scholarly journals Next generation renal denervation: chemical “perivascular” renal denervation with alcohol using a novel drug infusion catheter

2015 ◽  
Vol 16 (4) ◽  
pp. 221-227 ◽  
Author(s):  
Tim A. Fischell ◽  
David R. Fischell ◽  
Vartan E. Ghazarossian ◽  
Félix Vega ◽  
Adrian Ebner
Keyword(s):  
Renal Denervation ◽  
Next Generation ◽  
Drug Infusion ◽  
Infusion Catheter ◽  
Novel Drug

scholarly journals Alcohol-Mediated Renal Denervation Using the Peregrine System Infusion Catheter for Treatment of Hypertension

2020 ◽  
Vol 13 (4) ◽  
pp. 471-484 ◽  
Author(s):  
Felix Mahfoud ◽  
Jean Renkin ◽  
Horst Sievert ◽  
Stefan Bertog ◽  
Sebastian Ewen ◽  
...  
Keyword(s):  
Renal Denervation ◽  
Infusion Catheter ◽  
Treatment Of Hypertension

Theoretical formulation strategies towards neutralizing inter-individual variability associated with tacrolimus immunosuppressant therapy: a case study on next generation personalized medicine

2021 ◽  
Vol 22 ◽  
Author(s):  
Arun Radhakrishnan ◽  
Gowthamarajan Kuppusamy
Keyword(s):  
Drug Delivery ◽  
Personalized Medicine ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Individual Variability ◽  
Dose Titration ◽  
Next Generation ◽  
Pharmaceutical Industries ◽  
Novel Drug

: Individualizing drug therapy and attaining maximum benefits of a drug devoid of adverse reactions is the benefit of personalized medicine. One of the important factors contributing to inter-individual variability is genetic polymorphism. As of now, dose titration is the only followed golden standard for implementing personalized medicine. Converting the genotypic data into an optimized dose has become easier now due to technology development. However, for many drugs, finding an individualized dose may not be successful, which further leads to a trial and error approach. These dose titration strategies are generally followed at the clinical level, and so industrial involvement and further standardizations are not feasible. On the other side, technologically driven pharmaceutical industries have multiple smart drug delivery systems which are underutilized towards personalized medicine. Transdisciplinary research with drug delivery science can additionally support the personalization by converting the traditional concept of “dose titration towards personalization” with novel “dose-cum-dosage form modification towards next-generation personalized medicine”; the latter approach is useful to overcome gene-based inter-individual variability by either blocking, downregulating, or bypassing the biological protein generated by the polymorphic gene. This article elaborates an advanced approach to implement personalized medicine with the support of novel drug delivery systems. As a case study, we further reviewed the genetic polymorphisms associated with tacrolimus and customized novel drug delivery systems to overcome these challenges factored towards personalized medicine for better clinical outcomes, thereby paving a new strategy for implementing personalized medicine for all other drug candidates.

scholarly journals TCT-497 Arterial Media Preservation Associated with The Paradise Ultrasound Renal Denervation System: A Next generation Approach for Treating Resistant Hypertension

2013 ◽  
Vol 62 (18) ◽  
pp. B151-B152
Author(s):  
Elena Ladich ◽  
Leslie Coleman ◽  
Vincent Cabane ◽  
Kenichi Sakakura ◽  
Fumiyuki Otsuka ◽  
...  
Keyword(s):  
Resistant Hypertension ◽  
Renal Denervation ◽  
Next Generation ◽  
System A

scholarly journals Cancer Extracellular Vesicles: Next-Generation Diagnostic and Drug Delivery Nanotools

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3165
Author(s):  
Stefano Palazzolo ◽  
Lorenzo Memeo ◽  
Mohamad Hadla ◽  
Fahriye Duzagac ◽  
Agostino Steffan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Extracellular Vesicles ◽  
Cell Biology ◽  
Cell Communication ◽  
Diagnostic Tools ◽  
Next Generation ◽  
Drug Delivery Vehicles ◽  
Bodily Fluids ◽  
Novel Method ◽  
Novel Drug

Nanosized extracellular vesicles (EVs) with dimensions ranging from 100 to 1000 nm are continuously secreted from different cells in their extracellular environment. They are able to encapsulate and transfer various biomolecules, such as nucleic acids, proteins, and lipids, that play an essential role in cell‒cell communication, reflecting a novel method of extracellular cross-talk. Since EVs are present in large amounts in most bodily fluids, challengeable hypotheses are analyzed to unlock their potential roles. Here, we review EVs by discussing their specific characteristics (structure, formation, composition, and isolation methods), focusing on their key role in cell biology. Furthermore, this review will summarize the biomedical applications of EVs, in particular those between 30 and 150 nm (like exosomes), as next-generation diagnostic tools in liquid biopsy for cancer and as novel drug delivery vehicles.

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