WITHDRAWN: Dual display bacteriophage as a platform for high sensitive detection of serum p53 antibodies in breast cancer patients

BACKGROUND: Apoptosis inhibition is a major tumorigenic factor. Bcl-2 dysregulation and TP53 mutation status, which may correlate with autoantibody generation, contribute to impaired apoptosis. OBJECTIVE: This study aimed to investigate the prognostic value of circulating Bcl-2 and anti-p53 antibodies (p53Abs) in a 17.5-year follow-up of breast cancer patients. We also analyzed the correlations of Bcl-2 and p53Abs with various clinicopathological parameters in order to assess their impact on tumor aggressiveness. METHODS: Serum Bcl-2 and p53Abs levels were analyzed by the enzyme-linked immunosorbent assay (ELISA) in 82 patients with invasive breast cancer and twenty individuals without malignancy. RESULTS: Serum Bcl-2 and p53Abs levels in breast cancer patients were significantly higher than those in controls. Patients with high levels of Bcl-2 (cut-off 200 U/ml) had a poorer prognosis (17.5-year survival) than those with lower Bcl-2 values. In combined analysis the subgroup of patients with elevated p53Abs (cut-off 15 U/ml) and elevated Bcl-2 (cut-offs 124 U/ml and 200 U/ml) had the worse prognosis in 17.5-year survival. In correlation analysis p53Abs and Bcl-2 were associated with unfavorable clinicopathological parameters. CONCLUSIONS: Our results suggest that breast cancer patients with high serum levels of p53Abs and Bcl-2 present an especially unfavorable group in a long follow-up.

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Changing pattern of tumor markers in recurrent colorectal cancer patients before surgery to recurrence: serum p53 antibodies, CA19-9 and CEA

International Journal of Clinical Oncology ◽

10.1007/s10147-019-01597-6 ◽

2019 ◽

Vol 25 (4) ◽

pp. 622-632 ◽

Cited By ~ 5

Author(s):

Mitsunori Ushigome ◽

Hideaki Shimada ◽

Yasuyuki Miura ◽

Kimihiko Yoshida ◽

Tomonori Kaneko ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Patients ◽

Tumor Markers ◽

Recurrent Colorectal Cancer ◽

P53 Antibodies ◽

Serum P53 Antibodies ◽

Colorectal Cancer Patients ◽

Serum P53

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Clinical Significance of Measuring Serum p53 Antibodies in Colorectal Cancer Patients

The Japanese Journal of Gastroenterological Surgery ◽

10.5833/jjgs.43.996 ◽

2010 ◽

Vol 43 (9) ◽

pp. 996-1001 ◽

Cited By ~ 1

Author(s):

Mitsuyoshi Ota ◽

Shoichi Fujii ◽

Yasushi Ichikawa ◽

Hirokazu Suwa ◽

Kenji Tatsumi ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Patients ◽

Clinical Significance ◽

P53 Antibodies ◽

Serum P53 Antibodies ◽

Colorectal Cancer Patients ◽

Serum P53

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Highly Sensitive Detection of HER2 Extracellular Domain in the Serum of Breast Cancer Patients by Piezoelectric Microcantilevers

Analytical Chemistry ◽

10.1021/ac103301r ◽

2011 ◽

Vol 83 (9) ◽

pp. 3392-3397 ◽

Cited By ~ 45

Author(s):

LiNa Loo ◽

Joseph A. Capobianco ◽

Wei Wu ◽

Xiaotong Gao ◽

Wan Y. Shih ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Extracellular Domain ◽

Sensitive Detection ◽

Breast Cancer Patients ◽

Highly Sensitive ◽

Highly Sensitive Detection

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Highly sensitive detection of the MGB1 transcript (mammaglobin) in the peripheral blood of breast cancer patients

International Journal of Cancer ◽

10.1002/ijc.11609 ◽

2003 ◽

Vol 108 (4) ◽

pp. 592-595 ◽

Cited By ~ 23

Author(s):

Nuno Cerveira ◽

Lurdes Torres ◽

Patr�cia Rocha ◽

Susana Bizarro ◽

Deolinda Pereira ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Peripheral Blood ◽

Sensitive Detection ◽

Breast Cancer Patients ◽

Highly Sensitive ◽

Highly Sensitive Detection

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Clinical Significance of Serum p53 Antibodies in Oral Cancer

Tumori Journal ◽

10.1177/030089160609200209 ◽

2006 ◽

Vol 92 (2) ◽

pp. 134-139 ◽

Cited By ~ 7

Author(s):

Rachana Narendra Singh Sainger ◽

Manisha Hasmukhray Shah ◽

Amisha Anil Desai ◽

Shilin Nandubhai Shukla ◽

Pankaj Manubhai Shah ◽

...

Keyword(s):

Oral Cancer ◽

Cancer Patients ◽

Clinical Significance ◽

P53 Antibodies ◽

Incidence And Mortality ◽

Serum P53 Antibodies ◽

Antibody Positivity ◽

Oral Cancer Patients ◽

Serum P53 ◽

P53 Antibody

Aim and Background The incidence and mortality due to oral cancer have increased worldwide. In India, the use of tobacco has been found to be the major etiological factor for the development of oral cancers. Various studies on serum p53 antibodies have suggested their clinical importance as prognostic markers in cancer. However, there is a dearth of data on serum p53 antibodies in oral cancer patients in India. The present study was carried to evaluate the clinical significance of serum p53 antibodies in oral cancer. Materials and Methods The serum p53 antibody status was analyzed by means of ELISA in 55 healthy individuals, 60 patients with oral precancerous conditions, 75 untreated oral cancer patients, and 86 follow-up blood samples of the oral cancer patients. Results We found serum p53 antibodies in 23% of cancer patients. The frequency of p53 antibody positivity was higher in patients with lymph node metastasis, advanced disease and well-differentiated tumors. Furthermore, p53 antibody positivity strongly correlated with poor treatment outcome in cancer patients. Kaplan-Meier survival analysis showed significantly poorer disease-free survival in patients with serum p53 antibodies. Conclusion The results of this study suggest the usefulness of serum p53 antibodies in the prognostication of oral cancer patients.

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