Nuclear translocation of apoptosis inducing factor is associated with cisplatin induced apoptosis in LNCaP prostate cancer cells

2007 ◽  
Vol 255 (1) ◽  
pp. 127-134 ◽  
Author(s):  
Wenguang Zhang ◽  
Chuanyou Zhang ◽  
Narassa Narayani ◽  
Cheng Du ◽  
K.C. Balaji
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Nuclear Translocation ◽  
Prostate Cancer Cells ◽  
Induced Apoptosis ◽  
Apoptosis Inducing Factor

Effects of titanocene dichloride derivatives on prostate cancer cells, specifically DNA damage-induced apoptosis

The Prostate ◽  
2010 ◽  
Vol 71 (2) ◽  
pp. 111-124 ◽  
Author(s):  
Sandra Cuffe ◽  
Catherine M. Dowling ◽  
James Claffey ◽  
Clara Pampillón ◽  
Megan Hogan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Damage ◽  
Cancer Cells ◽  
Titanocene Dichloride ◽  
Prostate Cancer Cells ◽  
Induced Apoptosis

Rho/ROCK/actin signaling regulates membrane androgen receptor induced apoptosis in prostate cancer cells

2008 ◽  
Vol 314 (17) ◽  
pp. 3162-3174 ◽  
Author(s):  
N PAPADOPOULOU ◽  
I CHARALAMPOPOULOS ◽  
K ALEVIZOPOULOS ◽  
A GRAVANIS ◽  
C STOURNARAS
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Induced Apoptosis ◽  
Membrane Androgen Receptor

scholarly journals PlexinB1 Promotes Nuclear Translocation of the Glucocorticoid Receptor

Cells ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 3
Author(s):  
Magali Williamson ◽  
Ritu Garg ◽  
Claire M. Wells
Keyword(s):  
Prostate Cancer ◽  
Glucocorticoid Receptor ◽  
Cancer Cells ◽  
Androgen Deprivation Therapy ◽  
Late Stage ◽  
Nuclear Translocation ◽  
Androgen Deprivation ◽  
Nuclear Localization Sequence ◽  
Prostate Cancer Cells ◽  
Localization Sequence

Androgen receptor (AR) and glucocorticoid receptor (GR) are nuclear receptors whose function depends on their entry into the nucleus where they activate transcription of an overlapping set of genes. Both AR and GR have a role in resistance to androgen deprivation therapy (ADT), the mainstay of treatment for late stage prostate cancer. PlexinB1, a receptor for semaphorins, has been implicated in various cancers including prostate cancer and has a role in resistance to ADT. We show here that activation of PlexinB1 by Sema4D and Sema3C results in translocation of endogenous GR to the nucleus in prostate cancer cells, and that this effect is dependent on PlexinB1 expression. Sema4D/Sema3C promotes the translocation of GR-GFP to the nucleus and mutation of the nuclear localization sequence (NLS1) of GR abrogates this response. These findings implicate the importin α/β system in the Sema4D/Sema3C-mediated nuclear import of GR. Knockdown of PlexinB1 in prostate cancer cells decreases the levels of glucocorticoid-responsive gene products and antagonizes the decrease in cell motility and cell area of prostate cancer cells upon dexamethasone treatment, demonstrating the functional significance of these findings. These results show that PlexinB1 activation has a role in the trafficking and activation of the nuclear receptor GR and thus may have a role in resistance to androgen deprivation therapy in late stage prostate cancer.

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