Folate Intake,MTHFRPolymorphisms, and the Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis

Background. The objective was to determine whether relationships exist between the methylene-tetrahydrofolate reductase (MTHFR) polymorphisms and risk of colorectal cancer (CRC) and examine whether the risk is modified by level of folate intake.Methods. MEDLINE, Embase, and SCOPUS were searched to May 2012 using the terms “folic acid,” “folate,” “colorectal cancer,” “methylenetetrahydrofolate reductase,” “MTHFR.” Observational studies were included which (1) assessed the risk of CRC for each polymorphism and/or (2) had defined levels of folate intake for each polymorphism and assessed the risk of CRC.Results. From 910 references, 67 studies met our criteria; hand searching yielded 10 studies. The summary risk estimate comparing the677CT versus CC genotype was 1.02 (95% CI 0.95–1.10) and for677TT versus CC was 0.88 (95% CI 0.80–0.96) both with heterogeneity. The summary risk estimates for A1298C polymorphisms suggested no reduced risk. The summary risk estimate for high versus low total folate for the677CC genotype was 0.70 (95% CI 0.56–0.89) and the677TT genotype 0.63 (95% CI 0.41–0.97).Conclusion. These results suggest that the677TT genotype is associated with a reduced risk of developing CRC, under conditions of high total folate intake, and this associated risk remains reduced for bothMTHFR 677CC and TT genotypes.

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Dietary components and the risk of colorectal cancer: A systematic review and meta-analysis of observational studies

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2020.11.272 ◽

2021 ◽

Vol 47 (2) ◽

pp. e49

Author(s):

Pia Borgas ◽

Guadalupe Gonzalez ◽

Kirill Veselkov ◽

Reza Mirnezami

Keyword(s):

Colorectal Cancer ◽

Systematic Review ◽

Observational Studies ◽

Meta Analysis ◽

Dietary Components

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Effects of β-Cryptoxanthin on Improvement in Osteoporosis Risk: A Systematic Review and Meta-Analysis of Observational Studies

Foods ◽

10.3390/foods10020296 ◽

2021 ◽

Vol 10 (2) ◽

pp. 296

Author(s):

Sun Jo Kim ◽

Nguyen Hoang Anh ◽

Nguyen Co Diem ◽

Seongoh Park ◽

Young Hyun Cho ◽

...

Keyword(s):

Systematic Review ◽

Hip Fracture ◽

Bone Health ◽

Observational Studies ◽

Meta Analysis ◽

Random Effects Model ◽

High Intake ◽

Quantitative Evidence ◽

Osteoporosis Risk ◽

Reduced Risk

Many studies have analyzed the effects of β-cryptoxanthin (BCX) on osteoporosis and bone health. This systematic review and meta-analysis aimed at providing quantitative evidence for the effects of BCX on osteoporosis. Publications were selected and retrieved from three databases and carefully screened to evaluate their eligibility. Data from the final 15 eligible studies were extracted and uniformly summarized. Among the 15 studies, seven including 100,496 individuals provided information for the meta-analysis. A random effects model was applied to integrate the odds ratio (OR) to compare the risk of osteoporosis and osteoporosis-related complications between the groups with high and low intake of BCX. A high intake of BCX was significantly correlated with a reduced risk of osteoporosis (OR = 0.79, 95% confidence interval (CI) 0.70–0.90, p = 0.0002). The results remained significant when patients were stratified into male and female subgroups as well as Western and Asian cohorts. A high intake of BCX was also negatively associated with the incidence of hip fracture (OR = 0.71, 95% CI 0.54–0.94, p = 0.02). The results indicate that BCX intake potentially reduces the risk of osteoporosis and hip fracture. Further longitudinal studies are needed to validate the causality of current findings.

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PWE-153 Association Between Constipation and Colorectal Cancer: Systematic Review and Meta-Analysis of Observational Studies

Gut ◽

10.1136/gutjnl-2013-304907.441 ◽

2013 ◽

Vol 62 (Suppl 1) ◽

pp. A193.2-A193

Author(s):

A M Power ◽

N J Talley ◽

A C Ford

Keyword(s):

Colorectal Cancer ◽

Systematic Review ◽

Observational Studies ◽

Meta Analysis

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Letter to the editor: Correction “Nitrate-nitrite exposure through drinking water and diet and risk of colorectal cancer: A systematic review and meta-analysis of observational studies”

Clinical Nutrition ◽

10.1016/j.clnu.2021.09.027 ◽

2021 ◽

Vol 40 (11) ◽

pp. 5443-5444

Author(s):

Tim Chambers ◽

Simon Hales ◽

Andrew Anglemyer

Keyword(s):

Colorectal Cancer ◽

Systematic Review ◽

Drinking Water ◽

Observational Studies ◽

Meta Analysis ◽

Letter To The Editor

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Methylene tetrahydrofolate reductase (MTHFR) gene rs1801133 C>T polymorphisms and response to 5-FU based chemotherapy in patients with colorectal cancer: a meta-analysis

Pteridines ◽

10.1515/pteridines-2019-0015 ◽

2019 ◽

Vol 30 (1) ◽

pp. 126-132

Author(s):

Huafeng Jiang ◽

Yi Shen

Keyword(s):

Colorectal Cancer ◽

Statistical Difference ◽

Genetic Model ◽

Meta Analysis ◽

Recessive Model ◽

Funnel Plot ◽

Methylene Tetrahydrofolate Reductase ◽

Dominant Genetic Model ◽

Regression Test ◽

Methylene Tetrahydrofolate

Abstract Background: Methylene tetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. Single nucleotide polymorphisms (SNP) of MTHF rs1801133 C>T can influence susceptibility to colorectal cancer. However, an association between MTHFR rs1801133 C>T polymorphisms and response to 5-Fluorouracil (5-FU) based chemotherapy in patients with colorectal cancer was not clear. Methods: Studies relevant to MTHFR rs1801133 C>T polymorphisms and response to 5-FU based chemotherapy in patients with colorectal cancer were systematic searched in the electronic databases of PubMed, Web of Science, Embase, and China National Knowledge Infrastructure (CNKI). The genotypes of CC, CT, and TT were extracted from each included publication. The genotypes CC, CT, and TT distribution in 5-FU based chemotherapy response and resistance groups were calculated and pooled through random or fixed effect model by the effect size of odds ratio (OR) and 95% confidence interval (95% CI). The publication bias was evaluated through Begg’s funnel plot and Egger’s line regression test. Results: After searching the electronic databases, 16 studies related to MTHFR gene rs1801133 C>T polymorphisms and a response to 5-FU based chemotherapy in patients with colorectal cancer were included in the present meta-analysis. The pooled data showed no statistical difference in tumor response rate between CT+TT and CC groups in the dominant genetic model CT+CC vs CC (OR=1.21, 95% CI: 0.93~1.59, p>0.05) and recessive model TT vs CT+CC (OR=1.37, 95% CI: 0.91~2.06, p>0.05). The grade 3-4 adverse reaction rate between CT+TT and CC groups also had no statistical difference in the dominant genetic model CT+CC vs CC (OR=0.90, 95% CI: 0.76~1.07, p>0.05) and recessive model TT vs CT+CC (OR=1.12, 95% CI: 0.84~1.50, p>0.05). The Begg’s funnel plot and Egger’s line regression test demonstrated no publication bias. Conclusion: The response and adverse reaction of 5-FU based chemotherapy in colorectal patients were not different in terms of MTHFR rs1801133 C>T polymorphisms.

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