scholarly journals PREVALENCE OF TRADITIONAL CARDIOVASCULAR RISK FACTORS FOR CORONARY ARTERY DISEASE AND ELEVATED FIBRINOGEN AMONG ACTIVE MILITARY PERSONNEL IN REPUBLIC OF SERBIA: A CROSS-SECTIONAL STUDY

Author(s):  
Milena Slobodan Pandrc ◽  
Nenad Ratković ◽  
Vitomir Perić ◽  
Maja Stojanović ◽  
Vanja Kostovski ◽  
...  

Background: It is well known that less than 1% of the population achieves ideal cardiovascular health as well as 65% of patients do not have their conventional risk biomarkers under control. The military service has its own  particularities that may contribute to the cardiovascular risk . Methods: In order to define the preventive strategy goals, we analyzed the prevalence of traditional cardiovascular risk factors for coronary artery disease and elevated fibrinogen among active military personnel in Republic of Serbia.   Results: The cross-sectional study included 738 individuals older than 20 years, mostly between 31 and 40 years old. The mean value of SBP for the whole group was 122.39±9.42 mmHg, and for the DBP 79.94±6.56 mmHg. Among active military personnel 72.7% (533), had prehypertension and 13.8% (101) was hypertensive. Both body mass and BMI index among the observed age subgroups were found to increase with the age of the patients, as well as cholesterol values. HDL cholesterol values ​​also differed statistically significantly between age subgroups, with the proportion of individuals with HDL less than 1.5 mmol / L in all subgroups was about 85%, the only in the 41-50 age group was lower, 76.4%. LDL cholesterol, as well as the proportion of individuals who had LDL ≥3.5, increases with the age of patients, and an identical trend was recorded with triglycerides. With aging, fibrinogen levels increased. Conclusions: Those findings considering cardio and cerebrovascular risk factors would help to create the new approach for primary prevention for these categories of individuals.

Medicine ◽  
2021 ◽  
Vol 100 (39) ◽  
pp. e27350
Author(s):  
Chacko Pearl Dain ◽  
Sanjay Ganapathi ◽  
Zachariah Geevar ◽  
Sivadasanpillai Harikrishnan ◽  
Jayanthi Viswanathan Ammu ◽  
...  

2020 ◽  
Vol 9 (11) ◽  
pp. 5629
Author(s):  
MohammadAzhar Rashikh ◽  
AbdulmgeedFahhad H. Alruways ◽  
NemerAbdulaziz Alotaibi ◽  
AliAlhumaidi Alnufeie ◽  
YosefJazza D. Alshammari ◽  
...  

2013 ◽  
Vol 131 (5) ◽  
pp. 296-300 ◽  
Author(s):  
Antonio Ivo Moritz Neto ◽  
Joel Rolim de Moura Junior ◽  
Darlene Camati Persuhn

CONTEXT AND OBJECTIVE: Atherosclerotic disease is the leading cause of death in Brazil. It is a complex disease and its prevention involves identification and control of risk factors. Moderately increased plasma homocysteine concentration (hyperhomocysteinemia) has been considered to be a risk factor for several vascular diseases. Mutations in the methylenetetrahydrofolate reductase (MTHFR) enzyme, which is involved in homocysteine metabolism, have been investigated as potential vascular disease risk factors. G1793A polymorphism was described in 2002 and there are few studies analyzing its involvement in diseases. The objective of this study was to investigate the prevalence of G1793A polymorphism in subjects with early coronary artery disease (CAD). DESIGN AND SETTING: Cross-sectional study with control group conducted at a private cardiology clinic and a molecular biology laboratory (Universidade do Vale do Itajaí). METHODS: We studied 74 early-onset CAD+ patients and 40 CAD- individuals with normal angiography results. DNA was extracted from blood samples. Molecular data were obtained via PCR/RFLP and agarose gel electrophoresis. RESULTS: The occurrence of G1793A heterozygotes was similar in the control (5%) and test (6.25%) groups, thus showing that in the population studied there was no correlation between the marker and occurrences of early CAD. There was also no association between the polymorphism and the risk factors for atherosclerosis. CONCLUSIONS: The frequency of the 1793A allele in the test group (3.4%) was similar to what was found in the control individuals (2.5%). There was no correlation between G1793A polymorphism and occurrences of early CAD in this population.


BMJ Open ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. e031799
Author(s):  
Loredana Elisabeta Popa ◽  
Bianca Petresc ◽  
Cristina Cătană ◽  
Claudia Gabriela Moldovanu ◽  
Diana Sorina Feier ◽  
...  

ObjectivesThis study aimed to evaluate the association between cardiovascular risk factors and Coronary Artery Disease—Reporting and Data System (CAD-RADS) score in the Romanian population. CAD-RADS is a new, standardised method to assess coronary artery disease (CAD) using coronary CT angiography (CCTA).DesignA cross-sectional observational, patient-based study.SettingReferred imaging centre for CAD in Transylvania, Romania.ParticipantsWe retrospectively reviewed 674 patients who underwent CCTA between January 2017 and August 2018. The exclusion criteria included: previously known CAD, defined as prior myocardial infarction, percutaneous coronary intervention or coronary artery bypass graft surgery (n=91), cardiac CT for other than evaluation of possible CAD (n=85), significant arrhythmias compromising imaging quality (n=23). Finally, 475 patients fulfilled the inclusion criteria.MethodsDemographical, clinical and CCTA characteristics of the patients were obtained. CAD was evaluated using CAD-RADS score. Obstructive CAD was defined as ≥50% stenosis of ≥1 coronary segment on CCTA.ResultsWe evaluated the association between risk factors and CAD-RADS score in univariate and multivariable analysis. We divided the patients into two groups according to the CAD-RADS system: group 1: CAD-RADS score between 0 and 2 (stenosis <50%) and group 2: CAD-RADS score ≥3 (stenosis ≥50%). On univariate analysis, male gender, age, hypertension, dyslipidaemia, smoking and diabetes mellitus were positively associated with a CAD-RADS score ≥3. The multivariate analysis showed that male sex, age, dyslipidaemia, hypertension and smoking were independently associated with obstructive CAD.ConclusionThis study demonstrated a significant association between multiple cardiovascular risk factors and a higher coronary atherosclerotic burden assessed using CAD-RADS system in the Romanian population.


2019 ◽  
Vol Volume 12 ◽  
pp. 63-70 ◽  
Author(s):  
Mohammed Ali Almalki ◽  
Maram Nader AlJishi ◽  
Maie Abdulrhman Khayat ◽  
Hotoun Fayez Bokhari ◽  
Ahmed Hussein Subki ◽  
...  

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