The hypolipidemic activity of chitosan nanopowder prepared by ultrafine milling

2013 ◽  
Vol 95 (1) ◽  
pp. 487-491 ◽  
Author(s):  
Wei Zhang ◽  
Jiali Zhang ◽  
Qixing Jiang ◽  
Wenshui Xia
Keyword(s):  
Hypolipidemic Activity ◽  
Ultrafine Milling

Synthesis and Evaluation of the Hypoglycemic and Hypolipidemic Activity of Sulfonamide-benzothiazole Derivatives of Benzylidene-2,4- thiazolidnedione

2017 ◽  
Vol 17 (8) ◽  
pp. 721-726 ◽  
Author(s):  
Abbas Ahmadi ◽  
Mohsen Khalili ◽  
Lida Sohrabi ◽  
Nazanin Delzendeh ◽  
Babak Nahri-Niknafs ◽  
...  
Keyword(s):  
Hypolipidemic Activity ◽  
Benzothiazole Derivatives ◽  
Derivatives Of

Berberine: A Promising Natural Isoquinoline Alkaloid for the Development of Hypolipidemic Drugs

2020 ◽  
Vol 20 (28) ◽  
pp. 2634-2647
Author(s):  
Dong-Dong Li ◽  
Pan Yu ◽  
Wei Xiao ◽  
Zhen-Zhong Wang ◽  
Lin-Guo Zhao
Keyword(s):  
Clinical Trials ◽  
Animal Models ◽  
Physicochemical Properties ◽  
Isoquinoline Alkaloid ◽  
Hypolipidemic Activity ◽  
Lipid Lowering ◽  
Lipid Lowering Drug ◽  
Lipid Lowering Agent ◽  
Lowering Drug ◽  
Hypolipidemic Drugs

: Berberine, as a representative isoquinoline alkaloid, exhibits significant hypolipidemic activity in both animal models and clinical trials. Recently, a large number of studies on the lipid-lowering mechanism of berberine and studies for improving its hypolipidemic activity have been reported, but for the most part, they have been either incomplete or not comprehensive. In addition, there have been a few specific reviews on the lipid-reducing effect of berberine. In this paper, the physicochemical properties, the lipid-lowering mechanism, and studies of the modification of berberine all are discussed to promote the development of berberine as a lipid-lowering agent. Subsequently, this paper provides some insights into the deficiencies of berberine in the study of lipid-lowering drug, and based on the situation, some proposals are put forward.

Antidiabetic and Hypolipidemic Effects of Extracts of Gymnema Sylvestre in Streptozotocin Induced Type I Diabetes in Rats

2017 ◽  
Vol 12 (3) ◽  
Author(s):  
Nishtha R. Mahida ◽  
G. . Mandali ◽  
Vijaysinh V. Sindha ◽  
S. K. Raval
Keyword(s):  
Blood Glucose ◽  
Lipid Profile ◽  
Type I Diabetes ◽  
Histopathological Examination ◽  
Diabetic Control ◽  
Hypolipidemic Activity ◽  
Control Group ◽  
Type I ◽  
Gymnema Sylvestre ◽  
Altered Glucose

Gymnema sylvestre of the family Asclepiadaceae is one of the most important medicinal plants of the central eco-region. It is popularly known as Gurmar, which means “sugar killer”. Extract of leaves is reported to have tannins, gum, flavonoids, proteins and saponins. It has displayed a wide array of pharmacological activities. This study was aimed to investigate the antidiabetic and hypolipidemic effects of Gymnema sylvestre extract in experimentally induced diabetes in rats. Diabetes was produced in adult Wistar rats with single dose of streptozotocin (STZ) @ 60 mg/kg b.wt. intraperitoneally. After the confirmation of diabetes on 7th day (sugar >200 mg/dl), alcoholic and aqueous extracts of G. sylvestre (400 mg/kg) were administered orally to the experimental rats from 8th day and continued for 42 days thereafter. The antidiabetic and hypolipidemic activity was estimated by measuring blood glucose, lipid profile and histopathological examination of various tissues from all the groups. Administration of STZ resulted in a significant (p less than 0.01) increase in blood glucose and lipid profile and histopathological alterations in Diabetic control group as compared to healthy control group. Gymnema treatment demonstrated significant (p less than 0.01) antidiabetic effect indicated by restoration of blood glucose compared to STZ control group. The study concluded that extracts of Gymnema sylvestre improved the altered glucose and lipid profile in diabetic rats, suggesting that the Gymnema Sylvestre extracts exhibit the antidiabetic and hypolipidemic activity.

Hypolipidemic Activity of Allium porrum L. in Cholesterol-Fed Rabbits

2006 ◽  
Vol 9 (1) ◽  
pp. 98-101 ◽  
Author(s):  
Ahmad Movahedian ◽  
Hojjat Sadeghi ◽  
Alireza Ghannadi ◽  
Mahin Gharavi ◽  
Sepideh Azarpajooh
Keyword(s):  
Hypolipidemic Activity ◽  
Allium Porrum

Aqua-culture improved buckwheat sprouts with more abundant precious nutrients and hypolipidemic activity

2009 ◽  
Vol 60 (sup1) ◽  
pp. 232-245 ◽  
Author(s):  
Chiung-Chi Peng ◽  
Kuan-Chou Chen ◽  
Ya-Lu Yang ◽  
Li-Yun Lin ◽  
Robert Y. Peng
Keyword(s):  
Hypolipidemic Activity ◽  
Aqua Culture

Synthesis and hypolipidemic activity of new substituted (benzofuran-2-yl)-phenyl-carbinols

1988 ◽  
Vol 23 (2) ◽  
pp. 203-206 ◽  
Author(s):  
Vittorio Pestellini ◽  
Alessandro Giolitti ◽  
Franco Pasqui ◽  
Luigi Abelli ◽  
Corrado Cutrufo ◽  
...  
Keyword(s):  
Hypolipidemic Activity

Hypolipidemic Activity and Toxicity of 3-Methoxy-N,N′-diaminophthalamide in Rodents

1993 ◽  
Vol 326 (8) ◽  
pp. 467-472
Author(s):  
I. H. Hall ◽  
A. R. K. Murthy ◽  
Bruce S. Burnham
Keyword(s):  
Hypolipidemic Activity

scholarly journals Isolation and Characterization of Hypolipidemic Compound from Cajanus cajan

2011 ◽  
Vol 24 (1) ◽  
pp. 6-10
Author(s):  
M Anwar Habib ◽  
ASM Anisuzzaman ◽  
RK Barman ◽  
M Abdul Gafur ◽  
M Tofazzal Haque
Keyword(s):  
Cajanus Cajan ◽  
Methanol Extract ◽  
Fasting Blood Glucose ◽  
Hypolipidemic Activity ◽  
1H And 13C Nmr ◽  
Isolation And Characterization ◽  
Nmr Data ◽  
Biological Studies ◽  
Isolated Compound

The study was carried out to identify the compound responsible for hypolipidemic and hypoglycemic effects of Cajanus cajan (redgram). The methanol extract of redgram seeds was found to decrease fasting blood glucose and lipid profile (p<0.001) on streptozotocin-induced mice compared to control. This activity- guided fraction led to the isolation of a compound, substituted benzene containing polyhydroxy functions fused with lactone (CCA3) by analysis of 1H and 13C-NMR data. Biological studies of the isolated compound possessed prominent hypolipidemic activity. Although a number of hypoglycemic compounds are reported, yet not any hypolipidemic compound from redgram. The compound CCA3 seems to be the first report on hypolipidemic activity from methanol extract of redgram. TAJ 2011; 24(1): 6-10

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