Differences in endoplasmic reticulum stress signalling kinetics determine cell survival outcome through activation of MKP-1

2011 ◽  
Vol 23 (1) ◽  
pp. 35-45 ◽  
Author(s):  
Bin Li ◽  
Ping Yi ◽  
Bi Zhang ◽  
Chanjuan Xu ◽  
Qiuyao Liu ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cell Survival ◽  
Survival Outcome ◽  
Stress Signalling

scholarly journals Monocyte Response to Different Campylobacter jejuni Lysates Involves Endoplasmic Reticulum Stress and the Lysosomal–Mitochondrial Axis: When Cell Death Is Better Than Cell Survival

Toxins ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 239 ◽  
Author(s):  
Barbara Canonico ◽  
Gianna Di Sario ◽  
Erica Cesarini ◽  
Raffaella Campana ◽  
Francesca Luchetti ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Endoplasmic Reticulum Stress ◽  
Cell Survival ◽  
Campylobacter Jejuni ◽  
Better Than

scholarly journals ATF4-Mediated Induction of 4E-BP1 Contributes to Pancreatic β Cell Survival under Endoplasmic Reticulum Stress

2008 ◽  
Vol 7 (3) ◽  
pp. 269-276 ◽  
Author(s):  
Suguru Yamaguchi ◽  
Hisamitsu Ishihara ◽  
Takahiro Yamada ◽  
Akira Tamura ◽  
Masahiro Usui ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cell Survival ◽  
Pancreatic Β Cell ◽  
Β Cell

scholarly journals Differential Effects of Endoplasmic Reticulum Stress-induced Autophagy on Cell Survival

2006 ◽  
Vol 282 (7) ◽  
pp. 4702-4710 ◽  
Author(s):  
Wen-Xing Ding ◽  
Hong-Min Ni ◽  
Wentao Gao ◽  
Yi-Feng Hou ◽  
Melissa A. Melan ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Endoplasmic Reticulum Stress ◽  
Cell Survival ◽  
Cancer Cells ◽  
Mammalian Cells ◽  
Cellular Response ◽  
Brefeldin A ◽  
Human Colon ◽  
The Impact

Autophagy is a cellular response to adverse environment and stress, but its significance in cell survival is not always clear. Here we show that autophagy could be induced in the mammalian cells by chemicals, such as A23187, tunicamycin, thapsigargin, and brefeldin A, that cause endoplasmic reticulum stress. Endoplasmic reticulum stress-induced autophagy is important for clearing polyubiquitinated protein aggregates and for reducing cellular vacuolization in HCT116 colon cancer cells and DU145 prostate cancer cells, thus mitigating endoplasmic reticulum stress and protecting against cell death. In contrast, autophagy induced by the same chemicals does not confer protection in a normal human colon cell line and in the non-transformed murine embryonic fibroblasts but rather contributes to cell death. Thus the impact of autophagy on cell survival during endoplasmic reticulum stress is likely contingent on the status of cells, which could be explored for tumor-specific therapy.

scholarly journals Messenger RNA targeting to endoplasmic reticulum stress signalling sites

Nature ◽  
2008 ◽  
Vol 457 (7230) ◽  
pp. 736-740 ◽  
Author(s):  
Tomás Aragón ◽  
Eelco van Anken ◽  
David Pincus ◽  
Iana M. Serafimova ◽  
Alexei V. Korennykh ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Messenger Rna ◽  
Rna Targeting ◽  
Stress Signalling
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