A pH/ROS-responsive, tumor-targeted drug delivery system based on carboxymethyl chitin gated hollow mesoporous silica nanoparticles for anti-tumor chemotherapy

2020 ◽  
Vol 245 ◽  
pp. 116493 ◽  
Author(s):  
Xiao Ding ◽  
Wenjie Yu ◽  
Yunfeng Wan ◽  
Mingyue Yang ◽  
Chenghuan Hua ◽  
...  
2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Xiaoyan Xu ◽  
Chao Wu ◽  
Andi Bai ◽  
Xuan Liu ◽  
Huiling Lv ◽  
...  

The aim of this study was to prepare and characterize an innovative hepatocellular carcinoma-targeted therapeutic drug delivery system based on folate-PEG-mesoporous silica nanoparticles (FA-PEG-MSNs) loaded with paclitaxel (PTX). In vitro cell experiments and an in vivo antitumor efficacy study demonstrated that FA-PEG-MSNs-PTX produced significantly higher tumor inhibition compared with pure PTX and mesoporous silica nanoparticles loaded with paclitaxel (MSNs-PTX). The biodistribution investigation of PTX in nude mice revealed that the FA-PEG-MSNs-PTX could accumulate in tumors. Folic acid functionalized MSNs resulted in a good targeting effect, confirming that FA-PEG-MSNs-PTX is a promising tumor-targeted drug delivery system for liver cancer chemotherapy.


Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3321
Author(s):  
Etienne J. Slapak ◽  
Lily Kong ◽  
Mouad el Mandili ◽  
Rienk Nieuwland ◽  
Alexander Kros ◽  
...  

Pancreatic ductal adenocarcinoma (PDAC) has the worst survival rate of all cancers. This poor prognosis results from the lack of efficient systemic treatment regimens, demanding high-dose chemotherapy that causes severe side effects. To overcome dose-dependent toxicities, we explored the efficacy of targeted drug delivery using a protease-dependent drug-release system. To this end, we developed a PDAC-specific drug delivery system based on mesoporous silica nanoparticles (MSN) functionalized with an avidin–biotin gatekeeper system containing a protease linker that is specifically cleaved by tumor cells. Bioinformatic analysis identified ADAM9 as a PDAC-enriched protease, and PDAC cell-derived conditioned medium efficiently cleaved protease linkers containing ADAM9 substrates. Cleavage was PDAC specific as conditioned medium from leukocytes was unable to cleave the ADAM9 substrate. Protease linker-functionalized MSNs were efficiently capped with avidin, and cap removal was confirmed to occur in the presence of PDAC cell-derived ADAM9. Subsequent treatment of PDAC cells in vitro with paclitaxel-loaded MSNs indeed showed high cytotoxicity, whereas no cell death was observed in white blood cell-derived cell lines, confirming efficacy of the nanoparticle-mediated drug delivery system. Taken together, this research introduces a novel ADAM9-responsive, protease-dependent, drug delivery system for PDAC as a promising tool to reduce the cytotoxicity of systemic chemotherapy.


2018 ◽  
Vol 6 (28) ◽  
pp. 4618-4629 ◽  
Author(s):  
Lin Huang ◽  
Jia Liu ◽  
Fan Gao ◽  
Qian Cheng ◽  
Bo Lu ◽  
...  

A novel enzyme and redox dual-responsive targeted drug delivery system based on hollow mesoporous silica nanoparticles was developed for cancer therapy.


2014 ◽  
Vol 6 (23) ◽  
pp. 21677-21685 ◽  
Author(s):  
Shreya Goel ◽  
Feng Chen ◽  
Hao Hong ◽  
Hector F. Valdovinos ◽  
Reinier Hernandez ◽  
...  

2014 ◽  
Vol 2 (40) ◽  
pp. 7009-7016 ◽  
Author(s):  
Srivardhan Reddy Gayam ◽  
Shu-Pao Wu

Herein, redox responsive Pd(ii) templated rotaxane nanovalve capped mesoporous silica nanoparticles were designed for an effective cancer-targeted drug delivering system.


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