Single nucleotide polymorphisms in ABCC2 and ABCB1 genes and their clinical impact in physiology and drug response

2006 ◽  
Vol 234 (1) ◽  
pp. 40-50 ◽  
Author(s):  
Morimasa Wada
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Drug Response ◽  
Clinical Impact ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals In-Silico Methods for Investigating the Effect of Single Nucleotide Polymorphisms on the Structure and Function of Proteins: A Review

2019 ◽  
Author(s):  
Ebenezer Asiedu
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
In Silico ◽  
Drug Response ◽  
Fast Track ◽  
Structure And Function ◽  
Nucleotide Polymorphisms ◽  
Laboratory Studies ◽  
Single Nucleotide ◽  
And Function ◽  
In Silico Methods

Single nucleotide polymorphisms (SNP) are associated with diseases and drug response variabilities in humans. Elucidating the damaging and disease-associated SNPs using wet-laboratory approaches can be challenging and resource-demanding due to the large number of SNPs in the human genome. Due to the growth in the field of computational biology and bioinformatics, algorithms have been developed to help screen and filter out the most deleterious SNPs that are worth considering for wet-laboratory studies. Here we review the existing in-silico based methods used to predict and characterize the effects of SNPs on protein structure and function. This cutting-edge approach will facilitate the search for novel therapeutics, help understand the etiology of diseases and fast-track the personalized medicine agenda.

Single nucleotide polymorphisms as the efficient prognostic markers in breast cancer

2021 ◽  
Vol 21 ◽  
Author(s):  
Maliheh Alimardani ◽  
Meysam Moghbeli ◽  
Azam Rastgar-Moghadam ◽  
Fatemeh Homaei Shandiz ◽  
Mohammad Reza Abbaszadegan
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Single Nucleotide Polymorphisms ◽  
Drug Response ◽  
Main Body ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Drug Responses ◽  
The World ◽  
Common Malignancy

Background: Breast cancer (BC) is known as the most common malignancy in women. Environmental and genetic factors are associated with BC progression. Genetic polymorphisms have been reported as important risk factors of BC prognosis and drug response. Main body: Therefore, in the present review, we have summarized all single nucleotide polymorphisms (SNPs) which have been significantly associated with drug response in BC patients around the world. We have also categorized the reported SNPs based on their related genes functions to clarify the molecular biology of drug responses in BC. Conclusion: The majority of SNPs were reported in detoxifying enzymes, which introduced such genes as the main genetic risk factors during BC drug responses. This review paves the way for introducing a prognostic panel of SNPs for the BC patients in the world.

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