Data on spectral, optical and mechanical properties of 2-aminopyridine potassium dihydrogen orthophosphate (2APKDP) crystal

2019 ◽  
Vol 23 ◽  
pp. 100264 ◽  
Author(s):  
D. Sivavishnu ◽  
R. Srineevasan ◽  
J. Johnson
Keyword(s):  
Mechanical Properties ◽  
Potassium Dihydrogen ◽  
Optical And Mechanical Properties ◽  
Potassium Dihydrogen Orthophosphate ◽  
Dihydrogen Orthophosphate

Structural Elucidation of Potential Impurities in Azilsartan Bulk Drug by HPLC

2014 ◽  
Vol 97 (6) ◽  
pp. 1552-1562
Author(s):  
Wentao Zhou ◽  
Yuxia Zhou ◽  
Lili Sun ◽  
Qiaogen Zou ◽  
Ping Wei ◽  
...  
Keyword(s):  
Phosphoric Acid ◽  
Correlation Coefficient ◽  
Chromatographic Method ◽  
Hplc Method ◽  
Potassium Dihydrogen ◽  
The Mean ◽  
Bulk Drug ◽  
Potassium Dihydrogen Orthophosphate ◽  
Gradient Mode ◽  
Dihydrogen Orthophosphate

Abstract During the synthesis of Azilsartan (AZS), it was speculated that 15 potential impurities would arise. This study investigated the possible mechanism for the formation of 14 of them, and their structures were characterized and confirmed by IR, NMR, and MS techniques. In addition, an efficient chromatographic method was developed to separate and quantify these impurities, using an Inertsil ODS-3 column (250 × 4.6 mm, 5 μm) in gradient mode with a mixture of acetonitrile and the potassium dihydrogen orthophosphate buffer (10 mM, pH adjusted to 3.0 with phosphoric acid). The HPLC method was validated for specificity, precision, accuracy, and sensitivity. LOQ of impurities were in the range of 1.04–2.20 ng. Correlation coefficient values of linearity were >0.9996 for AZS and its impurities. The mean recoveries of all impurities in AZS were between 93.0 and 109.7%. Thus, the validated HPLC method is suitable for the separation and quantification of all potential impurities in AZS.

Effects of fertilizer on concentrations of copper, molybdenum, and sulfur in subterrranean clover (Trifolium subterraneum)

1981 ◽  
Vol 21 (112) ◽  
pp. 491 ◽  
Author(s):  
GD Reddy ◽  
AM Alston ◽  
KG Tiller
Keyword(s):  
Animal Health ◽  
Sodium Molybdate ◽  
Subterranean Clover ◽  
Trifolium Subterraneum ◽  
Dry Weight ◽  
Calcareous Sand ◽  
Potassium Dihydrogen ◽  
Podzolic Soils ◽  
Potassium Dihydrogen Orthophosphate ◽  
Dihydrogen Orthophosphate

In pot experiments, subterranean clover (Trifolium subterraneum) was grown on four soils; two lateritic podzolic soils, a red-brown earth and a calcareous sand, to which various combinations of phosphorus (0 to 45 ppm as potassium dihydrogen orthophosphate), sulfur (0 to 45 ppm as calcium sulfate), copper (0 to 10 ppm as copper sulphate) and molybdenum (0 to 1 ppm as sodium molybdate) had been added. Applications of sulfur and copper had little effect on the dry weight of the clover tops on any soil, and none of the fertilizers affected dry weight on the calcareous sand. On the other soils, dry weight was increased by phosphorus, and by molybdenum when applied in combination with phosphorus. The copper treatment consistently increased the concentration of that element in the tops of the plants. On the lateritic podzolic soils and the red-brown earth, sulfur generally increased copper and sulfur concentrations but decreased that of molybdenum; phosphorus decreased copper and sulfur but increased the concentration of molybdenum. On the calcareous sand, application of sulfur had no effect on copper but decreased molybdenum and increased sulfur concentration; treatment with phosphorus decreased the concentration of copper but had no effect on sulfur or molybdenum in the plant tops. There were significant interactions between all treatments. These are discussed in relation to fertilizer practice and animal health.

Optimizing the medium components in bioemulsifiers production byCandida lipolyticawith response surface method

2006 ◽  
Vol 52 (6) ◽  
pp. 575-583 ◽  
Author(s):  
C D.C Albuquerque ◽  
A M.F Filetti ◽  
G M Campos-Takaki
Keyword(s):  
Response Surface Methodology ◽  
Central Composite Design ◽  
Response Surface ◽  
Ammonium Sulfate ◽  
Corn Oil ◽  
Potassium Dihydrogen ◽  
Emulsification Activity ◽  
Potassium Dihydrogen Orthophosphate ◽  
Central Composite ◽  
Dihydrogen Orthophosphate

A response surface methodology was used to study bioemulsifier production by Candida lipolytica. A 24full experimental design was previously carried out to investigate the effects and interactions of the concentrations of corn oil, urea, ammonium sulfate, and potassium dihydrogen orthophosphate on the emulsification activity (EA) of the bioemulsifier produced by C. lipolytica. The best EA value (3.727 units of emulsification activity (UEA)) was obtained with a medium composed of 0.4 g of urea, 1.1 g of ammonium sulfate, 2.04 g of potassium dihydrogen orthophosphate, 5 mL of corn oil, 50 mL of distilled water, and 50 mL of seawater. A curvature check was performed and revealed a lack of fit of the linear approximation. The proximity of the optimum point was evident, as was the need for quadratic model and second-order designs that incorporate the effect of the curvature. Medium constituents were then optimized for the EA using a three-factor central composite design and response surface methodology. The second-order model showed statistical significance and predictive ability. It was found that the maximum EA produced was 4.415 UEA, and the optimum levels of urea, ammonium sulfate, and potassium dihydrogen orthophosphate were, respectively, 0.544% (m/v), 2.131% (m/v), and 2.628% (m/v).Key words: emulsification activity, factorial design, central composite design, optimization, biosurfactant.

Thermodynamics of aqueous sodium and potassium dihydrogen orthophosphate solutions at 25°C

1973 ◽  
Vol 26 (4) ◽  
pp. 863 ◽  
Author(s):  
CW Childs ◽  
CJ Downes ◽  
RF Platford
Keyword(s):  
Sodium Salt ◽  
Potassium Salt ◽  
Osmotic Coefficients ◽  
Isopiestic Method ◽  
Potassium Dihydrogen ◽  
Aqueous Sodium ◽  
Low Concentrations ◽  
Potassium Dihydrogen Orthophosphate ◽  
Sodium And Potassium ◽  
Dihydrogen Orthophosphate

The osmotic coefficients of aqueous NaH2PO4 and aqueous KH2PO4 over the ranges 1.0-6.5 mol kg-1 for the sodium salt and 0.85-2.2 mol kg-1 for the potassium salt were determined at 25�C by the isopiestic method. Our data were combined with the data of Scatchard and Breckenridge for low concentrations in order to calculate smooth values of osmotic and activity coefficients for concentrations down to 0.1 mol kg-1.

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