Rate, Risk Factors, and Outcomes of Nonadherence in Pediatric Patients With Celiac Disease: A Systematic Review

2020 ◽  
Vol 18 (3) ◽  
pp. 562-573 ◽  
Author(s):  
Anna Myléus ◽  
Norelle R. Reilly ◽  
Peter H.R. Green
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Celiac Disease ◽  
Pediatric Patients ◽  
Rate Risk

Risk factors for the development of hypocalcemia in pediatric patients after total thyroidectomy – A systematic review

2021 ◽  
Vol 143 ◽  
pp. 110666
Author(s):  
Kung-Ting Kao ◽  
Elspeth C. Ferguson ◽  
Geoff Blair ◽  
Neil K. Chadha ◽  
Jean-Pierre Chanoine
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Total Thyroidectomy ◽  
Pediatric Patients

Does Having Rotavirus Infection in Early Childhood Increase the Risk of Celiac Disease?

2021 ◽  
Author(s):  
Meryem Keceli Basaran ◽  
Caner Dogan ◽  
Mahmut Bal ◽  
Seda Geylani Gulec ◽  
Nafiye Urganci
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Celiac Disease ◽  
Genetic Factors ◽  
Pediatric Patients ◽  
Control Group ◽  
Rotavirus Infection ◽  
Rotavirus Gastroenteritis ◽  
Significant Difference ◽  
Espghan Guidelines

Abstract Objective With the increasing prevalence of celiac disease (CD) in the population, possible risk factors are under investigation. Environmental and genetic factors that trigger the immune response have been analyzed for many years. This study investigates the presence of CD in children with rotavirus infection. Rotavirus infection is thought to be a risk factor for CD. Methods Included in the study were 105 of 160 pediatric patients hospitalized due to symptomatic rotavirus infection between 2012 and 2018. These children were screened for CD 45.6 ± 18.2 (14–90) months following the rotavirus infection diagnosed with CD as per ESPGHAN guidelines. Results A total of 105 pediatric patients who had rotavirus gastroenteritis were included in the study. The age of the children with rotavirus infection was 3.98 ± 1 (2–6) months. In terms of CD, it was 45.6 ± 18.2 months. Around 14 to 90 months later, patients were called for control. CD developed in four (3.8%) of the children with rotavirus, whereas none of the children in the control group developed CD. Conclusion Rotavirus infection may be a risk factor for CD through immune mechanisms. There are genetic and various environmental factors for the development of CD. Although the CD's occurrence on children who had rotavirus gastroenteritis in our study also supported this situation, there was no statistically significant difference.

Allergic rhinitis and asthma assessment of risk factors in pediatric patients: A systematic review

2020 ◽  
Vol 129 ◽  
pp. 109759 ◽  
Author(s):  
Domenico Testa ◽  
Matteo DI Bari ◽  
Michele Nunziata ◽  
Generoso DE. Cristofaro ◽  
Giuseppe Massaro ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Allergic Rhinitis ◽  
Pediatric Patients

Risk factors for postoperative cerebellar mutism syndrome in pediatric patients: a systematic review and meta-analysis

2021 ◽  
pp. 1-9
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Pediatric Patients ◽  
Intraoperative Imaging ◽  
Meta Analysis ◽  
Univariate Analysis ◽  
Significant Risk ◽  
Cerebellar Hemisphere ◽  
Superior Cerebellar Peduncle ◽  
Cerebellar Mutism

OBJECTIVE A review article assessing all the risk factors reported in the literature for postoperative cerebellar mutism syndrome (pCMS) among children remains absent. The authors sought to perform a systematic review and meta-analysis to evaluate this issue. METHODS PubMed, Embase, and Web of Science were queried to systematically extract potential references. The articles relating to pCMS were required to be written in the English language, involve pediatric patients (≤ 18 years of age), and provide extractable data, which included a comparison group of patients who did not develop pCMS. The quality of the included studies was evaluated using the Newcastle-Ottawa Scale. Data were pooled using RevMan 5.4, and publication bias was assessed by visual inspection for funnel plot asymmetry. The study protocol was registered through PROSPERO (ID: CRD42021256177). RESULTS Overall, 28 studies involving 2276 patients were included. Statistically significant risk factors identified from univariate analysis were brainstem invasion (OR 4.28, 95% CI 2.23–8.23; p < 0.0001), fourth ventricle invasion (OR 12.84, 95% CI 4.29–38.44; p < 0.00001), superior cerebellar peduncle invasion (OR 6.77, 95% CI 2.35–19.48; p = 0.0004), diagnosis of medulloblastoma (OR 3.26, 95% CI 1.93–5.52; p < 0.0001), medulloblastoma > 50 mm (OR 8.85, 95% CI 1.30–60.16; p = 0.03), left-handedness (OR 6.57, 95% CI 1.25–34.44; p = 0.03), and a vermis incision (OR 5.44, 95% CI 2.09–14.16; p = 0.0005). On the other hand, a tumor located in the cerebellar hemisphere (OR 0.23, 95% CI 0.06–0.92; p = 0.04), cerebellar hemisphere compression (OR 0.23, 95% CI 0.11–0.45; p < 0.0001), and intraoperative imaging (OR 0.36, 95% CI 0.18–0.72; p = 0.004) reduced the risk of pCMS. CONCLUSIONS This study provides the largest and most reliable review of risk factors associated with pCMS. Although some risk factors may be dependent on one another, the data may be used by surgeons to better identify patients at risk for pCMS and for intervention planning.

scholarly journals Efficacy of duodenal bulb biopsy for diagnosis of celiac disease: a systematic review and meta-analysis

2018 ◽  
Vol 06 (11) ◽  
pp. E1369-E1378 ◽  
Author(s):  
Thomas R. McCarty ◽  
Corey R. O’Brien ◽  
Anas Gremida ◽  
Christina Ling ◽  
Tarun Rustagi
Keyword(s):  
Systematic Review ◽  
Celiac Disease ◽  
Pediatric Patients ◽  
Web Of Science ◽  
Diagnostic Yield ◽  
Meta Analysis ◽  
Duodenal Bulb ◽  
Cochrane Library ◽  
Data Abstraction ◽  
Pediatric Populations

Abstract Background and study aims Although duodenal biopsy is considered the “gold standard” for diagnosis of celiac disease, the optimal location of biopsy within the small bowel for diagnosis remains unclear. The primary aim of this study was to perform a structured systematic review and meta-analysis to evaluate the diagnostic utility of endoscopic duodenal bulb biopsy for celiac disease. Patients and methods Searches of PubMed, EMBASE, Web of Science, and Cochrane Library databases were performed from 2000 through December 2017. Review of titles/abstracts, full review of potentially relevant studies, and data abstraction was performed. Measured outcomes of adult and pediatric patients included location of biopsy, mean number of biopsies performed, and diagnosis of celiac disease as defined by the modified Marsh-Oberhuber classification. Results A total of 17 studies (n = 4050) were included. Seven studies evaluated adults and 11 studies assessed pediatric populations. Mean age of adults and pediatric patients was 46.70 ± 2.69 and 6.33 ± 1.26 years, respectively. Overall, sampling from the duodenal bulb demonstrated a 5 % (95 % CI 3 – 9; P < 0.001) increase in the diagnostic yield of celiac disease. When stratified by pediatric and adult populations, duodenal bulb biopsy demonstrated a 4 % (95 % CI: 1 to 9; P < 0.001) and 8 % (95 % CI: 6 to 10; P < 0.001) increase in the diagnostic yield of celiac disease. Non-celiac histologic diagnoses including Brunner gland hyperplasia and peptic duodenitis were reported more commonly in the duodenal bulb as compared to the distal duodenum with an increase in diagnostic yield of 4 % (95 % CI 3 – 5; P < 0.001) and 1 % (95 % CI 1 – 2; P < 0.001), respectively. Conclusions Based upon our results, biopsy and histologic examination of duodenal bulb during routine upper endoscopy increases the diagnostic yield of celiac disease.

scholarly journals Prevalence of celiac disease and celiac-related antibody status in pediatric patients with type 1 diabetes in Jordan

2019 ◽  
Vol 8 (6) ◽  
pp. 780-787 ◽  
Author(s):  
Rasha Odeh ◽  
Abeer Alassaf ◽  
Lubna Gharaibeh ◽  
Sarah Ibrahim ◽  
Fareed Khdair Ahmad ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Pediatric Patients ◽  
Arab World ◽  
Duodenal Biopsy ◽  
Positive Serology

Objective Scientific findings regarding the prevalence of celiac disease (CD) in pediatric patients with type 1 diabetes (T1D) in the Arab world are scarce. We aimed to determine the prevalence of biopsy-proven celiac disease (BPCD) among pediatric patients with T1D from Jordan. We also assessed the possible predictors for developing CD in this cohort of patients and we compared T1D patients who developed BPCD with those who had positive CD serology but negative histology and/or fluctuating CD serology. Methods Celiac serology and duodenal biopsy results from 2012 to 2017 were collected from patients with T1D. The outcome of positive celiac serology and the risk factors for CD in T1D patients were investigated. Results A total of 538 children of which 278 boys (51.7%) were included in the study. The prevalence of positive serology and the diagnosis of BPCD in this cohort of T1D patients were 16.6 and 9.1% respectively. Eighty percent of those with BPCD were asymptomatic and 47% were diagnosed with CD at onset of T1D. Spontaneous normalization of celiac serology occurred in 23.6% of those with positive serology. Conclusion CD is prevalent in T1D pediatric patients from Jordan (9.1%). It is often asymptomatic and the majority of cases were diagnosed at onset or within 5 years of T1D diagnosis. Spontaneous normalization of CD serology occurred in some patients with T1D. Hence, a watchful follow-up is recommended in such patients.

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