Lipoprotein (a) is a risk factor for coronary artery disease in Chinese Han ethnic population modified by some traditional risk factors: A cross-sectional study of 3462 cases and 6125 controls

2015 ◽  
Vol 451 ◽  
pp. 278-286 ◽  
Author(s):  
Dong-Ping Cai ◽  
Yong-Ming He ◽  
Xiang-Jun Yang ◽  
Xin Zhao ◽  
Hai-Feng Xu
Medicine ◽  
2021 ◽  
Vol 100 (39) ◽  
pp. e27350
Author(s):  
Chacko Pearl Dain ◽  
Sanjay Ganapathi ◽  
Zachariah Geevar ◽  
Sivadasanpillai Harikrishnan ◽  
Jayanthi Viswanathan Ammu ◽  
...  

Author(s):  
Milena Slobodan Pandrc ◽  
Nenad Ratković ◽  
Vitomir Perić ◽  
Maja Stojanović ◽  
Vanja Kostovski ◽  
...  

Background: It is well known that less than 1% of the population achieves ideal cardiovascular health as well as 65% of patients do not have their conventional risk biomarkers under control. The military service has its own  particularities that may contribute to the cardiovascular risk . Methods: In order to define the preventive strategy goals, we analyzed the prevalence of traditional cardiovascular risk factors for coronary artery disease and elevated fibrinogen among active military personnel in Republic of Serbia.   Results: The cross-sectional study included 738 individuals older than 20 years, mostly between 31 and 40 years old. The mean value of SBP for the whole group was 122.39±9.42 mmHg, and for the DBP 79.94±6.56 mmHg. Among active military personnel 72.7% (533), had prehypertension and 13.8% (101) was hypertensive. Both body mass and BMI index among the observed age subgroups were found to increase with the age of the patients, as well as cholesterol values. HDL cholesterol values ​​also differed statistically significantly between age subgroups, with the proportion of individuals with HDL less than 1.5 mmol / L in all subgroups was about 85%, the only in the 41-50 age group was lower, 76.4%. LDL cholesterol, as well as the proportion of individuals who had LDL ≥3.5, increases with the age of patients, and an identical trend was recorded with triglycerides. With aging, fibrinogen levels increased. Conclusions: Those findings considering cardio and cerebrovascular risk factors would help to create the new approach for primary prevention for these categories of individuals.


2020 ◽  
Vol 9 (11) ◽  
pp. 5629
Author(s):  
MohammadAzhar Rashikh ◽  
AbdulmgeedFahhad H. Alruways ◽  
NemerAbdulaziz Alotaibi ◽  
AliAlhumaidi Alnufeie ◽  
YosefJazza D. Alshammari ◽  
...  

2013 ◽  
Vol 131 (5) ◽  
pp. 296-300 ◽  
Author(s):  
Antonio Ivo Moritz Neto ◽  
Joel Rolim de Moura Junior ◽  
Darlene Camati Persuhn

CONTEXT AND OBJECTIVE: Atherosclerotic disease is the leading cause of death in Brazil. It is a complex disease and its prevention involves identification and control of risk factors. Moderately increased plasma homocysteine concentration (hyperhomocysteinemia) has been considered to be a risk factor for several vascular diseases. Mutations in the methylenetetrahydrofolate reductase (MTHFR) enzyme, which is involved in homocysteine metabolism, have been investigated as potential vascular disease risk factors. G1793A polymorphism was described in 2002 and there are few studies analyzing its involvement in diseases. The objective of this study was to investigate the prevalence of G1793A polymorphism in subjects with early coronary artery disease (CAD). DESIGN AND SETTING: Cross-sectional study with control group conducted at a private cardiology clinic and a molecular biology laboratory (Universidade do Vale do Itajaí). METHODS: We studied 74 early-onset CAD+ patients and 40 CAD- individuals with normal angiography results. DNA was extracted from blood samples. Molecular data were obtained via PCR/RFLP and agarose gel electrophoresis. RESULTS: The occurrence of G1793A heterozygotes was similar in the control (5%) and test (6.25%) groups, thus showing that in the population studied there was no correlation between the marker and occurrences of early CAD. There was also no association between the polymorphism and the risk factors for atherosclerosis. CONCLUSIONS: The frequency of the 1793A allele in the test group (3.4%) was similar to what was found in the control individuals (2.5%). There was no correlation between G1793A polymorphism and occurrences of early CAD in this population.


Sign in / Sign up

Export Citation Format

Share Document