Process intensification of a photochemical oxidation reaction using a Rotor-Stator Spinning Disk Reactor: A strategy for scale up

<div>This paper presents a novel high-throughput reactor for intensification of photochemical conversion processes. The photocatalyzed gas-liquid oxidation of α-terpinene to the drug ascaridole with rose-bengal was achieved with throughputs of over 1 kg∙day-1 (71 kg∙day-1∙m-2) under visible light irradiation. The performance of the reactor is correlated to rotation speed, liquid flowrate, gas flowrate, catalyst concentration, substrate concentration, gas holdup, gas bubble size, and energy dissipation rate. The conversion and selectivity increase from 37% to 97% and 75% to 90% respectively with an increase of rotation speed from 100 to 2000 RPM. Compared to conventional photochemical reactors such as the batch reactor or the microreactor, the photo-rotor-stator spinning disk reactor has much higher productivity (270 mmol∙h-1 or 19.2 mol∙h-1∙m-2) and higher selectivity (> 90%), with the latter illustrating the impact of mixing on selectivity. The findings of this study can be used to study, design, optimize and scale photochemical processes using the rotor-stator spinning disk reactor.</div>

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Process Intensification of Photochemical Oxidations using a High Throughput Rotor-Stator Spinning Disk Reactor: A Strategy for Scale Up

10.26434/chemrxiv.11560224.v1 ◽

2020 ◽

Cited By ~ 3

Author(s):

Arnab Chaudhuri ◽

Koen P. L. Kuijpers ◽

Raoul Hendrix ◽

Jasper Hacking ◽

Parimala Shivaprasad ◽

...

Keyword(s):

High Throughput ◽

Dissipation Rate ◽

Catalyst Concentration ◽

Rotation Speed ◽

Batch Reactor ◽

Scale Up ◽

Process Intensification ◽

Energy Dissipation Rate ◽

Spinning Disk ◽

The Impact

<div>This paper presents a novel high-throughput reactor for intensification of photochemical conversion processes. The photocatalyzed gas-liquid oxidation of α-terpinene to the drug ascaridole with rose-bengal was achieved with throughputs of over 1 kg∙day-1 (71 kg∙day-1∙m-2) under visible light irradiation. The performance of the reactor is correlated to rotation speed, liquid flowrate, gas flowrate, catalyst concentration, substrate concentration, gas holdup, gas bubble size, and energy dissipation rate. The conversion and selectivity increase from 37% to 97% and 75% to 90% respectively with an increase of rotation speed from 100 to 2000 RPM. Compared to conventional photochemical reactors such as the batch reactor or the microreactor, the photo-rotor-stator spinning disk reactor has much higher productivity (270 mmol∙h-1 or 19.2 mol∙h-1∙m-2) and higher selectivity (> 90%), with the latter illustrating the impact of mixing on selectivity. The findings of this study can be used to study, design, optimize and scale photochemical processes using the rotor-stator spinning disk reactor.</div>

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Purification of alkaloids from Catharanthus roseus by pH-zone refining centrifugal partition chromatography: process intensification and scale up

Planta Medica ◽

10.1055/s-0036-1596139 ◽

2016 ◽

Vol 81 (S 01) ◽

pp. S1-S381

Author(s):

S Chollet ◽

A Kotland ◽

JM Autret ◽

G Calmels ◽

C Diard ◽

...

Keyword(s):

Catharanthus Roseus ◽

Scale Up ◽

Process Intensification ◽

Partition Chromatography ◽

Centrifugal Partition Chromatography ◽

Zone Refining

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Purification of alkaloids from Catharanthus roseus by pH-Zone Refining Centrifugal Partition Chromatography: process intensification and scale up

10.1055/s-0037-1608276 ◽

2017 ◽

Author(s):

A Kotland ◽

S Chollet ◽

JM Autret ◽

G Calmels ◽

C Diard ◽

...

Keyword(s):

Catharanthus Roseus ◽

Scale Up ◽

Process Intensification ◽

Partition Chromatography ◽

Centrifugal Partition Chromatography ◽

Zone Refining

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Application of Microfluidics in Process Intensification

International Journal of Chemical Reactor Engineering ◽

10.1515/ijcre-2018-0038 ◽

2018 ◽

Vol 16 (12) ◽

Cited By ~ 1

Author(s):

Harrson S. Santana ◽

Mariana G. M. Lopes ◽

João L. Silva ◽

Osvaldir P. Taranto

Keyword(s):

Scale Up ◽

Production Capacity ◽

Process Intensification ◽

Plant Size ◽

Chemical Plant ◽

Sustainable Operations ◽

Production Techniques ◽

Equipment Size ◽

System Miniaturization

Abstract Is it possible to miniaturize a chemical plant? Some strategies, such as the process intensification, sustain that the advancements in equipment and production techniques could substantially decrease the equipment size/production capacity ratio, energy consumption and waste generation, resulting in more economic and sustainable operations and consequently reducing the chemical plant size. However, large reductions of equipment volume represent a major challenge for the conventional technologies. In this context, Microfluidics represents a promising technology in the field of system miniaturization. Accordingly, the present research evaluated the concept of process intensification and its relationship with Microfluidics. Initially, the definition and the classification of process intensification were described, following by the explanation of the Microfluidics, highlighting scale-up strategies and examples using miniaturized systems. Afterward, a methodology for miniaturized devices development for process intensification using numerical simulations was shown. Finally, the conclusions are exposed.

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Scale-up of Process Intensifying Falling Film Microreactors to Pilot Production Scale

International Journal of Chemical Reactor Engineering ◽

10.2202/1542-6580.1463 ◽

2007 ◽

Vol 5 (1) ◽

Cited By ~ 17

Author(s):

Bhanu Kiran Vankayala ◽

Patrick Löb ◽

Volker Hessel ◽

Gabriele Menges ◽

Christian Hofmann ◽

...

Keyword(s):

Sodium Hydroxide Solution ◽

Ambient Pressure ◽

Scale Up ◽

Process Intensification ◽

Aqueous Sodium Hydroxide ◽

Liquid Films ◽

Process Conditions ◽

Falling Film ◽

Production Scale ◽

Future Production

Microstructured reactors with their benefits especially concerning enhanced mass and heat transfer represent a means for process intensification. A broadly used microstructured lab tool in the area of gas/liquid contacting is the Falling Film Microreactor (FFMR) developed by IMM in which liquid films of a few tens of micrometer thickness and interfacial areas of up to 20,000 m2/m3 combined with an effective heat exchange can be obtained. Now the concept of the Falling Film Microreactor has been developed further with regard to increasing throughput in order to reach pilot production level and as a basis for future production scale throughput. Therefore, two different prototypes with a tenfold larger structured surface area have been developed and realized. The feasibility of a corresponding increase of throughput has been demonstrated for the oxidation of an organic compound using oxygen which is closely linked to an industrial relevant reaction and additionally by the absorption of CO2 in an aqueous sodium hydroxide solution. Naturally, process optimisation itself also contributes to the efforts to increase throughput. Therefore, the oxidation reaction has been optimised in both varying process parameters (temperature, flow rates, pressure) and reactor parameters (microchannel width and depth) in the original, standard Falling Film Microreactor. Conducting experiments at 10 bar instead of ambient pressure and using a reaction plate with 1200 µm x 400 µm channels instead of 600 µm x 200 µm channels lead to an increase in conversion. These investigations also encourage exploring more challenging process conditions and thereby following the concept of "novel chemistry."

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