Ginsenoside Rg2 protects PC12 cells against β-amyloid25-35-induced apoptosis via the phosphoinositide 3-kinase/Akt pathway

2017 ◽  
Vol 275 ◽  
pp. 152-161 ◽  
Author(s):  
Jing Cui ◽  
Jiao Wang ◽  
Meizhu Zheng ◽  
Dongxia Gou ◽  
Chunming Liu ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Akt Pathway ◽  
Phosphoinositide 3 Kinase ◽  
Induced Apoptosis

scholarly journals A p53-Phosphoinositide Signalosome Regulates Nuclear Akt Activation

2021 ◽  
Author(s):  
Mo Chen ◽  
Suyong Choi ◽  
Tianmu Wen ◽  
Changliang Chen ◽  
Narendra Thapa ◽  
...  
Keyword(s):  
Genotoxic Stress ◽  
Akt Pathway ◽  
Mutant P53 ◽  
Tumor Suppressor P53 ◽  
Wild Type ◽  
Akt Activation ◽  
Pi3k Inhibitors ◽  
Phosphoinositide 3 Kinase ◽  
Induced Apoptosis ◽  
Dependent Mechanism

The tumor suppressor p53 and the phosphoinositide 3-kinase (PI3K)-Akt pathway have fundamental roles in regulating cell growth, apoptosis and are frequently mutated in cancer. Here, we show that genotoxic stress induces nuclear Akt activation by a p53-dependent mechanism that is independent from the canonical membrane-localized PI3K-Akt pathway. Upon genotoxic stress a nuclear p53-PI3,4,5P3 complex is generated in regions devoid of membranes by a nuclear PI3K, and this complex recruits all the kinases required to activate Akt and phosphorylate FOXOs, inhibiting DNA damage-induced apoptosis. Wild-type p53 activates nuclear Akt in an on/off fashion upon stress, whereas mutant p53 stimulates high basal Akt activity, indicating a fundamental difference. The nuclear p53-phosphoinositide signalosome is distinct from the canonical membrane-localized pathway and insensitive to PI3K inhibitors currently in the clinic, underscoring its therapeutic relevance.

Salidroside protects PC12 cells from MPP+-induced apoptosis via activation of the PI3K/Akt pathway

2012 ◽  
Vol 50 (8) ◽  
pp. 2591-2597 ◽  
Author(s):  
Lingling Zhang ◽  
Wenjun Ding ◽  
Huixing Sun ◽  
Qiong Zhou ◽  
JingQun Huang ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Akt Pathway ◽  
Induced Apoptosis

Neuroprotective Effect of Fucoidan on H2O2-Induced Apoptosis in PC12 Cells Via Activation of PI3K/Akt Pathway

2012 ◽  
Vol 32 (4) ◽  
pp. 523-529 ◽  
Author(s):  
Yonglin Gao ◽  
Chaohua Dong ◽  
Jungang Yin ◽  
Jingyu Shen ◽  
Jingwei Tian ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Neuroprotective Effect ◽  
Akt Pathway ◽  
Induced Apoptosis

scholarly journals Erythropoietin prevents PC12 cells from beta-amyloid-induced apoptosis via PI3K⁄Akt pathway

2012 ◽  
Vol 1 (1) ◽  
pp. 7 ◽  
Author(s):  
Sun Zhi-Kun ◽  
Yang Hong-Qi ◽  
Wang Zhi-Quan ◽  
Pan Jing ◽  
Hong Zhen ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Beta Amyloid ◽  
Akt Pathway ◽  
Induced Apoptosis

Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway

2006 ◽  
Vol 1113 (1) ◽  
pp. 10-23 ◽  
Author(s):  
Hirofumi Fujita ◽  
Tetsuya Ogino ◽  
Hirotsugu Kobuchi ◽  
Takuzo Fujiwara ◽  
Hiromi Yano ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Akt Pathway ◽  
Camp Analog ◽  
Induced Apoptosis ◽  
6 Hydroxydopamine

Tacrine(2)–ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway

2011 ◽  
Vol 59 (7) ◽  
pp. 981-988 ◽  
Author(s):  
Huan Zhang ◽  
Shinghung Mak ◽  
Wei Cui ◽  
Wenming Li ◽  
Renwen Han ◽  
...  
Keyword(s):  
Ferulic Acid ◽  
Pc12 Cells ◽  
Akt Pathway ◽  
Induced Apoptosis ◽  
6 Hydroxydopamine
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