajil ◽  
Michaela Goodson ◽  
Peter Thomson ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Copy Number ◽  
Receptor Gene ◽  
Gene Copy Number ◽  
Growth Factor Receptor ◽  
Gene Copy ◽  
Oral Carcinogenesis ◽  
Epidermal Growth
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