Bisphosphonates Are Associated With Reduced Risk of Colorectal Cancer: A Systematic Review and Meta-analysis

2013 ◽  
Vol 11 (3) ◽  
pp. 232-239.e1 ◽  
Author(s):  
Siddharth Singh ◽  
Abha Goyal Singh ◽  
Mohammad Hassan Murad ◽  
Paul J. Limburg
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Meta Analysis ◽  
Reduced Risk

scholarly journals PENGARUH KONSUMSI SERAT DENGAN PENGURANGAN RISIKO KANKER KOLON DI NEGARA BARAT: STUDI META ANALISIS

2018 ◽  
Vol 12 (2) ◽  
pp. 97
Author(s):  
Masrul Masrul
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Random Effect ◽  
Western Countries ◽  
Colorectal Cancer Patients ◽  
Published Research ◽  
Random Effect Models ◽  
Reduced Risk

The association between dietary fibre and colorectal cancer risk is controversial. This systematic review and meta-analysis was performed to determine fibre consumption reduced risk of colorectal cancer patients in western countries.The authors conducted a meta-analysis of published research articles on fibre consumption reduced risk of colorectal cancer patients in western countries published between January 2000 and January 2018 in the online article databases of PubMed, ProQuest and EBSCO. Pooled relative risk (PRR) were calculated with fixed and random-effect models. Data were processed using Stata version 14.2 (Stata Corporation). This study reviewed 405 articles. There are 7 studies conducted a systematic review and continued with Meta-analysis. The results showed fibre consumption reduced risk of colorectal cancer patients in western countries (RR = 0.83 [95% CI 0.75-0.93]). This analysis confirmed fibre consumption reduced risk of colorectal cancer patients in western countries.

scholarly journals Folate Intake,MTHFRPolymorphisms, and the Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis

2012 ◽  
Vol 2012 ◽  
pp. 1-24 ◽  
Author(s):  
Deborah A. Kennedy ◽  
Seth J. Stern ◽  
Ilan Matok ◽  
Myla E. Moretti ◽  
Moumita Sarkar ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Observational Studies ◽  
Methylenetetrahydrofolate Reductase ◽  
Meta Analysis ◽  
Risk Estimate ◽  
Folate Intake ◽  
Methylene Tetrahydrofolate Reductase ◽  
Methylene Tetrahydrofolate ◽  
Reduced Risk

Background. The objective was to determine whether relationships exist between the methylene-tetrahydrofolate reductase (MTHFR) polymorphisms and risk of colorectal cancer (CRC) and examine whether the risk is modified by level of folate intake.Methods. MEDLINE, Embase, and SCOPUS were searched to May 2012 using the terms “folic acid,” “folate,” “colorectal cancer,” “methylenetetrahydrofolate reductase,” “MTHFR.” Observational studies were included which (1) assessed the risk of CRC for each polymorphism and/or (2) had defined levels of folate intake for each polymorphism and assessed the risk of CRC.Results. From 910 references, 67 studies met our criteria; hand searching yielded 10 studies. The summary risk estimate comparing the677CT versus CC genotype was 1.02 (95% CI 0.95–1.10) and for677TT versus CC was 0.88 (95% CI 0.80–0.96) both with heterogeneity. The summary risk estimates for A1298C polymorphisms suggested no reduced risk. The summary risk estimate for high versus low total folate for the677CC genotype was 0.70 (95% CI 0.56–0.89) and the677TT genotype 0.63 (95% CI 0.41–0.97).Conclusion. These results suggest that the677TT genotype is associated with a reduced risk of developing CRC, under conditions of high total folate intake, and this associated risk remains reduced for bothMTHFR 677CC and TT genotypes.

scholarly journals Effects of β-Cryptoxanthin on Improvement in Osteoporosis Risk: A Systematic Review and Meta-Analysis of Observational Studies

Foods ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 296
Author(s):  
Sun Jo Kim ◽  
Nguyen Hoang Anh ◽  
Nguyen Co Diem ◽  
Seongoh Park ◽  
Young Hyun Cho ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hip Fracture ◽  
Bone Health ◽  
Observational Studies ◽  
Meta Analysis ◽  
Random Effects Model ◽  
High Intake ◽  
Quantitative Evidence ◽  
Osteoporosis Risk ◽  
Reduced Risk

Many studies have analyzed the effects of β-cryptoxanthin (BCX) on osteoporosis and bone health. This systematic review and meta-analysis aimed at providing quantitative evidence for the effects of BCX on osteoporosis. Publications were selected and retrieved from three databases and carefully screened to evaluate their eligibility. Data from the final 15 eligible studies were extracted and uniformly summarized. Among the 15 studies, seven including 100,496 individuals provided information for the meta-analysis. A random effects model was applied to integrate the odds ratio (OR) to compare the risk of osteoporosis and osteoporosis-related complications between the groups with high and low intake of BCX. A high intake of BCX was significantly correlated with a reduced risk of osteoporosis (OR = 0.79, 95% confidence interval (CI) 0.70–0.90, p = 0.0002). The results remained significant when patients were stratified into male and female subgroups as well as Western and Asian cohorts. A high intake of BCX was also negatively associated with the incidence of hip fracture (OR = 0.71, 95% CI 0.54–0.94, p = 0.02). The results indicate that BCX intake potentially reduces the risk of osteoporosis and hip fracture. Further longitudinal studies are needed to validate the causality of current findings.

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