scholarly journals Tracing total and dissolved material in a western Canadian basin using quality control samples to guide the selection of fingerprinting parameters for modelling

CATENA ◽  
2021 ◽  
Vol 200 ◽  
pp. 105095
Author(s):  
J.P. Laceby ◽  
P.V.G. Batista ◽  
N. Taube ◽  
M.K. Kruk ◽  
C. Chung ◽  
...  
Keyword(s):  
Quality Control ◽  
Canadian Basin ◽  
Selection Of ◽  
Control Samples

scholarly journals Expanding HadISD: quality-controlled, sub-daily station data from 1931

2016 ◽  
Author(s):  
Robert J. H. Dunn ◽  
Kate M. Willett ◽  
David E. Parker ◽  
Lorna Mitchell
Keyword(s):  
Quality Control ◽  
Wind Speed ◽  
Time Range ◽  
Underlying Structure ◽  
Control Procedure ◽  
Future Projections ◽  
Quality Control Procedure ◽  
Temporal Coverage ◽  
Extremes Of Temperature ◽  
Selection Of

Abstract. HadISD is a sub-daily, station-based, quality-controlled dataset designed to study past extremes of temperature, pressure and humidity and allow comparisons to future projections. Herein we describe the first major update to the HadISD dataset. The temporal coverage of the dataset has been extended to 1931 to present, doubling the time range over which data are provided. Improvements made to the station selection and merging procedures result in 7677 stations being provided in version 2.0.0.2015p of this dataset. The selection of stations to merge together making composites has also been improved and made more robust. The underlying structure of the quality control procedure is the same as for HadISD.1.0.x, but a number of improvements have been implemented in individual tests. Also, more detailed quality control tests for wind speed and direction have been added. The data will be made available as netCDF files at www.metoffice.gov.uk/hadobs/hadisd and updated annually.

scholarly journals An Easily Overlooked Contamination of Syringes in Newborn Screening by Tandem Mass Spectrometry

2021 ◽  
Vol 8 ◽  
Author(s):  
Yanyun Wang ◽  
Yun Sun ◽  
Tao Jiang
Keyword(s):  
Mass Spectrometry ◽  
Quality Control ◽  
Tandem Mass Spectrometry ◽  
Newborn Screening ◽  
Retrospective Analysis ◽  
Tandem Mass ◽  
Patient Sample ◽  
Important Test ◽  
Control Samples

Background: Tandem mass spectrometry becomes a common and important test in newborn screening, but potential contamination of the equipment has largely been ignored.Methods: The source of contamination through Biosan quality control samples was examined prospectively, and further confirmed by retrospective analysis of patient samples.Results: We found that the source of contamination came from a syringe in the Biosan quality control samples. Furthermore, we found that a large number of indicators in the patient sample were interfered by syringe contamination in our center, and also in two other newborn screening centers, but the affected indicators were different in different screening centers.Conclusion: Syringe contamination will affect the detection of patient samples by tandem mass spectrometry and should be monitored carefully and immediately.

scholarly journals Comparison of statistical methods and the use of quality control samples for batch effect correction in human transcriptome data

PLoS ONE ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. e0202947 ◽  
Author(s):  
Almudena Espín-Pérez ◽  
Chris Portier ◽  
Marc Chadeau-Hyam ◽  
Karin van Veldhoven ◽  
Jos C. S. Kleinjans ◽  
...  
Keyword(s):  
Quality Control ◽  
Statistical Methods ◽  
Batch Effect ◽  
Transcriptome Data ◽  
Human Transcriptome ◽  
Control Samples

scholarly journals The phenomenon of zinc deficiency among children in China aged 3–5 years old

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Ye Bi ◽  
Zhenyu Yang ◽  
Xuehong Pang ◽  
Yifan Duan ◽  
Jianqiang Lai ◽  
...  
Keyword(s):  
Quality Control ◽  
Zinc Deficiency ◽  
Rural Areas ◽  
Serum Zinc ◽  
Zinc Level ◽  
Urban Children ◽  
Rural Children ◽  
Country Level ◽  
Multi Stage ◽  
Control Samples

AbstractIntroductionzinc is an essential micro-nutrient for growth and proper immune function. Yet there are limited data available on the prevalence of zinc deficiency among children aged 3–5 at the country level. This information will enable health planners to determine the need for zinc intervention activities and to stimulate further research into these areas.materials and methodsThe data on children aged 3–5 were extracted from the Chinese National Nutrition and Health Surveillance in 2013. By multi-stage stratified cluster randomly sampling method, 30 children aged 3–5 years old were selected from each region for this study from 55 counties in China to analyze serum zinc. Finally, 1472 children aged 3–5 years were included in the study. The concentration of serum zinc was determined by high resolution inductively coupled plasm mass spectrometry. High and low level quality control samples were used, measured value was (1.63 ± 0.04)mg/l and (2.80 ± 0.06)mg/l, respectively. CV of quality control samples were 1.69%~2.45%. The zinc deficiency was defined as serum zinc level < 70μg/dl with the standard of WHO.Resultsserum zinc means of children aged 3–5 years was (95.3 ± 18.2)μg/dl and 3.9% children with zinc deficiency. serum zinc means level in urban children was (98.9 ± 17.6)μg/dl, and (91.6 ± 18.2)μg/dl in rural area. we showed that the serum zinc deficiency rate was higher in rural children (5.5%) than urban children (2.4%), and there were significant differences between these two areas. serum zinc means level in boys aged 3–5 years was (95.3 ± 18.7)μg/dl, and (95.3 ± 17.8)μg/dl in girls aged 3–5 years old. The prevalence of zinc deficiency was 1.5%, 6.6% and 1.8% in 3~,4~,5~ years old urban boys, respectively; 6.8%, 7.7% and 4.0% in rural boys, respectively. The prevalence of zinc deficiency was 2.3%, 0.8% and 1.7% in 3~,4~,5~ years old urban girls, respectively; 4.1%, 7.0% and 4.0% in rural girls, respectively. And there were differences between urban and rural areas in girls of 4~.5 years.DiscussionThe zinc level of children aged 3–5 years in China has been improved compared with ten years ago, but the zinc deficiency of rural children is still lower than that of urban children, especially those aged 4 to 5 years in rural areas, so we should pay more attention to this group.

scholarly journals Chemical Biology Framework to Illuminate Proteostasis

2020 ◽  
Vol 89 (1) ◽  
pp. 529-555 ◽  
Author(s):  
Rebecca M. Sebastian ◽  
Matthew D. Shoulders
Keyword(s):  
Quality Control ◽  
Protein Folding ◽  
Chemical Biology ◽  
Control Factors ◽  
Network Composition ◽  
Network Component ◽  
Selection Of ◽  
In Cells

Protein folding in the cell is mediated by an extensive network of >1,000 chaperones, quality control factors, and trafficking mechanisms collectively termed the proteostasis network. While the components and organization of this network are generally well established, our understanding of how protein-folding problems are identified, how the network components integrate to successfully address challenges, and what types of biophysical issues each proteostasis network component is capable of addressing remains immature. We describe a chemical biology–informed framework for studying cellular proteostasis that relies on selection of interesting protein-folding problems and precise researcher control of proteostasis network composition and activities. By combining these methods with multifaceted strategies to monitor protein folding, degradation, trafficking, and aggregation in cells, researchers continue to rapidly generate new insights into cellular proteostasis.

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