This handbook offered a review of cutting-edge research in the field of interpersonal communication and posed future directions to extend the literature focused on the bidirectional associations between communication and the human body. This chapter serves to summarize the handbook chapters by first reviewing biomarkers favored in communication scholarship, specifically cortisol, skin conductivity, heart rate, blood pressure, and neural activity. Next, several emerging areas of investigation are noted, namely the consideration of testosterone, oxytocin, dehydroepiandrosterone sulfate, immune response indicators, and plasma glucose levels. The conclusion specifies directions for future research and advocates for interdisciplinary collaborations with physiologists, neuroendocrinologists, neurologists, and other researchers studying life sciences.