Mechanistic target of rapamycin (mTOR) signaling genes in decapod crustaceans: Cloning and tissue expression of mTOR, Akt, Rheb, and p70 S6 kinase in the green crab, Carcinus maenas, and blackback land crab, Gecarcinus lateralis

2014 ◽  
Vol 168 ◽  
pp. 25-39 ◽  
Author(s):  
Ali M. Abuhagr ◽  
Kyle S. MacLea ◽  
Ernest S. Chang ◽  
Donald L. Mykles
Keyword(s):  
Carcinus Maenas ◽  
Tissue Expression ◽  
Mtor Signaling ◽  
Green Crab ◽  
Target Of Rapamycin ◽  
Decapod Crustaceans ◽  
S6 Kinase ◽  
P70 S6 Kinase ◽  
Land Crab ◽  
Mechanistic Target Of Rapamycin

scholarly journals Immunopurified Mammalian Target of Rapamycin Phosphorylates and Activates p70 S6 Kinase αin Vitro

1999 ◽  
Vol 274 (48) ◽  
pp. 34493-34498 ◽  
Author(s):  
Shuji Isotani ◽  
Kenta Hara ◽  
Chiharu Tokunaga ◽  
Hitomi Inoue ◽  
Joseph Avruch ◽  
...  
Keyword(s):  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
S6 Kinase ◽  
P70 S6 Kinase

scholarly journals Diazoxide preconditioning is mediated by mechanistic target of rapamycin (mTOR) and S6 Kinase (S6K)

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Somhrita Dutta ◽  
Ibolya Rutkai ◽  
Korey Walter ◽  
Prasad Katakam ◽  
David Busija
Keyword(s):  
Target Of Rapamycin ◽  
S6 Kinase ◽  
Mechanistic Target Of Rapamycin

Role of mTor signaling for tubular function and disease

Physiology ◽  
2021 ◽  
Author(s):  
Florian Grahammer ◽  
Tobias B Huber ◽  
Ferruh Artunc
Keyword(s):  
Diabetic Nephropathy ◽  
Actin Cytoskeleton ◽  
Mtor Signaling ◽  
Tubular Function ◽  
Target Of Rapamycin ◽  
Multiprotein Complexes ◽  
Mechanistic Target Of Rapamycin ◽  
Transport Regulation ◽  
Disease Entities

The mechanistic target of rapamycin (mTOR) forms two distinct intracellular multiprotein complexes that control a multitude of intracellular processes linked to metabolism, proliferation, actin cytoskeleton and survival. Recent studies have identified the importance of these complexes for transport regulation of ions and nutrients along the entire nephron. First reports could link altered activity of these complexes to certain disease entities i.e. diabetic nephropathy, AKI or hyperkalemia.

Activation of mammalian target of rapamycin and the p70 S6 kinase by arsenic trioxide in BCR-ABL–expressing cells

2006 ◽  
Vol 5 (11) ◽  
pp. 2815-2823 ◽  
Author(s):  
Patrick Yoon ◽  
Nick Giafis ◽  
Jessica Smith ◽  
Heather Mears ◽  
Efstratios Katsoulidis ◽  
...  
Keyword(s):  
Arsenic Trioxide ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
S6 Kinase ◽  
P70 S6 Kinase

scholarly journals Mechanistic target of rapamycin signaling in mouse models of accelerated aging

2019 ◽  
Vol 75 (1) ◽  
pp. 64-72 ◽  
Author(s):  
Jin Young Lee ◽  
Brian K Kennedy ◽  
Chen-Yu Liao
Keyword(s):  
Mouse Models ◽  
Accelerated Aging ◽  
Nutrient Sensing ◽  
Mtor Signaling ◽  
Human Diseases ◽  
Target Of Rapamycin ◽  
Cellular Processes ◽  
Positive Effects ◽  
Mechanistic Target Of Rapamycin ◽  
Age Related

Abstract The mechanistic target of rapamycin (mTOR) is an essential nutrient-sensing kinase that integrates and regulates a number of fundamental cellular processes required for cell growth, cell motility, translation, metabolism, and autophagy. mTOR signaling has been implicated in the progression of many human diseases, and its dysregulation has been reported in several pathological processes, especially in age-related human diseases and mouse models of accelerated aging. In addition, many studies have demonstrated that the regulation of mTOR activity has a beneficial effect on longevity in several mouse models of aging. However, not all mouse models of accelerated aging show positive effects on aging-associated phenotypes in response to targeting mTOR signaling. Here, we review the effects of interventions that modulate mTOR signaling on aging-related phenotypes in different mouse models of accelerated aging and discuss their implications with respect to aging and aging-related disorders.

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