Carboxymethyl cellulose/graphene oxide bio-nanocomposite hydrogel beads as anticancer drug carrier agent

2017 ◽  
Vol 168 ◽  
pp. 320-326 ◽  
Author(s):  
Monireh Rasoulzadeh ◽  
Hassan Namazi
Keyword(s):  
Graphene Oxide ◽  
Anticancer Drug ◽  
Carboxymethyl Cellulose ◽  
Drug Carrier ◽  
Nanocomposite Hydrogel ◽  
Hydrogel Beads

scholarly journals Carboxymethyl cellulose-grafted graphene oxide for efficient antitumor drug delivery

2018 ◽  
Vol 7 (4) ◽  
pp. 291-301 ◽  
Author(s):  
Zepeng Jiao ◽  
Bin Zhang ◽  
Chunya Li ◽  
Weicong Kuang ◽  
Jingxian Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carboxymethyl Cellulose ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Tumor Growth Inhibition

Abstract A drug delivery system based on carboxymethyl cellulose-grafted graphene oxide loaded by methotrexate (MTX/CMC-GO) with pH-sensitive and controlled drug-release properties was developed in this work. CMC was grafted on graphene oxide by ethylenediamine through hydrothermal treatment. CMC serves as a pH-sensitive trigger, while CMC-GO serves as a drug-carrying vehicle due to the curved layer and large plain surface. Different amounts of drugs could be loaded into CMC-GO nanocarriers by control of the original amount of drug/carrier ratios. Additionally, low cytotoxicity against NIH-3T3 cells and low in vivo toxicity was observed. In vivo tumor growth inhibition assays showed that MTX/CMC-GO demonstrated superior antitumor activity than free MTX against HT-29 cells. Moreover, prolonged survival time of mice was observed after MTX/CMC-GO administration. The MTX/CMC-GO drug delivery system has a great potential in colon cancer therapy.

Graphene oxide/polyacrylamide/carboxymethyl cellulose sodium nanocomposite hydrogel with enhanced mechanical strength: preparation, characterization and the swelling behavior

RSC Advances ◽  
2014 ◽  
Vol 4 (84) ◽  
pp. 44600-44609 ◽  
Author(s):  
Huijuan Zhang ◽  
Dandan Zhai ◽  
Yang He
Keyword(s):  
Compressive Strength ◽  
Graphene Oxide ◽  
Mechanical Strength ◽  
Carboxymethyl Cellulose ◽  
Swelling Behavior ◽  
Nanocomposite Hydrogel ◽  
Carboxymethyl Cellulose Sodium

A ternary GO/PAM/CMC nanocomposite hydrogel was fabricated by introducing GO into PAM/CMC hydrogels followed by ionically crosslinking of Al3+. The compressive strength of the ternary hydrogel was dramatically enhanced with the incorporation of only 1.6 wt% GO sheets.

scholarly journals Alginate/graphene double-network nanocomposite hydrogel beads with low-swelling, enhanced mechanical properties, and enhanced adsorption capacity

2016 ◽  
Vol 4 (28) ◽  
pp. 10885-10892 ◽  
Author(s):  
Yuan Zhuang ◽  
Fei Yu ◽  
Hong Chen ◽  
Jie Zheng ◽  
Jie Ma ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Graphene Oxide ◽  
Adsorption Capacity ◽  
Reduced Graphene Oxide ◽  
Nanocomposite Hydrogel ◽  
Double Network ◽  
Hydrogel Beads ◽  
Reduced Graphene ◽  
Enhanced Adsorption

We designed and prepared a novel alginate/reduced graphene oxide double-network hydrogel and investigated its mechanical properties, stability and adsorption capacity in comparison with a single network.

Multi-functionalized graphene oxide based anticancer drug-carrier with dual-targeting function and pH-sensitivity

2011 ◽  
Vol 21 (10) ◽  
pp. 3448-3454 ◽  
Author(s):  
Xiaoying Yang ◽  
Yinsong Wang ◽  
Xin Huang ◽  
Yanfeng Ma ◽  
Yi Huang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Anticancer Drug ◽  
Drug Carrier ◽  
Ph Sensitivity ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide ◽  
Dual Targeting

Graphene oxide‐carboxymethyl cellulose hydrogel beads for uptake and release study of doxorubicin

2021 ◽  
Author(s):  
Aning Ayucitra ◽  
Artik Elisa Angkawijaya ◽  
Yi‐Hsu Ju ◽  
Chintya Gunarto ◽  
Alchris Woo Go ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Carboxymethyl Cellulose ◽  
Hydrogel Beads ◽  
Cellulose Hydrogel ◽  
Release Study ◽  
Uptake And Release
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