Safety and Tolerability of Rupatadine Administered to Asthmatic Patients With Persistent Allergic Rhinitis

Eosinophils are important to the pathogenesis of allergic asthma, and are increased in bronchoalveolar lavage within four hours after bronchoprovocation of allergic asthmatic patients, and remain significantly increased up to 24 hours later. While the components of human eosinophil granules have been recently isolated and purified, the mechanisms of degranulation have yet to be elucidated.We obtained blood from two volunteers who had a history of allergic rhinitis and asthma and a positive skin test (5x5mm wheal) to Alternaria and Ragweed. Eosinophils were obtained using a modification of the method described by Roberts and Gallin.

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Topical nasal steroids for intermittent and persistent allergic rhinitis in children

10.1002/14651858.cd003163.pub3 ◽

2005 ◽

Author(s):

JJ Al Sayyad ◽

D Alhashimi ◽

Z Fedorowicz ◽

A Jamal

Keyword(s):

Allergic Rhinitis ◽

Persistent Allergic Rhinitis ◽

Nasal Steroids

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Effect of adjunctive sodium hyaluronate versus surfactant nasal irrigation on mucociliary clearance in allergic rhinitis: a single-blind, randomised, controlled study

The Journal of Laryngology & Otology ◽

10.1017/s0022215121000967 ◽

2021 ◽

pp. 1-4

Author(s):

E Ocak ◽

S Mulazimoglu ◽

D Kocaoz ◽

E Mirici ◽

E Dagli ◽

...

Keyword(s):

Allergic Rhinitis ◽

Mucociliary Clearance ◽

Isotonic Saline ◽

Sodium Hyaluronate ◽

Controlled Study ◽

Control Group ◽

Clearance Time ◽

Nasal Irrigation ◽

Persistent Allergic Rhinitis ◽

Randomised Controlled

Abstract Objective To investigate the effects of nasal irrigation with sodium hyaluronate and surfactant solutions on mucociliary clearance time in patients with mild persistent allergic rhinitis. Methods A total of 120 patients diagnosed with mild persistent allergic rhinitis were enrolled in this prospective study. The patients were allocated randomly to the surfactant, sodium hyaluronate or isotonic saline (as a control) nasal irrigation group. The mucociliary clearance times and improvements in mucociliary clearance times were compared. Results Improvements in mean mucociliary clearance time were significantly greater in the surfactant and sodium hyaluronate groups than in the control group (p < 0.01). The mean post-treatment mucociliary clearance time of the surfactant group was significantly lower than that of the control (p < 0.001) and sodium hyaluronate groups (p = 0.03). Conclusion Surfactant and sodium hyaluronate nasal irrigation solutions may both be used as adjunctive treatments for allergic rhinitis. Surfactant nasal irrigation resulted in better mucociliary clearance times.

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Correlation of Nasal Fluid Biomarkers and Symptoms in Patients with Persistent Allergic Rhinitis

Annals of Otology Rhinology & Laryngology ◽

10.1177/0003489419898717 ◽

2020 ◽

Vol 129 (6) ◽

pp. 542-547

Author(s):

Su Il Kim ◽

Oh Eun Kwon ◽

Jung Min Park ◽

Jeon Gang Doo ◽

Seok Hyun Kim ◽

...

Keyword(s):

Allergic Rhinitis ◽

Inverse Correlation ◽

Lavage Fluid ◽

Nasal Symptom ◽

Clara Cell ◽

Cell Protein ◽

Enzyme Linked Immunosorbent Assay ◽

Prick Test ◽

Persistent Allergic Rhinitis ◽

Nasal Fluid

Objectives: This study investigated whether the biomarkers present in nasal fluid reflect the severity of symptoms in patients with persistent allergic rhinitis (PAR). Methods: We enrolled 29 PAR patients complaining of nasal symptoms and testing positive to skin prick test. Patients’ total nasal symptom score (TNSS) was measured and their nasal lavage fluid (NALF) was collected. The levels of biomarkers including Clara cell protein 16 (CC16), tryptase, and interleukin 5 (IL-5) in NALF were determined via enzyme-linked immunosorbent assay (ELISA). Results: PAR patients were classified into persistent mild and persistent moderate-to-severe groups according to the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. The CC16 alone was significantly negatively correlated with TNSS ( P < .05). Further, the CC16 level was significantly lower in persistent moderate-to-severe group than persistent mild group of patients ( P < .05). Conclusions: The levels of CC16 alone among several NALF biomarkers showed an inverse correlation with symptoms of PAR patients.

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