Construction of a biotin-targeting drug delivery system and its near-infrared theranostic fluorescent probe for real-time image-guided therapy of lung cancer

2021 ◽  
Author(s):  
Xinyu Song ◽  
Rui Wang ◽  
Junfang Gao ◽  
Xiaoyue Han ◽  
Jianfeng Jin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Real Time ◽  
Fluorescent Probe ◽  
Drug Delivery System ◽  
Near Infrared ◽  
Image Guided ◽  
Real Time Image ◽  
Time Image ◽  
Guided Therapy

scholarly journals Hands-free, wireless goggles for near-infrared fluorescence and real-time image-guided surgery

Surgery ◽  
2011 ◽  
Vol 149 (5) ◽  
pp. 689-698 ◽  
Author(s):  
Yang Liu ◽  
Adam Q. Bauer ◽  
Walter J. Akers ◽  
Gail Sudlow ◽  
Kexian Liang ◽  
...  
Keyword(s):  
Real Time ◽  
Near Infrared ◽  
Image Guided Surgery ◽  
Near Infrared Fluorescence ◽  
Guided Surgery ◽  
Image Guided ◽  
Real Time Image ◽  
Time Image

Real-time imaging of alkaline phosphatase activity of diabetes in mice via a near-infrared fluorescent probe

2021 ◽  
Author(s):  
Wen-Xin Wang ◽  
Wen-Li Jiang ◽  
Hong Guo ◽  
Yongfei Li ◽  
Chun-Yan Li
Keyword(s):  
Alkaline Phosphatase ◽  
Real Time ◽  
Fluorescent Probe ◽  
Alkaline Phosphatase Activity ◽  
Near Infrared ◽  
Water Soluble ◽  
Alp Activity ◽  
Diabetes In Mice ◽  
Real Time Image ◽  
Time Image

A novel water-soluble near-infrared fluorescent probe named QX-P with simple synthesis is developed for detecting ALP. The probe can not only visualize ALP activity in four cell lines, but also real-time image ALP activity of diabetes in mice.

397 Intra-tumor immunotherapy injections utilizing image guidance in interventional radiology: clinical trial experience at a tertiary care cancer center

2020 ◽  
Vol 8 (Suppl 3) ◽  
pp. A422-A422
Author(s):  
Ravi Murthy ◽  
Rahul Sheth ◽  
Alda Tam ◽  
Sanjay Gupta ◽  
Vivek Subbiah ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Interventional Radiology ◽  
Real Time ◽  
Image Guidance ◽  
Tertiary Care ◽  
Cancer Center ◽  
Imaging Guidance ◽  
Image Guided ◽  
Real Time Image ◽  
Time Image

BackgroundImage guided intra-tumor administration of investigational immunotherapeutic agents represents an expanding field of interest. We present a retrospective review of the safety, feasibility & technical nuances of real-time image guidance for injection & biopsy across a spectrum of extracranial solid malignancies utilizing the discipline of Interventional Radiology.MethodsPatients who were enrolled in image guided intratumoral immunotherapy injection (ITITI) clinical trials over a 6 year period (2013–19) at a single tertiary care cancer center were included in this analysis. Malignancy, location, imaging guidance utilized for ITITI & biopsy for injected (adscopal) & non-injected (abscopal) lesions were determined and categorized. Peri-procedural adverse events were noted.Results262 pts (146 female, 61 yrs median) participating in 29 immunotherapeutic clinical trials (TLR & STING agonists, gene therapy, anti CD-40, viral/bacterial/metabolic oncolytics) met study criteria. Malignancies included melanoma 88, sarcoma 32, colorectal 29, breast 23, lung 17, head & neck 15, ovarian 8, neuroendocrine 7, pancreatic adenocarcinoma 6, 3 each (cholangioCA, endometrial, bladder, GI tract), 2 each (RCC, thymicCA, lymphoma, merkel cell, prostate) & others 1 each (CUP, GIST, dermatofibrosarcoma, DSRT, neuroblastoma, thyroid). All 169 & 93 patients received the intended 1371 ITITI in parietal (abdominal/chest wall, extremity, neck, pelvis) or visceral (liver, lung, peritoneum, adrenal) locations respectively; 83 patients received lymph node injections within either location. Imaging guidance was US in 68% of the cohort (US 161, CT+US 19); CT was used in 30% (81) & MRI in 1 patient. Median diameter of the ITITI lesion was 32 mm (8–230 mm). Median volume of the ITITI therapeutic material/session was 2 ml (1–6.9 ml). Lesions were accessed using a coaxial technique. ITITI delivery needles used at operator preference & tailored to lesion characteristics were either a 21G/22G Chiba, 21G Profusion (Cook Medical), 22G Morrison (AprioMed), 25G hypodermic (BD) & 18G Quadrafuse (Rex Medical). 2840 core biopsies (>18G Tru-cut core, Mission, Bard Medical) were performed in 237 patients during 690 procedures; biopsy sessions were often concurrent & of the ITITI site. 137 patients also underwent biopsy of a non-ITITI site (89 parietal location). Dimensions of the non-ITITI lesion were median 10 mm (7–113 mm); US image guidance was used in 97 patients (72%) to obtain a total of 1257, >18G Tru-core samples. 1.3% of injections resulted in SAE (NCI CTC AE >3) and 0.5% of 4097 biopsies developed major complications (SIR Criteria); both categories were manageable.ConclusionsUtilizing real time image guidance, ITITI to the administration of a myriad of investigational immunotherapeutic agents with concomitant biopsy procedures to date are associated with a high technical success rate & favorable safety profile.AcknowledgementsJoshua Hein, Mara Castaneda, Jyotsna Pera, Yunfang Jiang,Shuang Liu, Holly Liu and Anna LuiTrial RegistrationN/AEthics ApprovalThe study was approved by Institution’s Ethics Board, approval number 2020-0536: A retrospective study to determine the safety, feasibility and technical challenges of real-time image guidance for intra-tumor injection and biopsy across multiple solid tumors.Consent2020-0536 Waiver of Informed ConsentReferenceSheth RA, Murthy R, Hong DS, et al. Assessment of image-guided intratumoral delivery of immunotherapeutics in patients with cancer. JAMA Netw Open 2020;3(7):e207911. doi:10.1001/jamanetworkopen.2020.7911

Imaging and visual analysis---Toward real-time image guided neurosurgery using distributed and grid computing

2006 ◽  
Author(s):  
Nikos Chrisochoides ◽  
Andriy Fedorov ◽  
Andriy Kot ◽  
Neculai Archip ◽  
Peter Black ◽  
...  
Keyword(s):  
Grid Computing ◽  
Real Time ◽  
Visual Analysis ◽  
Image Guided ◽  
Real Time Image ◽  
Time Image

PD-0488 ROUTINE REAL-TIME IMAGE-GUIDED VERIFICATION OF BREATH HOLD IN BREAST CANCER PATIENTS

2012 ◽  
Vol 103 ◽  
pp. S196
Author(s):  
H. de Boer ◽  
H.J.G. van den Bongard ◽  
W. de Kruijf ◽  
B. van Asselen
Keyword(s):  
Breast Cancer ◽  
Real Time ◽  
Cancer Patients ◽  
Breath Hold ◽  
Breast Cancer Patients ◽  
Image Guided ◽  
Real Time Image ◽  
Time Image

scholarly journals Machine Learning Based Real‐Time Image‐Guided Cell Sorting and Classification

2019 ◽  
Vol 95 (5) ◽  
pp. 499-509 ◽  
Author(s):  
Yi Gu ◽  
Alex Ce Zhang ◽  
Yuanyuan Han ◽  
Jie Li ◽  
Clark Chen ◽  
...  
Keyword(s):  
Machine Learning ◽  
Real Time ◽  
Cell Sorting ◽  
Image Guided ◽  
Real Time Image ◽  
Time Image

scholarly journals Real-time image-guided electromagnetic navigation bronchoscopy dual-marker technique to localize deep pulmonary nodules in a hybrid operating room

2020 ◽  
Vol 58 (Supplement_1) ◽  
pp. i103-i105
Author(s):  
Chuan Cheng ◽  
Hsin-Yueh Fang ◽  
Chih-Tsung Wen ◽  
Yin-Kai Chao
Keyword(s):  
Operating Room ◽  
Near Infrared ◽  
Pulmonary Nodules ◽  
Surface Marker ◽  
Hybrid Operating Room ◽  
Electromagnetic Navigation ◽  
Image Guided ◽  
Real Time Image ◽  
Near Infrared Dye ◽  
Time Image

Abstract Herein, we describe a Dyna-computed tomography-guided electromagnetic navigation bronchoscopy technique aimed at localizing deep pulmonary nodules. The method was implemented in a hybrid operating room and required the use of 2 markers (a near-infrared dye as a surface marker and a microcoil as a deep marker).

Robot-Assisted versus Freehand Instrumentation in Short-Segment Lumbar Fusion: Experience with Real-Time Image-Guided Spinal Robot

2020 ◽  
Vol 136 ◽  
pp. e635-e645 ◽  
Author(s):  
Bowen Jiang ◽  
Zach Pennington ◽  
Tej Azad ◽  
Ann Liu ◽  
A. Karim Ahmed ◽  
...  
Keyword(s):  
Real Time ◽  
Lumbar Fusion ◽  
Robot Assisted ◽  
Short Segment ◽  
Image Guided ◽  
Real Time Image ◽  
Time Image
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