Oxygen releasing and antioxidant breathing cardiac patch delivering exosomes promotes heart repair after myocardial infarction

2021 ◽  
pp. 132490
Author(s):  
Parvaiz Ahmad Shiekh ◽  
Soheb Anwar Mohammed ◽  
Sneha Gupta ◽  
Ankita Das ◽  
Himanshu Meghwani ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Repair ◽  
Cardiac Patch

scholarly journals Heart Repair Using Nanogel-Encapsulated Human Cardiac Stem Cells in Mice and Pigs with Myocardial Infarction

ACS Nano ◽  
2017 ◽  
Vol 11 (10) ◽  
pp. 9738-9749 ◽  
Author(s):  
Junnan Tang ◽  
Xiaolin Cui ◽  
Thomas G. Caranasos ◽  
M. Taylor Hensley ◽  
Adam C. Vandergriff ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Cardiac Stem Cells ◽  
Heart Repair

scholarly journals Recent fabrications and applications of cardiac patch in myocardial infarction treatment

View ◽  
2021 ◽  
pp. 20200153
Author(s):  
Mei Li ◽  
Hao Wu ◽  
Yuehui Yuan ◽  
Benhui Hu ◽  
Ning Gu
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Patch

scholarly journals Cardiac cell–integrated microneedle patch for treating myocardial infarction

2018 ◽  
Vol 4 (11) ◽  
pp. eaat9365 ◽  
Author(s):  
Junnan Tang ◽  
Jinqiang Wang ◽  
Ke Huang ◽  
Yanqi Ye ◽  
Teng Su ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stromal Cells ◽  
Heart Regeneration ◽  
Patch Application ◽  
Model Study ◽  
Heart Repair ◽  
Injured Myocardium ◽  
Cardiac Functions ◽  
Microneedle Patch ◽  
Host Myocardium

We engineered a microneedle patch integrated with cardiac stromal cells (MN-CSCs) for therapeutic heart regeneration after acute myocardial infarction (MI). To perform cell-based heart regeneration, cells are currently delivered to the heart via direct muscle injection, intravascular infusion, or transplantation of epicardial patches. The first two approaches suffer from poor cell retention, while epicardial patches integrate slowly with host myocardium. Here, we used polymeric MNs to create “channels” between host myocardium and therapeutic CSCs. These channels allow regenerative factors secreted by CSCs to be released into the injured myocardium to promote heart repair. In the rat MI model study, the application of the MN-CSC patch effectively augmented cardiac functions and enhanced angiomyogenesis. In the porcine MI model study, MN-CSC patch application was nontoxic and resulted in cardiac function protection. The MN system represents an innovative approach delivering therapeutic cells for heart regeneration.

scholarly journals 4D physiologically adaptable cardiac patch: A 4-month in vivo study for the treatment of myocardial infarction

2020 ◽  
Vol 6 (26) ◽  
pp. eabb5067 ◽  
Author(s):  
Haitao Cui ◽  
Chengyu Liu ◽  
Timothy Esworthy ◽  
Yimin Huang ◽  
Zu-xi Yu ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Treatment Method ◽  
Biomechanical Properties ◽  
Vascular Supply ◽  
Cardiac Tissues ◽  
Cell Engraftment ◽  
Organ Regeneration ◽  
Cardiac Patch

There has been considerable progress in engineering cardiac scaffolds for the treatment of myocardial infarction (MI). However, it is still challenging to replicate the structural specificity and variability of cardiac tissues using traditional bioengineering approaches. In this study, a four-dimensional (4D) cardiac patch with physiological adaptability has been printed by beam-scanning stereolithography. By combining a unique 4D self-morphing capacity with expandable microstructure, the specific design has been shown to improve both the biomechanical properties of the patches themselves and the dynamic integration of the patch with the beating heart. Our results demonstrate improved vascularization and cardiomyocyte maturation in vitro under physiologically relevant mechanical stimulation, as well as increased cell engraftment and vascular supply in a murine chronic MI model. This work not only potentially provides an effective treatment method for MI but also contributes a cutting-edge methodology to enhance the structural design of complex tissues for organ regeneration.

scholarly journals An Elastic, Biodegradable Cardiac Patch Induces Contractile Smooth Muscle and Improves Cardiac Remodeling and Function in Subacute Myocardial Infarction

2007 ◽  
Vol 49 (23) ◽  
pp. 2292-2300 ◽  
Author(s):  
Kazuro L. Fujimoto ◽  
Kimimasa Tobita ◽  
W. David Merryman ◽  
Jianjun Guan ◽  
Nobuo Momoi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Smooth Muscle ◽  
Cardiac Remodeling ◽  
And Function ◽  
Cardiac Patch

scholarly journals Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Ienglam Lei ◽  
Shuo Tian ◽  
Wenbin Gao ◽  
Liu Liu ◽  
Yijing Guo ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Histone Acetylation ◽  
Heart Function ◽  
Ischemia Reperfusion ◽  
Carbon Sources ◽  
Metabolic Enzyme ◽  
Acetyl Coa ◽  
Antioxidant Genes ◽  
Heart Repair ◽  
Energy Deprivation

Myocardial infarction (MI) is accompanied by severe energy deprivation and extensive epigenetic changes. However, how energy metabolism and chromatin modifications are interlinked during MI and heart repair has been poorly explored. Here, we examined the effect of different carbon sources that are involved in the major metabolic pathways of acetyl-CoA synthesis on myocardial infarction and found that elevation of acetyl-CoA by sodium octanoate (8C) significantly improved heart function in ischemia reperfusion (I/R) rats. Mechanistically, 8C reduced I/R injury by promoting histone acetylation which in turn activated the expression of antioxidant genes and inhibited cardiomyocyte (CM) apoptosis. Furthermore, we elucidated that 8C-promoted histone acetylation and heart repair were carried out by metabolic enzyme medium-chain acyl-CoA dehydrogenase (MCAD) and histone acetyltransferase Kat2a, suggesting that 8C dramatically improves cardiac function mainly through metabolic acetyl-CoA-mediated histone acetylation. Therefore, our study uncovers an interlinked metabolic/epigenetic network comprising 8C, acetyl-CoA, MCAD, and Kat2a to combat heart injury.

scholarly journals Innate Lymphoid Cells and Myocardial Infarction

2021 ◽  
Vol 12 ◽  
Author(s):  
Wenling Yang ◽  
Jibin Lin ◽  
Jin Zhou ◽  
Yuqi Zheng ◽  
Shijiu Jiang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
High Morbidity ◽  
Human Immune System ◽  
Treatment And Prevention ◽  
Heart Repair ◽  
Myocardial Ischemia Reperfusion

Myocardial infarction results from obstruction of a coronary artery that causes insufficient blood supply to the myocardium and leads to ischemic necrosis. It is one of the most common diseases threatening human health and is characterized by high morbidity and mortality. Atherosclerosis is the pathological basis of myocardial infarction, and its pathogenesis has not been fully elucidated. Innate lymphoid cells (ILCs) are an important part of the human immune system and participate in many processes, including inflammation, metabolism and tissue remodeling, and play an important role in atherosclerosis. However, their specific roles in myocardial infarction are unclear. This review describes the current understanding of the relationship between innate lymphoid cells and myocardial infarction during the acute phase of myocardial infarction, myocardial ischemia-reperfusion injury, and heart repair and regeneration following myocardial infarction. We suggest that this review may provide new potential intervention targets and ideas for treatment and prevention of myocardial infarction.

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