Synthesis of quaternary 8-(1-acylethene-1-yl)-13-methylcoptisine chlorides and their selective growth inhibitory activity between human cancer cell lines and normal intestinal epithelial cell-6

2018 ◽  
Vol 29 (1) ◽  
pp. 131-135 ◽  
Author(s):  
Zhi-Hui Zhang ◽  
Yu Yan ◽  
An-Jun Deng ◽  
Hai-Jing Zhang ◽  
Zhi-Hong Li ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Lines ◽  
Inhibitory Activity ◽  
Intestinal Epithelial Cell ◽  
Human Cancer ◽  
Intestinal Epithelial ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity

Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines

2008 ◽  
Vol 18 (24) ◽  
pp. 6451-6453 ◽  
Author(s):  
Naoto Kojima ◽  
Hiromi Hayashi ◽  
Satoshi Suzuki ◽  
Hiroaki Tominaga ◽  
Naoyoshi Maezaki ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Inhibitory Activity ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity

scholarly journals New Bioactive Fused Triazolothiadiazoles as Bcl-2-Targeted Anticancer Agents

2021 ◽  
Vol 22 (22) ◽  
pp. 12272
Author(s):  
Rania Hamdy ◽  
Arwyn T. Jones ◽  
Mohamed El-Sadek ◽  
Alshaimaa M. Hamoda ◽  
Sarra B. Shakartalla ◽  
...  
Keyword(s):  
Binding Affinity ◽  
Cell Lines ◽  
Anticancer Agents ◽  
Inhibitory Activity ◽  
Human Cancer ◽  
Drug Candidate ◽  
Human Cancer Cell Lines ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Ic50 Values

A series of 3-(6-substituted phenyl-[1,2,4]-triazolo[3,4-b]-[1,3,4]-thiadiazol-3-yl)-1H-indoles (5a–l) were designed, synthesized and evaluated for anti-apoptotic Bcl-2-inhibitory activity. Synthesis of the target compounds was readily accomplished through a reaction of acyl hydrazide (1) with carbon disulfide in the presence of alcoholic potassium hydroxide to afford the corresponding intermediate potassium thiocarbamate salt (2), which underwent cyclization reaction in the presence of excess hydrazine hydrate to the corresponding triazole thiol (3). Further cyclisation reaction with substituted benzoyl chloride derivatives in the presence of phosphorous oxychloride afforded the final 6-phenyl-indol-3-yl [1,2,4]-triazolo[3,4-b]-[1,3,4]-thiadiazole compounds (5a–l). The novel series showed selective sub-micromolar IC50 growth-inhibitory activity against Bcl-2-expressing human cancer cell lines. The most potent 6-(2,4-dimethoxyphenyl) substituted analogue (5k) showed selective IC50 values of 0.31–0.7 µM against Bcl-2-expressing cell lines without inhibiting the Bcl-2-negative cell line (Jurkat). ELISA binding affinity assay (interruption of Bcl-2-Bim interaction) showed potent binding affinity for (5k) with an IC50 value of 0.32 µM. Moreover, it fulfils drug likeness criteria as a promising drug candidate.

Histone Deacetylase Inhibitory Activity of Peanut Testa Extracts against Human Cancer Cell Lines

2015 ◽  
Vol 39 (3) ◽  
pp. 263-273 ◽  
Author(s):  
Somprasong Khaopha ◽  
Sanun Jogloy ◽  
Aran Patanothai ◽  
Thanaset Senawong
Keyword(s):  
Histone Deacetylase ◽  
Cell Lines ◽  
Cancer Cell ◽  
Inhibitory Activity ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

ChemInform Abstract: Design and Synthesis of C35-Fluorinated Solamins and Their Growth Inhibitory Activities Against Human Cancer Cell Lines.

ChemInform ◽  
2012 ◽  
Vol 43 (9) ◽  
pp. no-no
Author(s):  
Naoto Kojima ◽  
Yuki Suga ◽  
Hiromi Hayashi ◽  
Takao Yamori ◽  
Takehiko Yoshimitsu ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Design And Synthesis ◽  
Growth Inhibitory ◽  
Inhibitory Activities

No Correlation between GSH Levels in Human Cancer Cell Lines and the Cell Growth Inhibitory Activities of Platinum Diamine Complexes

2004 ◽  
Vol 337 (12) ◽  
pp. 668-671 ◽  
Author(s):  
Boubakari ◽  
Karin Bracht ◽  
Christian Neumann ◽  
Renate Grünert ◽  
Patrick J. Bednarski
Keyword(s):  
Cell Growth ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Growth Inhibitory ◽  
Inhibitory Activities
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