Background:
Many efforts have been explored in the last decade to treat colon cancer but
nanoparticulate drug delivery systems are making a vital contribution in the improvement of drug delivery
to colon cancer cells.
Objective:
In this review, we attempt to highlight recent advancements in the development of novel
drug delivery systems of nanoparticles for the targeted drug delivery to colon. Polymers like Epithelial
Cell Adhesion Molecule (EpCAM) aptamer chitosan, Hyaluronic Acid (HA), Chitosan (CS)–
Carboxymethyl Starch (CMS), silsesquioxane capped mesoporous silica, Near IR (NIR) fluorescent
Human Serum Albumin (HAS), poly(ethylene glycol)-conjugated hyaluronic acid etc. have been discussed
by employing various anticancer drugs like doxorubicin, oxaliplatin, paclitaxel, 5-fluorouracil
etc.
Conclusion:
These novel drug delivery systems have been determined to be more efficacious in terms
of stability, sustained and targeted drug delivery, therapeutic efficacy, improved bioavailability and enhanced
anticancer activity.
A Novel Crosslinked Hyaluronic Acid Nanogel for Drug Delivery
