BDNF signaling in context: From synaptic regulation to psychiatric disorders

Cell ◽  
2021 ◽  
Author(s):  
Camille S. Wang ◽  
Ege T. Kavalali ◽  
Lisa M. Monteggia
Keyword(s):  
Psychiatric Disorders ◽  
Synaptic Regulation ◽  
Bdnf Signaling

scholarly journals Psychiatric Disorders and lncRNAs: A Synaptic Match

2020 ◽  
Vol 21 (9) ◽  
pp. 3030 ◽  
Author(s):  
Francesco Rusconi ◽  
Elena Battaglioli ◽  
Marco Venturin
Keyword(s):  
Psychiatric Disorders ◽  
Behavioral Adaptation ◽  
Control Mechanisms ◽  
Synaptic Regulation ◽  
Epigenetic Modifiers ◽  
Mental Diseases ◽  
Psychiatric Conditions ◽  
Non Coding Rnas ◽  
Synaptic Control ◽  
Heterogeneous Class

Psychiatric disorders represent a heterogeneous class of multifactorial mental diseases whose origin entails a pathogenic integration of genetic and environmental influences. Incidence of these pathologies is dangerously high, as more than 20% of the Western population is affected. Despite the diverse origins of specific molecular dysfunctions, these pathologies entail disruption of fine synaptic regulation, which is fundamental to behavioral adaptation to the environment. The synapses, as functional units of cognition, represent major evolutionary targets. Consistently, fine synaptic tuning occurs at several levels, involving a novel class of molecular regulators known as long non-coding RNAs (lncRNAs). Non-coding RNAs operate mainly in mammals as epigenetic modifiers and enhancers of proteome diversity. The prominent evolutionary expansion of the gene number of lncRNAs in mammals, particularly in primates and humans, and their preferential neuronal expression does represent a driving force that enhanced the layering of synaptic control mechanisms. In the last few years, remarkable alterations of the expression of lncRNAs have been reported in psychiatric conditions such as schizophrenia, autism, and depression, suggesting unprecedented mechanistic insights into disruption of fine synaptic tuning underlying severe behavioral manifestations of psychosis. In this review, we integrate literature data from rodent pathological models and human evidence that proposes the biology of lncRNAs as a promising field of neuropsychiatric investigation.

What's in a model? Network models as tools instead of representations of what psychiatric disorders really are

2019 ◽  
Vol 42 ◽  
Author(s):  
Hanna M. van Loo ◽  
Jan-Willem Romeijn
Keyword(s):  
Psychiatric Disorders ◽  
Network Models ◽  
Model Network

AbstractNetwork models block reductionism about psychiatric disorders only if models are interpreted in a realist manner – that is, taken to represent “what psychiatric disorders really are.” A flexible and more instrumentalist view of models is needed to improve our understanding of the heterogeneity and multifactorial character of psychiatric disorders.

Applications of RTMS in psychiatric disorders

1997 ◽  
Vol 103 (1) ◽  
pp. 49
Author(s):  
E Wassermann
Keyword(s):  
Psychiatric Disorders

Psychiatric Disorders Inherited Separately From Atopy

2005 ◽  
Vol 36 (2) ◽  
pp. 63
Author(s):  
DAMIAN MCNAMARA
Keyword(s):  
Psychiatric Disorders

Suicide in Nógrád County, Hungary, 1970-1994

Crisis ◽  
1999 ◽  
Vol 20 (2) ◽  
pp. 64-70 ◽  
Author(s):  
Tamás Zonda
Keyword(s):  
High Risk ◽  
Psychiatric Disorders ◽  
Suicide Rate ◽  
Risk Groups ◽  
The Elderly ◽  
Female Ratio ◽  
Suicide Notes ◽  
Suicidal Intention ◽  
Male Female Ratio

The author examined completed suicides occurring over a period of 25 years in a county of Hungary with a traditionally low (relatively speaking) suicide rate of 25.8. The rates are clearly higher in villages than in the towns. The male/female ratio was close to 4:1, among elderly though only 1.5:1. The high risk groups are the elderly, divorced, and widowed. Violent methods are chosen in 66.4% of the cases. The rates are particularly high in the period April-July. Prior communication of suicidal intention was revealed in 16.3% of all cases. Previous attempts had been undertaken by 17%, which in turn means that 83% of suicides were first attempts. In our material 10% the victims left suicide notes. Psychiatric disorders were present in 60.1% of the cases, and severe, multiple somatic illnesses (including malignomas) were present in 8.8%. The majority of the data resemble those found in the literature.

Sati

Crisis ◽  
2005 ◽  
Vol 26 (2) ◽  
pp. 73-77 ◽  
Author(s):  
Dinesh Bhugra
Keyword(s):  
Mental Illness ◽  
Psychiatric Disorders ◽  
Indian Subcontinent ◽  
Cultural Factors ◽  
Role Expectations ◽  
Prevention Strategies ◽  
Social Causation ◽  
Gender Role Expectations ◽  
Good Wife ◽  
And Gender

Abstract. Sati as an act of ritual suicide has been reported from the Indian subcontinent, especially among the Hindus, for several centuries. Although legally proscribed, these acts occur even now in modern India. The principle behind such acts has been put forward as the principle of good wife. There is little evidence to suggest that women who commit this act suffer from a formal mental illness. Cultural factors and gender role expectations play a significant role in the act and its consequences. Using recent examples, this paper illustrates the cultural factors, which may be seen as contributing to the act of suicide. Other factors embedded in the act also emphasize that not all suicides have underlying psychiatric disorders and clinicians must take social causation into account while preparing any prevention strategies.

Review of Biological bases of psychiatric disorders.

1978 ◽  
Vol 23 (10) ◽  
pp. 777-777
Author(s):  
RICHARD F. THOMPSON
Keyword(s):  
Psychiatric Disorders

A Comprehensive Update on Etiology and Prevention of a Selection of Major Psychiatric Disorders

PsycCRITIQUES ◽  
2008 ◽  
Vol 53 (5) ◽  
Author(s):  
Lynn H. Collins
Keyword(s):  
Psychiatric Disorders ◽  
Selection Of
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