FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

Human Pulmonary Artery ◽

Androgen Independent

Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells

Oncotarget ◽

10.18632/oncotarget.7693 ◽

2016 ◽

Vol 7 (13) ◽

pp. 16663-16675 ◽

Cited By ~ 49

Author(s):

Melissa McNaughton ◽

Melissa Pitman ◽

Stuart M. Pitson ◽

Nigel J. Pyne ◽

Susan Pyne

Keyword(s):

Prostate Cancer ◽

Cancer Cells ◽

Kinase Inhibitors ◽

Growth Arrest ◽

Sphingosine Kinase ◽

Proteasomal Degradation ◽

Sphingosine Kinase 1 ◽

Prostate Cancer Cells ◽

Dihydroceramide Desaturase ◽

Androgen Independent

Brain Derived Neurotrophic Factor In Proliferation Of Human Pulmonary Artery Smooth Muscle

10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3449 ◽

2011 ◽

Author(s):

William R. Hartman ◽

Farah Yusuf ◽

Lucas W. Meuchel ◽

Christina M. Pabelick ◽

Y S Prakash

Keyword(s):

Smooth Muscle ◽

Pulmonary Artery ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Selective biological response of human pulmonary microvascular endothelial cells and human pulmonary artery smooth muscle cells on cold-plasma-modified polyester vascular prostheses

Biomedical Materials ◽

10.1088/1748-6041/6/6/065003 ◽

2011 ◽

Vol 6 (6) ◽

pp. 065003 ◽

Cited By ~ 8

Author(s):

N Blanchemain ◽

M R Aguilar ◽

F Chai ◽

M Jimenez ◽

E Jean-Baptiste ◽

...

Keyword(s):

Endothelial Cells ◽

Smooth Muscle ◽

Pulmonary Artery ◽

Smooth Muscle Cells ◽

Cold Plasma ◽

Biological Response ◽

Microvascular Endothelial Cells ◽

Vascular Prostheses ◽

Brain Derived Neurotrophic Factor Prevents Apoptosis In Human Pulmonary Artery Smooth Muscle Cells

10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3400 ◽

2012 ◽

Author(s):

William R. Hartman ◽

Lucas W. Meuchel ◽

Dan F. Smelter ◽

Michael A. Thompson ◽

Christina M. Pabelick ◽

...

Keyword(s):

Smooth Muscle ◽

Pulmonary Artery ◽

Smooth Muscle Cells ◽

Neurotrophic Factor ◽

Muscle Cells ◽

Brain Derived Neurotrophic Factor ◽

Fenfluramine-Induced Gene Dysregulation in Human Pulmonary Artery Smooth Muscle and Endothelial Cells

Pulmonary Circulation ◽

10.4103/2045-8932.87310 ◽

2011 ◽

Vol 1 (3) ◽

pp. 405-418 ◽

Cited By ~ 5

Author(s):

Weijuan Yao ◽

Wenbo Mu ◽

Amy Zeifman ◽

Michelle Lofti ◽

Carmelle V. Remillard ◽

...

Keyword(s):

Endothelial Cells ◽

Smooth Muscle ◽

Pulmonary Artery ◽

Gene Dysregulation ◽

Cyclooxygenase-2 Acts as an Endogenous Brake on Endothelin-1 Release by Human Pulmonary Artery Smooth Muscle Cells: Implications for Pulmonary Hypertension

Molecular Pharmacology ◽

10.1124/mol.62.5.1147 ◽

2002 ◽

Vol 62 (5) ◽

pp. 1147-1153 ◽

Cited By ~ 21

Author(s):

Stephen J. Wort ◽

Mandy Woods ◽

Timothy D. Warner ◽

Timothy W. Evans ◽

Jane A. Mitchell

Keyword(s):

Pulmonary Hypertension ◽

Smooth Muscle ◽

Pulmonary Artery ◽

Smooth Muscle Cells ◽

Muscle Cells ◽

Cyclooxygenase 2 ◽

Endothelin 1 ◽

S36 Ferroportin Is Expressed In Human Pulmonary Artery Smooth Muscle Cells: Implications For Pulmonary Arterial Hypertension

Thorax ◽

10.1136/thoraxjnl-2014-206260.42 ◽

2014 ◽

Vol 69 (Suppl 2) ◽

pp. A21-A21 ◽

Cited By ~ 1

Author(s):

L. Ramakrishnan ◽

S. Mumby ◽

J. Wort ◽

G. Quinlan

Keyword(s):

Smooth Muscle ◽

Pulmonary Arterial Hypertension ◽

Pulmonary Artery ◽

Arterial Hypertension ◽

Smooth Muscle Cells ◽

Muscle Cells ◽

Pulmonary Arterial ◽

Protein kinase A (PKA) and exchange protein directly activated by cAMP (Epac) in human pulmonary artery smooth muscle cells: expression, function and downstream signaling

The FASEB Journal ◽

10.1096/fasebj.24.1_supplement.1023.23 ◽

2010 ◽

Vol 24 (S1) ◽

Author(s):

Ohmin Kwon ◽

Fiona Murray ◽

Paul A. Insel

Keyword(s):

Smooth Muscle ◽

Protein Kinase ◽

Pulmonary Artery ◽

Smooth Muscle Cells ◽

Protein Kinase A ◽

Muscle Cells ◽

Downstream Signaling ◽

Human Pulmonary Artery ◽

Kinase A

Upregulation of thioredoxin and its reductase attenuates arsenic trioxide‑induced growth suppression in human pulmonary artery smooth muscle cells by reducing oxidative stress

Oncology Reports ◽

10.3892/or.2019.7414 ◽

2019 ◽

Author(s):

Woo Park

Keyword(s):

Oxidative Stress ◽

Smooth Muscle ◽

Pulmonary Artery ◽

Smooth Muscle Cells ◽

Arsenic Trioxide ◽

Muscle Cells ◽

Growth Suppression ◽

Immunosuppressive drug FTY720 sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase‐1.

The FASEB Journal ◽

10.1096/fasebj.22.1_supplement.805.1 ◽

2008 ◽

Vol 22 (S1) ◽

Author(s):

Dmitry Pshezhetskiy ◽

Torsten Bohler ◽

Nicolas Doumerc ◽

Muriel Golzio ◽

Volker Brinkmann ◽

...

Keyword(s):

Prostate Cancer ◽

Cancer Cells ◽

Sphingosine Kinase ◽

Immunosuppressive Drug ◽

Sphingosine Kinase 1 ◽

Prostate Cancer Cells