Examining the link between emotional childhood abuse and social relationships in midlife: The moderating role of the oxytocin receptor gene

Sexual communication is a pivotal part of interpersonal relationships; recent research reveals associations between sexual communication and various relational outcomes. Within the broad domain of sexual communication, current scholarship specifically addresses the role of postsex communication in relationships and its links to physiological and genetic markers. Given these advancements, the present chapter offers an overview of research linking physiology, hormones, and genes to communication after sexual activity. The chapter first presents reviews of two key hormones in sexual communication research: testosterone (T) and oxytocin (O). The oxytocin receptor gene and its link to social behavior broadly, and sexual behavior specifically, is also explored. The chapter then offers a review of several theories relevant to understanding the hormonal underpinnings of sexual communication, as well as future directions for research exploring sexual communication and physiology.

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A Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment

Journal of the American Academy of Child & Adolescent Psychiatry ◽

10.1016/j.jaac.2019.03.006 ◽

2019 ◽

Vol 58 (12) ◽

pp. 1207-1216 ◽

Cited By ~ 2

Author(s):

Philipp Toepfer ◽

Kieran J. O'Donnell ◽

Sonja Entringer ◽

Christine M. Heim ◽

David T.S. Lin ◽

...

Keyword(s):

Quantitative Trait Locus ◽

Intergenerational Transmission ◽

Childhood Maltreatment ◽

Quantitative Trait ◽

Receptor Gene ◽

Tissue Expression ◽

Oxytocin Receptor ◽

Oxytocin Receptor Gene ◽

Trait Locus

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Common Oxytocin Receptor Gene Polymorphisms and the Risk for Preterm Birth

Disease Markers ◽

10.1155/2013/798914 ◽

2013 ◽

Vol 34 (1) ◽

pp. 51-56 ◽

Cited By ~ 7

Author(s):

Lorenz Kuessel ◽

Christoph Grimm ◽

Martin Knöfler ◽

Peter Haslinger ◽

Heinz Leipold ◽

...

Keyword(s):

Preterm Birth ◽

Gene Polymorphisms ◽

Haplotype Analysis ◽

Receptor Gene ◽

Oxytocin Receptor ◽

Oxytocin Receptor Gene ◽

Haplotype Combination ◽

Increased Risk ◽

Receptor Gene Polymorphisms

Oxytocin is crucially involved in the onset and maintenance of labor. We investigated the association between oxytocin receptor gene polymorphisms and preterm birth. The presence of four common oxytocin receptor gene polymorphisms (rs2254298, rs53576, rs2228485 and rs237911) was evaluated in one hundred women with preterm birth and one hundred healthy women using restriction fragment length polymorphism genotyping. No association was found between the presence of any individual oxytocin receptor gene polymorphism and preterm birth. In haplotype analysis, the haplotype combination of rs2254298 A allele, rs2228485 C allele and rs237911 G allele was found to be significantly associated with an increased risk of preterm birth (OR = 3.2 [CI 1.04–9.8],p= 0.043). In conclusion our findings suggest that a combination of three oxytocin receptor gene polymorphisms is associated with an increased risk for preterm birth. We propose further studies investigating the role of oxytocin receptor gene polymorphisms and preterm birth.

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