Optimization of an orthotopic murine model of head and neck squamous cell carcinoma in fully immunocompetent mice – Role of toll-like-receptor 4 expressed on host cells

2012 ◽  
Vol 317 (2) ◽  
pp. 199-206 ◽  
Author(s):  
Anne-Kristin Vahle ◽  
Alexander Kerem ◽  
Ender Öztürk ◽  
Agnes Bankfalvi ◽  
Stephan Lang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Murine Model ◽  
Host Cells ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Immunocompetent Mice

scholarly journals Rapamycin inhibits Toll-like receptor 4-induced pro-oncogenic function in head and neck squamous cell carcinoma

2014 ◽  
Vol 31 (6) ◽  
pp. 2804-2810 ◽  
Author(s):  
GUOXIN REN ◽  
JINGZHOU HU ◽  
RUNXIANG WANG ◽  
WEI HAN ◽  
MEI ZHAO ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Oncogenic Function

scholarly journals Triggering of Toll-like Receptor 4 Expressed on Human Head and Neck Squamous Cell Carcinoma Promotes Tumor Development and Protects the Tumor from Immune Attack

2009 ◽  
Vol 69 (7) ◽  
pp. 3105-3113 ◽  
Author(s):  
Miroslaw J. Szczepanski ◽  
Malgorzata Czystowska ◽  
Marta Szajnik ◽  
Malgorzata Harasymczuk ◽  
Michael Boyiadzis ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Tumor Development ◽  
Human Head ◽  
Neck Squamous Cell Carcinoma ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Immune Attack

scholarly journals Tumor microenvironment and immune evasion in head and neck squamous cell carcinoma

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Areeg Elmusrati ◽  
Justin Wang ◽  
Cun-Yu Wang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Immune System ◽  
Tumor Microenvironment ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
High Morbidity ◽  
Advanced Therapies

AbstractHead and neck squamous cell carcinoma (HNSCC), an aggressive malignancy, is characterized by high morbidity and low survival rates with limited therapeutic options outside of regional surgery, conventional cytotoxic chemotherapy, and irradiation. Increasing studies have supported the synergistic role of the tumor microenvironment (TME) in cancer advancement. The immune system, in particular, plays a key role in surveillance against the initiation, development, and progression of HNSCC. The understanding of how neoplastic cells evolve and evade the immune system whether through self-immunogenicity manipulation, or expression of immunosuppressive mediators, provides the foundation for the development of advanced therapies. Furthermore, the crosstalk between cancer cells and the host immune system have a detrimental effect on the TME promoting angiogenesis, proliferation, and metastasis. This review provides a recent insight into the role of the key inflammatory cells infiltrating the TME, with a focus on reviewing immunological principles related to HNSCC, as cancer immunosurveillance and immune escape, including a brief overview of current immunotherapeutic strategies and ongoing clinical trials.

scholarly journals Immunocompetent murine model of cancer cachexia for head and neck squamous cell carcinoma

Head & Neck ◽  
2008 ◽  
Vol 30 (3) ◽  
pp. 320-326 ◽  
Author(s):  
Trinitia Cannon ◽  
Carol Shores ◽  
Xiaoying Yin ◽  
Jason Dahlman ◽  
Denis Guttridge ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Murine Model ◽  
Cancer Cachexia ◽  
Neck Squamous Cell Carcinoma

The role of brachytherapy in the treatment of squamous cell carcinoma of the head and neck

2014 ◽  
Vol 273 (2) ◽  
pp. 269-276 ◽  
Author(s):  
Małgorzata Wierzbicka ◽  
Anna Bartochowska ◽  
Vratislav Strnad ◽  
Primož Strojan ◽  
William M. Mendenhall ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell

Role of cytokines in head and neck squamous cell carcinoma

2006 ◽  
Vol 6 (9) ◽  
pp. 1195-1203 ◽  
Author(s):  
Ralph Pries ◽  
Stefan Nitsch ◽  
Barbara Wollenberg
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma
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