scholarly journals A 67-Year-Old Male Patient With COVID-19 With Worsening Respiratory Function and Acute Kidney Failure

CHEST Journal ◽  
2022 ◽  
Vol 161 (1) ◽  
pp. e5-e11
Author(s):  
Max Melchers ◽  
Barbara Festen ◽  
Bianca M. den Dekker ◽  
Eline R.M. Mooren ◽  
Annelien L. van Binsbergen ◽  
...  
2019 ◽  
pp. 47-58
Author(s):  
Lina Lozano Lesmes ◽  
Natalia Andrea Quintero Guzmán ◽  
Jenny Lizeth Cuellar Devia ◽  
Edwin Alberto Torres García ◽  
Samuel Arias Valencia

Objetivo: Cuantificar la incidencia y los factores de exposición relacionados con el desarrollo de la insuficiencia renal aguda en pacientes hospitalizados en unidades de cuidados intensivos adulto durante tres meses. Materiales y métodos: se  realizó un estudio epidemiológico de tipo cuantitativo con dos componentes: descriptivo longitudinal y de cohorte histórica, se emplearon los criterios de AKIN, participaron dos instituciones de salud, una de orden privado y otra de orden público.  Resultados: Se incluyeron 186 pacientes, con una edad promedio de  56,2 +/- 20,14 años.  Se encontró una incidencia del 21,6 % (IC 95 % 17-30) de insuficiencia renal aguda y una tasa de incidencia de 29,2 por cada 100 pacientes año exposición. En promedio la elevación de creatinina fue 0,47 mg/dL y el gasto urinario de 0,37 cc/kg/h, los días en ocurrir el evento 3,1 (IC 95 % 2,48-3,74). Se encontró relación estadísticamente significativa entre insuficiencia cardíaca aguda 6,84 días (IC 95 % 4,21-9,48) (p=0,026),   posoperatorios 9,82 días (IC 95 % 8,42-11,2) (p=0,04) y trauma craneoencefálico 4,5 días (IC 95 % 1,56-7,44) (p=0,043) como causas de ingreso y la aparición de insuficiencia renal aguda Conclusiones:  La proporción de incidencia de insuficiencia renal aguda identificada en el presente estudio, es similar a estudios realizados en Colombia, sin embargo, difiere de otros realizados en el exterior. La sepsis fue el diagnóstico con mayor frecuencia entre los pacientes con insuficiencia renal aguda, seguido de la insuficiencia cardíaca aguda. Se encontró significancia estadística en el desarrollo de la insuficiencia renal aguda y la administración de nitroglicerina. Palabras clave: Enfermedad renal, Estudios Epidemiológicos, Cuidados Críticos, Adulto.    Acute kidney failure in critically ill adults from two health care institutions. Abstract Objective: To quantify the incidence and factors of exposure related to the development of acute kidney failure in hospitalized patients in the adult intensive care unit during three months. Materials and methods: An epidemiological study of quantitative type with two components was performed: descriptive longitudinal study and a retrospective cohort study, AKIN criteria were used, two health care institutions (one private and one public) participated. Results: 186 patients were included with an average age of 56.2 +/- 20,14 years. An incidence of 21.6% was found (IC 95 % 17-30) of acute kidney failure and a rate of incidence of 29.2 for every 100 patients / year of exposure. On average the creatinine elevation was of 0.47 mg/dL and the urine output was of 0.37 cc/kg/h, days of event occurrence 3.1 (IC 95 % 2.48-3.74). A significant statistical relationship was found between acute heart failure 6.84 days (IC 95% 4.21-9.48) (p=0.026), post-operatives 9.82 days (IC 95 % 8.42-11.2) (p=0.04) and traumatic brain injury 4.5 days (IC 95 % 1.56-7.44) (p=0.043), as causes of admission and appearance of acute kidney failure. Conclusions:  The incidence proportion of acute kidney failure identified in the present study, is similar to other studies performed in Colombia, however, it differs from studies performed in other countries. Sepsis was the most frequent diagnosis among patients with acute kidney failure, followed by acute heart failure. Statistical significance was found in the development of acute kidney failure and the intake of nitroglycerin. Keywords: Kidney failure, Epidemiological studies, Critical care, Adult.    Insuficiência renal aguda em adultos criticamente doentes em duas instituições hospitalares   Resumo Objetivo: Quantificar a incidência e os fatores de exposição relacionados com o desenvolvimento da Insuficiência Renal Aguda (IRA) em pacientes adultos hospitalizados em unidades de terapia intensiva durante três meses. Materiais e métodos: realizou-se um estudo epidemiológico de tipo quantitativo com dois componentes: descritivo longitudinal e de coorte histórica, empregaram-se os critérios de AKIN (Acute Kidney Injury Network), participaram duas instituições de saúde, uma de ordem privado e outra de ordem pública.  Resultados: Incluíram-se 186 pacientes, com uma idade média de 56,2 ± 20,14 anos. Encontrou-se uma incidência do 21,6 % (IC 95 % 17-30) de insuficiência renal aguda e uma taxa de incidência de 29,2 por cada 100 pacientes ano exposição. Em média a elevação de creatinina foi de 0,47 mg/dL e o gasto urinário de 0,37 cc/kg/h, os dias em ocorrer o evento 3,1 (IC 95 % 2,48-3,74). Encontrou-se relação estatisticamente significativa entre insuficiência cardíaca aguda (ICA) 6,84 dias (IC 95 % 4,21-9,48) (p=0,026),   pós-operatórios 9,82 dias (IC 95 % 8,42-11,2) (p=0,04) e traumatismo cranioencefálico (TCE) 4,5 dias (IC 95 % 1,56-7,44) (p=0,043) como causas de ingresso e a aparição de insuficiência renal aguda Conclusões:  A proporção de incidência de insuficiência renal aguda identificada no presente estudo, é similar a estudos realizados na Colômbia, no entanto, difere de outros realizados no exterior. A sepse foi o diagnóstico com maior frequência entre os pacientes com insuficiência renal aguda, seguido da insuficiência cardíaca aguda. Obteve-se significância estadística no desenvolvimento da insuficiência renal aguda e a administração de nitroglicerina. Palavras-chave: Adulto, Cuidados Críticos, Doença renal, Estudos Epidemiológicos. 


2014 ◽  
Vol 2 (2) ◽  
pp. 313-315
Author(s):  
Alfred Ibrahimi ◽  
Saimir Kuci ◽  
Ervin Bejko ◽  
Stavri Llazo ◽  
Esmerilda Bulku ◽  
...  

Rhabdomyolysis and myoglobinuria are the main cause of the acute renal failure. Hyperkalemia is life threating complication of rhabdomyolisis due to massive cell destruction. We report a case of very severe hyperkalemia treated successfully with high volume hemodiafiltration (CVVHDF).


Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Haidar Moustafa ◽  
Daniela Schoene ◽  
Lars-Peder Pallesen ◽  
Alexandra Prakapenia ◽  
Timo Siepmann ◽  
...  

Introduction: To explore kidney safety profile of osmotic diuretic mannitol in patients with malignant middle cerebral artery (MCA) infarction. Methods: We analyzed data from consecutive patients with malignant MCA infarction (01/2008-12/2017). Malignant MCA infarction was defined according to clinical and radiographic DESTINY criteria. Clinical and laboratory variables were collected for all patients. We compared clinical endpoints including acute kidney failure (AKF; according to Kidney Disease: Improving Global Outcomes [KDIGO] definition) and hemodialysis between patients who received mannitol and those who did not. Multivariable model was built to explore predictor variables of AKF, in-hospital death and functional outcome at discharge. Results: Overall, 228 patients with malignant MCA infarction were analyzed: median age 67 years (IQR, 56-76), 58% men, median NIHSS 23 (17-32) points. Decompressive craniectomy was performed in 103/228 (45.2%) patients. Mannitol was administered in 100/228 (43.9%) patients over an average of 85 (30.3-139.3) hours. Average dosage was 700 (250-1050) g. Patients treated with mannitol more frequently suffered from AKF (40% vs. 7.9%; p<0.0001) and needed hemodialysis (7.4% vs. 0.9%; p=0.024) than patients without mannitol. At discharge, kidney function completely recovered in 38.5% and 20%, respectively (p=0.459). In multivariable model adjusted for age, history of chronic kidney disease, nephrotoxic premedication, admission systolic blood pressure, concurrent urinary tract infection, contrast agent exposure and peak osmolality, mannitol therapy emerged as single predictor of AKF (OR 4.14, 95%CI 1.2-14.2; p=0.024). Neither AKF nor mannitol therapy was associated with in-hospital death or short-term functional outcome (p>0.05). Conclusions: Acute kidney failure appears to be a frequent complication of osmotic diuretic mannitol in patients with malignant MCA infarction. Given the lack of evidence supporting effectiveness of mannitol in these patients, its use should be carefully considered.


2009 ◽  
pp. 1619-1628 ◽  
Author(s):  
Michael Zappitelli ◽  
Stuart L. Goldstein

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