Single nucleotide polymorphisms as the efficient prognostic markers in breast cancer

Background: Breast cancer (BC) is known as the most common malignancy in women. Environmental and genetic factors are associated with BC progression. Genetic polymorphisms have been reported as important risk factors of BC prognosis and drug response. Main body: Therefore, in the present review, we have summarized all single nucleotide polymorphisms (SNPs) which have been significantly associated with drug response in BC patients around the world. We have also categorized the reported SNPs based on their related genes functions to clarify the molecular biology of drug responses in BC. Conclusion: The majority of SNPs were reported in detoxifying enzymes, which introduced such genes as the main genetic risk factors during BC drug responses. This review paves the way for introducing a prognostic panel of SNPs for the BC patients in the world.

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Use of Single-Nucleotide Polymorphisms and Mammographic Density Plus Classic Risk Factors for Breast Cancer Risk Prediction

JAMA Oncology ◽

10.1001/jamaoncol.2017.4881 ◽

2018 ◽

Vol 4 (4) ◽

pp. 476 ◽

Cited By ~ 46

Author(s):

Elke M. van Veen ◽

Adam R. Brentnall ◽

Helen Byers ◽

Elaine F. Harkness ◽

Susan M. Astley ◽

...

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Single Nucleotide Polymorphisms ◽

Risk Prediction ◽

Mammographic Density ◽

Nucleotide Polymorphisms ◽

Single Nucleotide

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β‑blockers inhibit the viability of breast cancer cells by regulating the ERK/COX‑2 signaling pathway and the drug response is affected by ADRB2 single‑nucleotide polymorphisms

Oncology Reports ◽

10.3892/or.2018.6830 ◽

2018 ◽

Cited By ~ 2

Author(s):

Wan‑Ying Xie ◽

Ruo‑Hui He ◽

Jun Zhang ◽

Yi‑Jing He ◽

Zan Wan ◽

...

Keyword(s):

Breast Cancer ◽

Single Nucleotide Polymorphisms ◽

Cancer Cells ◽

Signaling Pathway ◽

Breast Cancer Cells ◽

Drug Response ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Β Blockers ◽

Cox 2

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Statin-induced adverse effects – facts and genes

Orvosi Hetilap ◽

10.1556/oh.2013.29530 ◽

2013 ◽

Vol 154 (3) ◽

pp. 83-92

Author(s):

Mariann Harangi ◽

Noémi Zsíros ◽

Lilla Juhász ◽

György Paragh

Keyword(s):

Risk Factors ◽

Single Nucleotide Polymorphisms ◽

Adverse Effects ◽

Adverse Events ◽

Statin Therapy ◽

Significant Proportion ◽

Gene Mutations ◽

Nucleotide Polymorphisms ◽

Serious Adverse Events ◽

Single Nucleotide

Statin therapy is considered to be safe and rarely associated with serious adverse events. However, a significant proportion of patients on statin therapy show some degree of intolerance which can lead to decreased adherence to statin therapy. The authors summarize the symptoms, signs and frequencies of the most common statin-induced adverse effects and their most important risk factors including some single nucleotide polymorphisms and gene mutations. Also, they review the available approaches to detect and manage the statin-intolerant patients. Orv. Hetil., 2013, 154, 83–92.

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Faculty Opinions recommendation of Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer risk.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1116724.572795 ◽

2008 ◽

Author(s):

Paul Terry ◽

Pamela Mink

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Single Nucleotide Polymorphisms ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Discriminatory Accuracy

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Single nucleotide polymorphisms rs17335780 and rs11979255 of the epidermal growth factor receptor (EGFR) correlate with tumor size in breast cancer

The Breast ◽

10.1016/s0960-9776(21)00107-7 ◽

2021 ◽

Vol 56 ◽

pp. S25-S26

Author(s):

M. Sobočan ◽

B. Crnobrnja ◽

M. Gorenjak ◽

U. Potočnik ◽

I. Takač ◽

...

Keyword(s):

Breast Cancer ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Single Nucleotide Polymorphisms ◽

Tumor Size ◽

Growth Factor Receptor ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Epidermal Growth

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Lack of association between common UGT2B nonsynonymous single-nucleotide polymorphisms and breast cancer in populations of African ancestry

International Journal of Cancer ◽

10.1002/ijc.26300 ◽

2011 ◽

Vol 130 (11) ◽

pp. 2740-2742 ◽

Cited By ~ 3

Author(s):

Chang Sun ◽

Dezheng Huo ◽

Barbara Nemesure ◽

Anselm Hennis ◽

M. Cristina Leske ◽

...

Keyword(s):

Breast Cancer ◽

Single Nucleotide Polymorphisms ◽

African Ancestry ◽

Nucleotide Polymorphisms ◽

Single Nucleotide

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The role of functional polymorphisms in oxidative stress-related genes on early-stage breast cancer survival

The International Journal of Biological Markers ◽

10.1177/17246008211011177 ◽

2021 ◽

pp. 172460082110111

Author(s):

Erika Korobeinikova ◽

Rasa Ugenskiene ◽

Ruta Insodaite ◽

Viktoras Rudzianskas ◽

Jurgita Gudaitiene ◽

...

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Single Nucleotide Polymorphisms ◽

Early Stage ◽

Disease Free Survival ◽

Early Stage Breast Cancer ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Free Survival ◽

Disease Free

Background: Genetic variations in oxidative stress-related genes may alter the coded protein level and impact the pathogenesis of breast cancer. Methods: The current study investigated the associations of functional single nucleotide polymorphisms in the NFE2L2, HMOX1, P21, TXNRD2, and ATF3 genes with the early-stage breast cancer clinicopathological characteristics and disease-free survival, metastasis-free survival, and overall survival. A total of 202 Eastern European (Lithuanian) women with primary I–II stage breast cancer were involved. Genotyping of the single nucleotide polymorphisms was performed using TaqMan single nucleotide polymorphisms genotyping assays. Results: The CA+AA genotypes of P21 rs1801270 were significantly less frequent in patients with lymph node metastasis and larger tumor size ( P=0.041 and P=0.022, respectively). The TT genotype in ATF3 rs3125289 had significantly lower risk of estrogen receptor (ER), progesterone receptor (PR) negative, and human epidermal growth factor receptor 2 (HER2) positive status ( P=0.023, P=0.046, and P=0.040, respectively). In both, univariate and multivariate Cox analysis, TXNRD2 rs1139793 GG genotype vs. GA+AA was a negative prognostic factor for disease-free survival (multivariate hazard ratio (HR) 2.248; P=0.025) and overall survival (multivariate HR 2.248; P=0.029). The ATF3 rs11119982 CC genotype in the genotype model was a negative prognostic factor for disease-free survival (multivariate HR 5.878; P=0.006), metastasis-free survival (multivariate HR 4.759; P=0.018), and overall survival (multivariate HR 3.280; P=0.048). Conclusion: Our findings suggest that P21 rs1801270 is associated with lymph node metastasis and larger tumor size, and ATF3 rs3125289 is associated with ER, PR, and HER2 status. Two potential, novel, early-stage breast cancer survival biomarkers, TXNRD2 rs1139793 and ATF3 rs11119982, were detected. Further investigations are needed to confirm the results of the current study.

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